International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 220-224 , 1 September 2009

Mobilization of Circulating Vascular Progenitors in Cancer Patients Receiving External Beam Radiation in Response to Tissue Injury

  • David S. Allan, M.Sc., M.D.

      Affiliations

    • Ottawa Health Research Institute, Regenerative Medicine Program, Ottawa, Ontario, Canada
    • Corresponding Author InformationReprint requests to: David S. Allan, M.Sc., M.D., Ottawa Health Research Institute, The Ottawa Hospital, General Campus, 501 Smyth Rd., Box 704, Ottawa, Ontario, K1H 8L6 Canada. Tel: (613) 737-8899; Fax: (613) 737-8861
    • ,
  • Scott C. Morgan, M.D.

      Affiliations

    • The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada
    • Division of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Paul E. Birch, MLT.

      Affiliations

    • Stem Cell Processing Laboratory, Canadian Blood Services, Ottawa, Ontario, Canada
    • ,
  • Lin Yang, B.Sc.

      Affiliations

    • Stem Cell Processing Laboratory, Canadian Blood Services, Ottawa, Ontario, Canada
    • ,
  • Michael J. Halpenny, MLT.

      Affiliations

    • Stem Cell Processing Laboratory, Canadian Blood Services, Ottawa, Ontario, Canada
    • ,
  • Angelo Gunanayagam

      Affiliations

    • Ottawa Health Research Institute, Regenerative Medicine Program, Ottawa, Ontario, Canada
    • ,
  • Yuhua Li, M.Sc.

      Affiliations

    • Ottawa Health Research Institute, Regenerative Medicine Program, Ottawa, Ontario, Canada
    • ,
  • Libni Eapen, M.D.

      Affiliations

    • The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada
    • Division of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada

Received 8 September 2008 ,Revised 21 April 2009 ,Accepted 22 April 2009.

References 

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  2. Peichev M, Naiyer AJ, Pereira D, et al. Expression of VEGFR-2 and AC133 by circulating human CD34 (+) cells identifies a population of functional endothelial precursors. Blood. 2000;95:952–958
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  9. Iqbal T, Rajagopal T, Halpenny M, et al. Increased graft content of vascular progenitor cells is associated with reduced toxicity following autologous hematopoietic transplantation. Exp Hematol. 2008;36:506–512
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  13. National Cancer Institute Common Toxicity Criteria, version 3.0. Posted April 1, 2003. Available at: URL: http://ctep.info.nih.gov/CTC3/ctc.htm. Accessed September 1, 2005.
  14. Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function and cardiovascular risk. N Engl J Med. 2003;348:593–600
  15. Keeney M, Chin-Yee I, Weir K, et al. Single platform flow cytometric absolute CD34+ cell counts based on the ISHAGE guidelines. Cytometry. 1998;34:61–70
  16. Lin Y, Weisdorf DJ, Solovey A, et al. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest. 2000;105:71–77

 Funding for this study was provided by the Ottawa Hospital Cancer Program Foundation.

 Conflict of interest: none.

PII: S0360-3016(09)00595-1

doi: 10.1016/j.ijrobp.2009.04.033

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 1 , Pages 220-224 , 1 September 2009

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