Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Woodward, Wendy A.; Bristow, Robert G.; Clarke, Michael F.; Coppes, Robert P.; Cristofanilli, Massimo; Duda, Dan G.; Fike, John R.; Hambardzumyan, Dolores; Hill, Richard P.; Jordan, Craig T.; Milas, Luka; Pajonk, Frank; Curran, Walter J.; Dicker, Adam P.; Chen, Yuhchyau

doi:10.1016/j.ijrobp.2009.03.047

« Previous Next »International Journal of Radiation Oncology * Biology * Physics
Volume 74, Issue 5 , Pages 1580-1591, 1 August 2009

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward, M.D., Ph.D.
- The University of Texas M. D. Anderson Cancer Center, Houston, TX
- Reprint requests to: Wendy A. Woodward, M.D., Ph.D., The University of Texas M. D. Anderson Cancer Center, Department of Radiation Oncology, 1515 Holcombe Blvd, Unit 1202, Houston, TX 77030. Tel: (713) 563-2300; Fax: (713) 563-6940
Robert G. Bristow, M.D., Ph.D., FRCPC
- The Princess Margaret Hospital (University Health Network), Toronto, Ontario
Michael F. Clarke, Ph.D.
- The University of Texas M. D. Anderson Cancer Center, Houston, TX
- Stanford University, Palo Alto, CA
Robert P. Coppes, Ph.D.
- University Medical Center Groningen, The Netherlands
Massimo Cristofanilli, Ph.D.
- The University of Texas M. D. Anderson Cancer Center, Houston, TX
Dan G. Duda, D.M.D., Ph.D.
- Massachusetts General Hospital, Harvard Medical School, Boston, MA
John R. Fike, Ph.D.
- The University of California, San Francisco, CA
Dolores Hambardzumyan, Ph.D.
- The Princess Margaret Hospital (University Health Network), Toronto, Ontario
- Memorial Sloan-Kettering Cancer Center, New York, NY
Richard P. Hill, Ph.D.
- The Princess Margaret Hospital (University Health Network), Toronto, Ontario
Craig T. Jordan, Ph.D.
- The University of Rochester Medical Center, Rochester, NY
Luka Milas, M.D., Ph.D.
- The University of Texas M. D. Anderson Cancer Center, Houston, TX
Frank Pajonk, M.D.
- The University of California, Los Angeles, Los Angeles, CA
Walter J. Curran, M.D.
- Thomas Jefferson University, Philadelphia, PA
Adam P. Dicker, M.D., Ph.D.
- Thomas Jefferson University, Philadelphia, PA
Yuhchyau Chen, PhD., M.D.
- The University of Rochester Medical Center, Rochester, NY

Received 25 February 2009; accepted 3 March 2009. published online 18 June 2009.

At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

Stem cell, Radiation therapy, Cancer, Radiobiology, Clonogens