International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1002-1005 , 15 July 2009

Bath and Shower Effects in the Rat Parotid Gland Explain Increased Relative Risk of Parotid Gland Dysfunction After Intensity-Modulated Radiotherapy

  • Peter van Luijk, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • Corresponding Author InformationReprint requests to: Peter van Luijk, Ph.D., P.O. Box 30001, 9700 RB, Groningen, The Netherlands. Tel: +31-50-3611739; Fax: +31-50-3611692
    • ,
  • Hette Faber

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • ,
  • Jacobus M. Schippers, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • Accelerator Department, Paul Scherrer Institut, Villigen, Switzerland
    • ,
  • Sytze Brandenburg, Ph.D.

      Affiliations

    • Kernfysisch Versneller Instituut, University of Groningen, Groningen, the Netherlands
    • ,
  • Johannes A. Langendijk, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • ,
  • Harm Meertens, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • ,
  • Robert P. Coppes, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    • Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

Received 5 March 2009 ,Revised 13 March 2009 ,Accepted 15 March 2009.

References 

  1. Eisbruch A, Ten Haken RK, Kim HM, et al. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 1999;45:577–587
  2. Dijkema T, Terhaard CH, Roesink JM, et al. Large cohort dose-volume response analysis of parotid gland function after radiotherapy: Intensity-modulated versus conventional radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:1101–1109
  3. Jellema AP, Doornaert P, Slotman BJ, et al. Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?. Radiother Oncol. 2005;77:164–171
  4. Bijl HP, van Luijk P, Coppes RP, et al. Dose-volume effects in the rat cervical spinal cord after proton irradiation. Int J Radiat Oncol Biol Phys. 2002;52:205–211
  5. Bijl HP, van Luijk P, Coppes RP, et al. Unexpected changes of rat cervical spinal cord tolerance caused by inhomogeneous dose distributions. Int J Radiat Oncol Biol Phys. 2003;57:274–281
  6. Bijl HP, van Luijk P, Coppes RP, et al. Regional differences in radiosensitivity across the rat cervical spinal cord. Int J Radiat Oncol Biol Phys. 2005;61:543–551
  7. Bijl HP, van Luijk P, Coppes RP, et al. Influence of adjacent low-dose fields on tolerance to high doses of protons in rat cervical spinal cord. Int J Radiat Oncol Biol Phys. 2006;64:1204–1210
  8. van Luijk P, Bijl HP, Konings AW, et al. Data on dose-volume effects in the rat spinal cord do not support existing NTCP models. Int J Radiat Oncol Biol Phys. 2005;61:892–900
  9. Konings AW, Cotteleer F, Faber H, et al. Volume effects and region-dependent radiosensitivity of the parotid gland. Int J Radiat Oncol Biol Phys. 2005;62:1090–1095
  10. Konings AW, Faber H, Cotteleer F, et al. Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland. Int J Radiat Oncol Biol Phys. 2006;64:98–105
  11. Cotteleer F, Faber H, Konings AW, et al. Three-dimensional dose distribution for partial irradiation of rat parotid glands with 200kV X-rays. Int J Radiat Biol. 2003;79:689–700
  12. van Luijk P, Bijl HP, Coppes RP, et al. Techniques for precision irradiation of the lateral half of the rat cervical spinal cord using 150 MeV protons. Phys Med Biol. 2001;46:2857–2871
  13. van Luijk P, t' Veld AA, Zelle HD, et al. Collimator scatter and 2D dosimetry in small proton beams. Phys Med Biol. 2001;46:653–670
  14. Boon SN, van Luijk P, Schippers JM, et al. Fast 2D phantom dosimetry for scanning proton beams. Med Phys. 1998;25:464–475
  15. Lombaert IM, Brunsting JF, Wierenga PK, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE. 2008;3:e2063

 Conflict of interest: none.

PII: S0360-3016(09)00505-7

doi: 10.1016/j.ijrobp.2009.03.039

International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 4 , Pages 1002-1005 , 15 July 2009

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