Extrapulmonary Soft-Tissue Fibrosis Resulting From Hypofractionated Stereotactic Body Radiotherapy for Pulmonary Nodular LesionsPage 349
T. Kawase, A. Takeda, E. Kunieda, M. Kokubo, Y. Kamikubo, R. Ishibashi, T. Nagaoka, N. Shigematsu, and A. Kubo
This article is on extrapulmonary fibrosis developing after hypofractionated stereotactic body radiotherapy (SBRT). This adverse event can cause serious symptoms such as pain, brachial plexus neuropathy, and arm edema. In addition, the fibrosis can spawn a subcutaneous mass that may be confused with recurrence or metastasis in the chest wall. Nine (2.4%) of a total of 379 consecutive patients were found to have extrapulmonary fibrosis.
RTOG GU Radiation Oncology Specialists Reach Consensus on Pelvic Lymph Node Volumes for High-Risk Prostate CancerPage 383
C. A. F. Lawton, J. Michalski, I. El-Naqa, M. K. Buyyounouski, W. R. Lee, C. Menard, E. O'Meara, S. A. Rosenthal, M. Ritter, and M. Seider
IMRT treatment of pelvic lymph nodes in men with high-risk prostate cancer has become a standard of practice. Agreement on which nodal groups to include and nodal volumes to be contoured is an area of great controversy, however. This article is the result of a consensus project involving RTOG GU radiation oncologists who evaluated the data regarding the lymph node drainage of the prostate. They then came to a consensus on nodal volumes that should be contoured and treated for appropriate management of the pelvic lymph nodes in high-risk prostate cancer.
The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell CarcinomasPage 553
C. S. Kong, B. Narasimhan, H. Cao, S. Kwok, J. P. Erickson, A. Koong, N. Pourmand, and Q.-T. Le
Tumors infected with high-risk types of human papillomavirus (HPV) are associated with better overall survival and increased time to progression. However, this study showed that the EGFR status may be helpful in identifying patients with HPV(+) tumors who are more likely to show progression. A small subset of patients with HPV(+)/EGFR(+) tumors had a significantly lower overall 5-year survival rate than did patients with HPV(+)/EGFR(−) tumors. In contrast, the HPV status showed no direct correlation with the tumor oxygenation status and intratumoral inflammation was prognostically significant for only HPV(−) tumors.
Cumulative Lung Dose for Several Motion Management Strategies as a Function of Pretreatment Patient ParametersPage 593
G. D. Hugo, J. Campbell, T. Zhang, and D. Yan
Studies of respiration management techniques often focus on the required safety margins and their effect on plan quality. In this study, it was assumed that all the techniques were perfectly delivered to the patient, and instead, the lung dose was evaluated for each technique. A management technique incorporating the effect of respiration into the safety margins increased lung dose in relation to the other more technically complex approaches as a function of the amount of tumor motion and the dose distribution shape. These results can help select an appropriate motion management strategy based on pretreatment patient data.
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