International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 2 , Pages 496-503 , 1 February 2010

Factors Associated With Neurological Recovery of Brainstem Function Following Postoperative Conformal Radiation Therapy for Infratentorial Ependymoma

  • Thomas E. Merchant, D.O., Ph.D.

      Affiliations

    • Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
    • Corresponding Author InformationReprint requests to: Thomas E. Merchant, D.O., Ph.D., Division of Radiation Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678. Tel: (901) 595-3604; Fax: (901) 595-3113
    • ,
  • Ramana M. Chitti, M.D.

      Affiliations

    • Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
    • ,
  • Chenghong Li, Ph.D., M.S.

      Affiliations

    • Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee
    • ,
  • Xiaoping Xiong, Ph.D.

      Affiliations

    • Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee
    • ,
  • Robert A. Sanford, M.D.

      Affiliations

    • Semmes-Murphy Neurological Institute, Memphis, Tennessee
    • ,
  • Raja B. Khan, M.D.

      Affiliations

    • Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee

Received 25 November 2008 ,Revised 21 December 2008 ,Accepted 29 January 2009.

References 

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  2. Merchant TE, Haida T, Wang MH, Finlay JL, Leibel SA. Anaplastic ependymoma: Treatment of pediatric patients with or without craniospinal radiation therapy. J Neurosurg. 1997;86:943–949
  3. Pollack IF, Gerszten PC, Martinez AJ, et al. Intracranial ependymomas of childhood: Long-term outcome and prognostic factors. Neurosurgery. 1995;37(4):655–666
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  5. Merchant TE, Mulhern RK, Krasin MJ, et al. Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol. 2004;22(15):3156–3162
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  10. Undjian S, Marinov M. Intracranial ependymomas in children. Childs Nerv Syst. 1990;6:131–134
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  12. Merchant TE, Lee H, Zhu J, et al. The effects of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy. J Neurosurg. 2004;101(Suppl 2):159–168
  13. Casey AT, Kimmings EJ, Kleinlugtebeld AD, et al. The long-term outlook for hydrocephalus in childhood. A ten-year cohort study of 155 patients. Pediatr Neurosurg. 1997;27(2):63–70
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  15. Vinchon M, Dhellemmes P. Cerebrospinal fluid shunt infection: risk factors and long-term follow-up. Childs Nerv Syst. 2006;22(7):692–697
  16. Debus J, Hug EB, Liebsch NJ, et al. Brainstem tolerance to conformal radiotherapy of skull base tumors. Int J Radiat Oncol Biol Phys. 1997;39(5):967–975
  17. Jian JJ, Cheng SH, Tsai SY, et al. Improvement of local control of T3 and T4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys. 2002;53(2):344–352

 This work was supported in part by the American Lebanese Syrian Associated Charities (ALSAC) and the American Cancer Society.

 Conflict of interest: none.

PII: S0360-3016(09)00342-3

doi: 10.1016/j.ijrobp.2009.01.079

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 2 , Pages 496-503 , 1 February 2010

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