International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3 , Pages 704-712 , 1 March 2010

Does the Entire Uterus Need to be Treated in Cancer of the Cervix? Role of Adaptive Brachytherapy

Presented at the American Society of Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Boston, Massachusetts, September 2008.

Received 11 December 2008 ,Revised 5 February 2009 ,Accepted 11 February 2009.

References 

  1. Beadle BM, Jhingran A, Salehpour M, et al. Cervix regression and motion during the course of external beam chemoradiation for cervical cancer. Int J Radiat Oncol Biol Phys. 2009;73:235–241
  2. Lee CM, Shrieve DC, Gaffney DK. Rapid involution and mobility of carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2004;58:625–630
  3. Lin LL, Yang Z, Mutic S, et al. FDG-PET imaging for the assessment of physiologic volume response during radiotherapy in cervix cancer. Int J Radiat Oncol Biol Phys. 2006;65:177–181
  4. Mayr NA, Taoka T, Yuh WT, et al. Method and timing of tumor volume measurement for outcome prediction in cervical cancer using magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2002;52:14–22
  5. Nam H, Park W, Huh SJ, et al. The prognostic significance of tumor volume regression during radiotherapy and concurrent chemoradiotherapy for cervical cancer using MRI. Gynecol Oncol. 2007;107:320–325
  6. Haie-Meder C, Potter R, Van Limbergen E, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol. 2005;74:235–245
  7. Potter R, Haie-Meder C, Van Limbergen E, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78:67–77
  8. Ohara K, Nemoto K, Ohnishi K, et al. Classical tandem-source dwelling covering the entire uterus: Essential in modern intracavitary radiotherapy for cervical cancer?. Radiat Med. 2007;25:386–392
  9. Leborgne F, Fowler JF, Leborgne JH, et al. Biologically effective doses in medium dose rate brachytherapy of cancer of the cervix. Radiat Oncol Investig. 1997;5:289–299
  10. Chen SW, Liang JA, Yang SN, et al. The adverse effect of treatment prolongation in cervical cancer by high-dose-rate intracavitary brachytherapy. Radiother Oncol. 2003;67:69–76
  11. Chung YL, Jian JJ, Cheng SH, et al. Extended-field radiotherapy and high-dose-rate brachytherapy with concurrent and adjuvant cisplatin-based chemotherapy for locally advanced cervical cancer: A phase I/II study. Gynecol Oncol. 2005;97:126–135
  12. Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: An update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol. 2004;22:872–880
  13. Kim YS, Shin SS, Nam JH, et al. Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer. Gynecol Oncol. 2008;108:195–200
  14. Novetsky AP, Einstein MH, Goldberg GL, et al. Efficacy and toxicity of concomitant cisplatin with external beam pelvic radiotherapy and two high-dose-rate brachytherapy insertions for the treatment of locally advanced cervical cancer. Gynecol Oncol. 2007;105:635–640
  15. Ozsaran Z, Kamer S, Yalman D, et al. Treatment results and prognostic factors for cervical cancer patients treated by radiochemotherapy with weekly cisplatin. Eur J Gynaecol Oncol. 2007;28:196–200
  16. Potter R, Dimopoulos J, Bachtiary B, et al. 3D conformal HDR-brachy- and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: Clinical experience with 3 year follow-up. Radiother Oncol. 2006;79:80–86
  17. Rose PG, Ali S, Watkins E, et al. Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: A Gynecologic Oncology Group Study. J Clin Oncol. 2007;25:2804–2810
  18. Shakespeare TP, Lim KH, Lee KM, et al. Phase II study of the American Brachytherapy Society guidelines for the use of high-dose rate brachytherapy in the treatment of cervical carcinoma: Is 45-50.4 Gy radiochemotherapy plus 31.8 Gy in six fractions high-dose rate brachytherapy tolerable?. Int J Gynecol Cancer. 2006;16:277–282
  19. Souhami L, Seymour R, Roman TN, et al. Weekly cisplatin plus external beam radiotherapy and high dose rate brachytherapy in patients with locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 1993;27:871–878
  20. Toita T, Moromizato H, Ogawa K, et al. Concurrent chemoradiotherapy using high-dose-rate intracavitary brachytherapy for uterine cervical cancer. Gynecol Oncol. 2005;96:665–670
  21. Tseng CJ, Chang CT, Lai CH, et al. A randomized trial of concurrent chemoradiotherapy versus radiotherapy in advanced carcinoma of the uterine cervix. Gynecol Oncol. 1997;66:52–58
  22. Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999;17:1339–1348
  23. Ozsaran Z, Yalman D, Yurut V, et al. Radiochemotherapy for patients with locally advanced cervical cancer: Early results. Eur J Gynaecol Oncol. 2003;24:191–194
  24. Chen SW, Liang JA, Hung YC, et al. Concurrent weekly cisplatin plus external beam radiotherapy and high-dose rate brachytherapy for advanced cervical cancer: A control cohort comparison with radiation alone on treatment outcome and complications. Int J Radiat Oncol Biol Phys. 2006;66:1370–1377
  25. Eifel PJ, Moughan J, Erickson B, et al. Patterns of radiotherapy practice for patients with carcinoma of the uterine cervix: A patterns of care study. Int J Radiat Oncol Biol Phys. 2004;60:1144–1153
  26. Perez CA, Grigsby PW, Lockett MA, et al. Radiation therapy morbidity in carcinoma of the uterine cervix: Dosimetric and clinical correlation. Int J Radiat Oncol Biol Phys. 1999;44:855–866
  27. Ferrigno R, dos Santos Novaes PE, Pellizzon AC, et al. High-dose-rate brachytherapy in the treatment of uterine cervix cancer. Analysis of dose effectiveness and late complications. Int J Radiat Oncol Biol Phys. 2001;50:1123–1135
  28. Clark BG, Souhami L, Roman TN, et al. The prediction of late rectal complications in patients treated with high dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 1997;38:989–993
  29. Ogino I, Kitamura T, Okamoto N, et al. Late rectal complication following high dose rate intracavitary brachytherapy in cancer of the cervix. Int J Radiat Oncol Biol Phys. 1995;31:725–734
  30. Toita T, Kakinohana Y, Ogawa K, et al. Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: Analysis of dose and fractionation schedule. Int J Radiat Oncol Biol Phys. 2003;56:1344–1353
  31. Fellner C, Potter R, Knocke TH, et al. Comparison of radiography- and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects. Radiother Oncol. 2001;58:53–62
  32. Dewitt KD, Hsu IC, Speight J, et al. 3D inverse treatment planning for the tandem and ovoid applicator in cervical cancer. Int J Radiat Oncol Biol Phys. 2005;63:1270–1274
  33. Potter R, Dimopoulos J, Kirisits C, et al. Recommendations for image-based intracavitary brachytherapy of cervix cancer: The GYN GEC ESTRO Working Group point of view: In regard to Nag, et al. (Int J Radiat Oncol Biol Phys 2004;60:1160–1172). Int J Radiat Oncol Biol Phys. 2005;62:293–295author reply 295–296
  34. Kirisits C, Potter R, Lang S, et al. Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2005;62:901–911
  35. Saarnak AE, Boersma M, van Bunningen BN, et al. Inter-observer variation in delineation of bladder and rectum contours for brachytherapy of cervical cancer. Radiother Oncol. 2000;56:37–42
  36. Schoeppel SL, LaVigne ML, Martel MK, et al. Three-dimensional treatment planning of intracavitary gynecologic implants: Analysis of ten cases and implications for dose specification. Int J Radiat Oncol Biol Phys. 1994;28:277–283
  37. van den Bergh F, Meertens H, Moonen L, et al. The use of a transverse CT image for the estimation of the dose given to the rectum in intracavitary brachytherapy for carcinoma of the cervix. Radiother Oncol. 1998;47:85–90
  38. Wachter-Gerstner N, Wachter S, Reinstadler E, et al. Bladder and rectum dose defined from MRI based treatment planning for cervix cancer brachytherapy: Comparison of dose-volume histograms for organ contours and organ wall, comparison with ICRU rectum and bladder reference point. Radiother Oncol. 2003;68:269–276
  39. Michalski JM, Purdy JA, Winter K, et al. Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406. Int J Radiat Oncol Biol Phys. 2000;46:391–402

 Conflict of interest: none.

PII: S0360-3016(09)00340-X

doi: 10.1016/j.ijrobp.2009.02.044

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3 , Pages 704-712 , 1 March 2010