« Previous Next » International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3 , Pages 747-754 , 1 March 2010

Dose–Volume Constraints to Reduce Rectal Side Effects From Prostate Radiotherapy: Evidence From MRC RT01 Trial ISRCTN 47772397

Sarah L. Gulliford, Ph.D.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
- Reprint requests to: Sarah L. Gulliford, Ph.D., Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Cotswold Rd., Sutton SM2 5NG United Kingdom. Tel: (+44) 208-661-3675; Fax: (+44) 208-643-3812
Kerwyn Foo, F.R.A.N.Z.C.R.
- Department of Radiation Oncology, Illawarra Cancer Care Centre, Wollongong Hospital, NSW, Australia
Rachel C. Morgan, M.Sc.
- Cancer Group, Medical Research Council Clinical Trials Unit, London, United Kingdom
Edwin G. Aird, Ph.D.
- Department of Medical Physics, Mount Vernon Hospital, Northwood, United Kingdom
A. Margaret Bidmead, M.Sc.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
Helen Critchley, Ph.D.
- Atomic Weapons Establishment, Aldermaston, United Kingdom
Philip M. Evans, D.Phil.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
Stefano Gianolini, Ph.D.
- Tomotherapy Inc., Culliganlaan, Diegem, Belgium
W. Philip Mayles, Ph.D.
- Department of Physics, Clatterbridge Centre for Oncology, Wirral, United Kingdom
A. Rollo Moore, M.Sc.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
Beatriz Sánchez-Nieto, Ph.D.
- Servicio de Radioterapia, Clinica Alemana de Santiago, Santiago, Chile
Mike Partridge, Ph.D.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
Matthew R. Sydes, C.Stat
- Cancer Group, Medical Research Council Clinical Trials Unit, London, United Kingdom
Steve Webb, D.Sc.
- Joint Department of Physics, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
David P. Dearnaley, F.R.C.R.
- Department of Academic Urology, Institute of Cancer Research and Royal Marsden Hospitals, Sutton, United Kingdom

Received 15 October 2008 ,Revised 11 February 2009 ,Accepted 11 February 2009.

Proposed dose–volume constraints for late rectal toxicity. Two constraint sets tested connected by lines.

Proposed dose–volume constraints for late rectal toxicity. Two constraint sets tested connected by lines.
- Full-Size Image
- Download to PowerPoint
Summary of maximal toxicity grade reported (any endpoint) relative to number of constraints failed. Lowest volume constraint taken at each dose level.

Summary of maximal toxicity grade reported (any endpoint) relative to number of constraints failed. Lowest volume constraint taken at each dose level.
- Full-Size Image
- Download to PowerPoint

Note—An online CME test for this article can be taken at http://asro.astro.org under Continuing Education.

Supported and coordinated by the U.K. Medical Research Council, Institute of Cancer Research, and Cancer Research U.K. Section of Radiotherapy Grant C46/A2131.

Conflict of interest: M. Sydes and R. Morgan are employed by the trial sponsor (Medical Research Council United Kingdom).

PII: S0360-3016(09)00254-5

doi: 10.1016/j.ijrobp.2009.02.025

« Previous Next » International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3 , Pages 747-754 , 1 March 2010