International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 16-23 , 1 May 2010

Xerostomia After Treatment for Oral and Oropharyngeal Cancer Using the University of Washington Saliva Domain and a Xerostomia-Related Quality-of-Life Scale

  • Simon N. Rogers, F.D.S., R.C.S., F.R.C.S., M.D.

      Affiliations

    • Evidence-Based Practice Research Centre, Faculty of Health, Edge Hill University, Ormskirk, UK
    • Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, UK
    • Corresponding Author InformationReprint requests to: Professor Simon N. Rogers, Evidence-Based Practice Research Centre, Faculty of Health, Edge Hill University, St. Helens Road, Ormskirk, L39 4QP. Tel: (+44) 0151-529-5287; Fax: (+44) 0151-529-5288
    • ,
  • Ian A. Johnson

      Affiliations

    • Faculty of Medicine, University of Liverpool, Liverpool, UK
    • ,
  • Derek Lowe, M.Sc.

      Affiliations

    • Evidence-Based Practice Research Centre, Faculty of Health, Edge Hill University, Ormskirk, UK

Received 7 February 2009 ,Revised 15 April 2009 ,Accepted 15 April 2009.

References 

  1. Rogers SN, Lowe D, Brown JS, et al. A prospective quality of life study in patients treated with primary surgery for oral cancer. Head Neck. 1999;21:394–401
  2. Dirix P, Nuyts S, Vander Poorten V, et al. The influence of xerostomia after radiotherapy on quality of life: Results of a questionnaire in head and neck cancer. Support Care Cancer. 2008;16:171–179
  3. Ringash J, Warde P, Lockwood G, et al. Postradiotherapy quality of life for head-and-neck cancer patients is independent of xerostomia. Int J Radiat Oncol Biol Physics. 2005;61:1403–1407
  4. Rogers SN, Ahad SA, Murphy AP. A structured review and theme analysis of papers published on 'quality of life' in head and neck cancer: 2000 to 2005. Oral Oncol. 2007;43:843–868
  5. Fisher J, Scott C, Scarantino CW, et al. Phase III quality-of-life study results: impact on patients' quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer: RTOG 97-09. Int J Radiat Oncol Biol Physics. 2003;56:832–836
  6. Ng MK, Porceddu SV, Milner AD, et al. Parotid-sparing radiotherapy: Does it really reduce xerostomia?. Clin Oncol (R Coll Radiol). 2005;17:610617
  7. Connor NP, Cohen SB, Kammer RE, et al. Impact of conventional radiotherapy on health-related quality of life and critical functions of the head and neck. Int J Radiat Oncol Biol Physics. 2006;65:1051–1062
  8. Locker D. Dental status, xerostomia and the oral health-related quality of life of an elderly institutionalized population. Spec Care Dentist. 2003;23:86–93
  9. Pace-Balzan A, Cawood JI, Howell R, et al. The further development and validation of the Liverpool Oral Rehabilitation Questionnaire: A cross-sectional survey of patients attending for oral rehabilitation and general dental practice. Int J Oral Maxillofac Surg. 2006;35:72–78
  10. Kahn ST, Johnstone PA. Management of xerostomia related to radiotherapy for head and neck cancer. Oncology (Williston Park). 2005;19:1827–1832discussion 1832–1834, 1837–1839
  11. Duncan GG, Epstein JB, Tu D, et al. Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: A report from the NCIC CTG HN2 randomised trial of an antimicrobial lozenge to prevent mucositis. 2005;27:421–428.
  12. Warde P, Kroll B, O'Sullivan B, et al. A phase II study of Biotene in the treatment of postradiation xerostomia in patients with head and neck cancer. Support Care Cancer. 2000;8:203–208
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  15. Scarantino C, LeVeque F, Swann RS, et al. Effect of pilocarpine during radiation therapy: Results of RTOG 97-09, a phase III randomized study in head and neck cancer patients. J Support Oncol. 2006;4:252–258
  16. Regelink G, Vissink A, Reintsema H, et al. Efficacy of a synthetic polymer saliva substitute in reducing oral complaints of patients suffering from irradiation-induced xerostomia. Quintessence Int. 1998;29:383–388
  17. Shahdad SA, Taylor C, Barclay SC, et al. A double-blind, crossover study of Biotene Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia. Eur J Cancer Care. 2005;14:319–326
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  22. Rogers SN, El-Sheikha J, Lowe D. The development of a Patients Concerns Inventory (PCI) to help raise patients concerns in the head and neck clinic. Oral Oncol. In press.
  23. Millsopp L, Frackleton S, Lowe D, et al. A feasibility study of computer-assisted health-related quality of life data collection in patients with oral and oropharyngeal cancer. Int J Oral Maxillofac Surg. 2006;35:761–764
  24. Rogers SN, Fisher SE, Woolgar JA. A review of quality of life assessment in oral cancer. Int J Oral Maxillofac Surg. 1999;28:99–117
  25. Ringash J, Bezjak A. A structured review of quality of life instruments for head and neck cancer patients. Head Neck. 2001;23:201–213
  26. Rogers SN, Gwane S, Lowe D, et al. The addition of mood and anxiety domains to the University of Washington Quality of Life Scale. Head Neck. 2002;24:521–529
  27. Kanatas AN, Rogers SN. A national survey of health-related quality of life questionnaires in head and neck oncology. Ann R Coll Surg Engl. 2004;86:6–10
  28. Kanatas AN, Mehanna H, Lowe D, et al. A second national survey of health-related quality of life questionnaires in head and neck oncology. Ann R Coll Surg Engl. In press.
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  30. Rogers SN, O'Donnell JP, Williams- Hewitt S, et al. Health-related quality of life measured by the UWQOL: Reference values from a general dental practice. Oral Oncol. 2006;42:281–287
  31. Rogers SN, Lowe D. Screening for dysfunction to promote MDT intervention using the University of Washington Quality of Life questionnaire (UW-QOL). Arch Otolaryngol–Head Neck Surg. 2009;135:369–375
  32. Braam PM, Roesink JM, Raaijmakers CP, et al. Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy. Radiat Oncol. 2007;2:3
  33. Sanchez-Guerrero J, Aguirre-Garcia E, Perez-Dosal MR, et al. The wafer test: A semi-quantitative test to screen for xerostomia. Rheumatology. 2002;41:381–389
  34. Malouf JG, Aragon C, Henson BS, et al. Influence of parotid-sparing radiotherapy on xerostomia in head and neck cancer patients. Cancer Detect Prev. 2003;27:305–310
  35. Eisbruch A, Kim HM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Physics. 2001;50:695–704
  36. Baker SR, Pankhurst CL, Robinson PG. Utility of two oral health-related quality-of-life measures in patients with xerostomia. Community Dent Oral Epidemiol. 2006;34:351–362
  37. Thomson WM, Chalmers JM, Spencer AJ, et al. The Xerostomia Inventory: A multi-item approach to measuring dry mouth. Community Dent Health. 1999;16:12–17
  38. Pace-Balzan A, Butterworth CJ, Dawson LJ, et al. The further development and validation of the Liverpool Oral Rehabilitation Questionnaire (LORQ) version 3: a cross-sectional survey of patients referred to a dental hospital for removable prostheses replacement. J Prosthet Dent. 2008;99:233–242

 Conflict of interest: none.

PII: S0360-3016(09)00589-6

doi: 10.1016/j.ijrobp.2009.04.021

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 16-23 , 1 May 2010

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