International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 38-43 , 1 May 2010

Predictive Factors of Late Radiation Fibrosis: A Prospective Study in Non–Small Cell Lung Cancer

  • Renaud Mazeron, M.D.

      Affiliations

    • University of Lyon, Centre Léon Bérard, Department of Radiation Oncology, Lyon, France
  • ,
  • Bénédicte Etienne-Mastroianni, M.D.

      Affiliations

    • Hôpital Louis Pradel, Department of Pneumology, Lyon, France
  • ,
  • David Pérol, M.D.

      Affiliations

    • University of Lyon, Centre Léon Bérard, Departement of Public Health, Lyon, France
  • ,
  • Dominique Arpin, M.D.

      Affiliations

    • Hôpital de la Croix-Rousse, Department of Pneumology, Lyon, France
  • ,
  • Michel Vincent, M.D.

      Affiliations

    • Hôpital Saint Luc-Saint Joseph, Department of Pneumology, Lyon, France
  • ,
  • Lionel Falchero, M.D.

      Affiliations

    • Centre Hospitalier Général, Department of Pneumology, Villefranche sur Saône, France
  • ,
  • Isabelle Martel-Lafay, M.D.

      Affiliations

    • University of Lyon, Centre Léon Bérard, Department of Radiation Oncology, Lyon, France
  • ,
  • Christian Carrie, M.D.

      Affiliations

    • University of Lyon, Centre Léon Bérard, Department of Radiation Oncology, Lyon, France
  • ,
  • Line Claude, M.D.

      Affiliations

    • University of Lyon, Centre Léon Bérard, Department of Radiation Oncology, Lyon, France
    • Corresponding Author InformationReprint requests to: Line Claude, M.D., Centre Léon Bérard, 28 rue Laennec, 69008 Lyon, France. Tel: (+33) 4-78-78-26-49; Fax: (+33) 4-78-78-51-40

Received 27 January 2009 ,Revised 10 April 2009 ,Accepted 10 April 2009.

References 

  1. Kong FM, Hayman JA, Griffith KA, et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys. 2006;65:1075–1086
  2. Claude L, Perol D, Ginestet C, et al. A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: Clinical and dosimetric factors analysis. Radiother Oncol. 2004;71:175–181
  3. Ohe Y, Yamamoto S, Suzuki K, et al. Risk factors of treatment-related death in chemotherapy and thoracic radiotherapy for lung cancer. Eur J Cancer. 2001;37:54–63
  4. Morgan GW, Breit SN. Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury. Int J Radiat Oncol Biol Phys. 1995;31:361–369
  5. Anscher MS, Kong FM, Andrews K, et al. Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 1998;41:1029–1035
  6. Chen Y, Rubin P, Williams J, et al. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2001;49:641–646
  7. Arpin D, Perol D, Blay JY, et al. Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis. J Clin Oncol. 2005;23:8748–8756
  8. International Commission on Radiation Units and Measurements. Prescribing, recording, and reporting photon beam therapy (Report 50). Med Phys. 1994;21:833–834
  9. Pavy JJ, Denekamp J, Letschert J, et al. EORTC Late Effects Working Group. Late effects toxicity scoring: The SOMA scale. Radiother Oncol. 1995;35:11–15
  10. Bentzen SM, Skoczylas JZ, Bernier J. Quantitative clinical radiobiology of early and late lung reactions. Int J Radiat Biol. 2000;76:453–462
  11. Hartsell WF, Scott CB, Dundas GS, et al. Can serum markers be used to predict acute and late toxicity in patients with lung cancer? Analysis of RTOG 91-03. Am J Clin Oncol. 2007;30:368–376
  12. Emami B, Graham GV. In: Lung. Principles and practice of radiation oncology. (3rd ed.). Philadelphia, PA: Lippincott-Raven; 1997;
  13. Marks LB, Munley MT, Bentel GC, et al. Physical and biological predictors of changes in whole-lung function following thoracic irradiation. Int J Radiat Oncol Biol Phys. 1997;39:563–570
  14. Kong FM, Ten Haken R, Eisbruch A, Lawrence TS. Non-small cell lung cancer therapy-related pulmonary toxicity: An update on radiation pneumonitis and fibrosis. Semin Oncol. 2005;32:S42–S54
  15. Hernando M, Marks L, Bentel G, et al. Radiation-induced pulmonary toxicity: A dose-volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys. 2001;51:650–659
  16. Segawa Y, Takigawa N, Kataoka M, et al. Risk factors for development of radiation pneumonitis following radiation therapy with or without chemotherapy for lung cancer. Int J Radiat Oncol Biol Phys. 1997;39:91–98
  17. Tsujino K, Hirota S, Endo M, et al. Predictive value of dose–volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys. 2003;55:110–115
  18. Graham MV, Purdy JA, Emami B, et al. Preliminary results of a prospective trial using three dimensional radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys. 1995;33:993–1000
  19. Kwa SL, Lebesque JV, Theuws JC, et al. Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys. 1998;42:1–9
  20. Johnston CJ, Piedboeuf B, Rubin P, et al. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 1996;145:762–767
  21. Epperly MW, Travis EL, Sikora C, Greenberger JS. Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis. Biol Blood Marrow Transplant. 1999;5:204–214
  22. Vujaskovic Z, Marks LB, Anscher MS. The physical parameters and molecular events associated with radiation-induced lung toxicity. Sem Radiat Oncol. 2000;10:296–307
  23. Martin M, Lefaix J-L, Delanian S. TGFβ1 and radiation fibrosis: A master switch and a specific therapeutic target?. Int J radiat Oncol Biol Phys. 2000;47:277–290
  24. Barthelemy-Brichant N, Bosquee L, Cataldo D, et al. Increased IL-6 and TGF-beta1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy. Int J Radiat Oncol Biol Phys. 2004;58:758–767
  25. Fu XL, Huang H, Bentel G, et al. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int J Radiat Oncol Biol Phys. 2001;50:899–890

 Conflict of interest: none.

PII: S0360-3016(09)00587-2

doi: 10.1016/j.ijrobp.2009.04.019

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 38-43 , 1 May 2010