International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 2 , Pages 403-409 , 1 February 2010

Dosimetric Factors Associated With Long-Term Dysphagia After Definitive Radiotherapy for Squamous Cell Carcinoma of the Head and Neck

Presented in part at the American Society for Therapeutic Radiology and Oncology meeting, September 21–25, 2008, Boston, MA.

  • Jimmy J. Caudell, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Philip E. Schaner, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Renee A. Desmond, D.V.M, Ph.D.

      Affiliations

    • Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Ruby F. Meredith, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Sharon A. Spencer, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • James A. Bonner, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL
    • Corresponding Author InformationReprint requests to: James A. Bonner, M.D., Department of Radiation Oncology, University of Alabama at Birmingham, 619 19th St S, WTI 105, Birmingham, AL 35249. Tel: (205) 934-2761; Fax: (205) 975-5186

Received 13 November 2008 ,Revised 27 January 2009 ,Accepted 9 February 2009.

References 

  1. Terrell JE, Ronis DL, Fowler KE, et al. Clinical predictors of quality of life in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004;130:401–408
  2. Rosenthal DI, Lewin JS, Eisbruch A. Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol. 2006;24:2636–2643
  3. Caudell JJ, Schaner PE, Meredith RF, et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;73:410–415
  4. Duan J, Shen S, Spencer SA, et al. A dynamic supraclavicular field-matching technique for head-and-neck cancer patients treated with IMRT. Int J Radiat Oncol Biol Phys. 2004;60:959–972
  5. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567–578
  6. Curran D, Giralt J, Harari PM, et al. Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. J Clin Oncol. 2007;25:2191–2197
  7. Eisbruch A, Schwartz M, Rasch C, et al. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?. Int J Radiat Oncol Biol Phys. 2004;60:1425–1439
  8. Pauloski BR, Rademaker AW, Logemann JA, et al. Swallow function and perception of dysphagia in patients with head and neck cancer. Head Neck. 2002;24:555–565
  9. Caglar HB, Tishler RB, Othus M, et al. Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:1110–1118
  10. Feng FY, Kim HM, Lyden TH, et al. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: Early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2007;68:1289–1298
  11. Jensen K, Lambertsen K, Grau C. Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: Frequency, intensity and correlation with dose and volume parameters. Radiother Oncol. 2007;85:74–82
  12. Levendag PC, Teguh DN, Voet P, et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship. Radiother Oncol. 2007;85:64–73
  13. Lee JH, Machtay M, Unger LD, et al. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124:871–875
  14. Ang KK, Harris J, Garden AS, et al. Concomitant boost radiation plus concurrent cisplatin for advanced head and neck carcinomas: Radiation therapy oncology group phase II trial 99-14. J Clin Oncol. 2005;23:3008–3015
  15. Staar S, Rudat V, Stuetzer H, et al. Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy—Results of a multicentric randomized German trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;50:1161–1171
  16. Amdur RJ, Li JG, Liu C, Hinerman RW, Mendenhall WM. Unnecessary laryngeal irradiation in the IMRT era. Head Neck. 2004;26:257–263discussion 263–264
  17. Dabaja B, Salehpour MR, Rosen I, et al. Intensity-modulated radiation therapy (IMRT) of cancers of the head and neck: Comparison of split-field and whole-field techniques. Int J Radiat Oncol Biol Phys. 2005;63:1000–1005
  18. Webster GJ, Rowbottom CG, Ho KF, Slevin NJ, Mackay RI. Evaluation of larynx-sparing techniques with IMRT when treating the head and neck. Int J Radiat Oncol Biol Phys. 2008;72:617–622
  19. Teguh DN, Levendag PC, Noever I, et al. Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys. 2008;72:1119–1127
  20. Lee N, Mechalakos J, Puri DR, Hunt M. Choosing an intensity-modulated radiation therapy technique in the treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2007;68:1299–1309

 Conflict of interest: James A. Bonner, M.D. receives occasional honoraria from Bristol-Myers Squibb Co. and ImClone Systems Inc.

PII: S0360-3016(09)00245-4

doi: 10.1016/j.ijrobp.2009.02.017

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 2 , Pages 403-409 , 1 February 2010

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