International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 4 , Pages 1037-1044 , 15 March 2010

Feasibility and Efficacy of Single Photon Emission Computed Tomography-Based Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma 8 cm or More With Portal Vein Tumor Thrombus in Combination With Transcatheter Arterial Chemoembolization

  • Shintaro Shirai, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Morio Sato, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • Corresponding Author InformationReprint requests to: Morio Sato, Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama Shi, Wakayama 641-8510, Japan. Tel: (+81) 73-441-0604; Fax: (+81) 73-444-3110
    • ,
  • Kazuhiro Suwa, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Kazushi Kishi, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Chigusa Shimono, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Tetsuo Sonomura, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Nobuyuki Kawai, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Hirohiko Tanihata, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Hiroki Minamiguchi, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan
    • ,
  • Motoki Nakai, M.D.

      Affiliations

    • Department of Radiology, Wakayama Medical University, Wakayama, Japan

Received 31 October 2008 ,Revised 17 February 2009 ,Accepted 4 March 2009.

References 

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  2. Arata S, Tanaka K, Okazaki H, et al. Risk factors for recurrence of large HCC in patients treated by combined TAE and PEI. Hepatogastroenterology. 2001;48:480–485
  3. Group d'Etude et de Traitement de Carcinome Hepatocellulaire. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med. 1995;332:1256–1261
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  8. Nanashima A, Yamaguchi H, Shibasaki S, et al. Relationship between CT volumetry and functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization before major hepatectomy: A preliminary study. Dig Dis Sci. 2006;51:1190–1195
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  11. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21:109–122
  12. Park W, Lim DH, Paik SW, et al. Local radiotherapy for patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:1143–1150
  13. Park HC, Seong J, Han KH, et al. Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2002;54:150–155
  14. Kim TH, Kim DY, Park JW, et al. Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2007;67:225–231
  15. Liang SX, Zhu XD, Xu ZY, et al. Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys. 2006;65:426–434
  16. Shirai S, Kishi K, Shimono T, et al. Radiation therapy (RT) for hepatocellular carcinoma (HCC) with portal tumor thrombi (PVTT) of main portal vein and/or the 1st branch (in Japanese). Jpn J Clin Radiol. 2006;51:1189–1195

 Conflict of interest: none.

PII: S0360-3016(09)00458-1

doi: 10.1016/j.ijrobp.2009.03.023

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 4 , Pages 1037-1044 , 15 March 2010

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