International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 24-30 , 1 May 2010

18F-FDG PET-CT Simulation for Non–Small-Cell Lung Cancer: Effect in Patients Already Staged by PET-CT

  • Gerard G. Hanna, M.B., M.R.C.P., F.R.C.R.

      Affiliations

    • Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom
    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • Corresponding Author InformationReprint requests to: Gerard G. Hanna, M.B., M.R.C.P., F.R.C.R., Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Level 1 Cancer Centre, Belfast City Hospital, Lisburn Rd., Belfast BT9 7AB North Ireland, United Kingdom; Tel: (+44) 028-9069-9299; Fax: (+44) 028-9069-9406
    • ,
  • Jonathan McAleese, M.A., M.R.C.P., F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Kathryn J. Carson, Ph.D.

      Affiliations

    • Northern Ireland Regional Medical Physics Agency, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • David P. Stewart, M.B., M.R.C.P., F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Vivian P. Cosgrove, Ph.D.

      Affiliations

    • Northern Ireland Regional Medical Physics Agency, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Ruth L. Eakin, M.B., F.R.C.P.I., F.R.C.R.

      Affiliations

    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Ashraf Zatari, Ph.D.

      Affiliations

    • Northern Ireland Regional Medical Physics Agency, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Tom Lynch, M.B., F.R.C.R.

      Affiliations

    • Department of Nuclear Medicine, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Peter H. Jarritt, Ph.D.

      Affiliations

    • Northern Ireland Regional Medical Physics Agency, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • V.A. Linda Young, D.C.R.

      Affiliations

    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Joe M. O'Sullivan, M.D., F.R.C.P.I., F.F.R.R.C.S.I.

      Affiliations

    • Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom
    • Department of Clinical Oncology, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
    • ,
  • Alan R. Hounsell, Ph.D.

      Affiliations

    • Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom
    • Northern Ireland Regional Medical Physics Agency, Cancer Centre, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom

Received 4 December 2008 ,Revised 13 April 2009 ,Accepted 14 April 2009.

References 

  1. U.S. Cancer Statistics Working Group . United States Cancer Statistics: 2004 Incidence and Mortality. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Cancer Institute; 2007;
  2. Dwamena BA, Sonnad SS, Angobaldo JO, et al. Metastases from non–small-cell lung cancer: Mediastinal staging in the 1990s—Meta-analytic comparison of PET and CT. Radiology. 1999;213:530–536
  3. Freudenberg LS, Rosenbaum SJ, Beyer T, et al. PET versus PET/CT dual-modality imaging in evaluation of lung cancer. Radiol Clin North Am. 2007;45:639–644
  4. Vanuytsel LJ, Vansteenkiste JF, Stroobandts SG, et al. The impact of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) lymph node staging on the radiation treatment volumes in patients with non–small-cell lung cancer. Radiother Oncol. 2000;55:317–324
  5. Caldwell CB, Mah K, Ung KC, et al. Observer variation in contouring gross tumor volume in patients with poorly defined non–small cell lung tumors on CT: The impact of 18FDG-hybrid PET fusion. Int J Radiat Oncol Biol Phys. 2001;51:923–931
  6. Fox JL, Rengan R, O'Meara W, et al. Does registration of PET and planning CT images decreased interobserver and intraobserver variation in delineating tumor volumes for non–small-cell lung cancer?. Int J Radiat Oncol Biol Phys. 2005;62:70–75
  7. van der Wel A, Nijsten S, Hochstenbag M, et al. Increased therapeutic ratio by 18FDG-PET CT planning in patients with clinical CT stage N2-N3M0 non–small-cell lung cancer: A modeling study. Int J Radiat Oncol Biol Phys. 2005;61:649–655
  8. Grills IS, Yan D, Black QC, et al. Clinical implications of defining the gross tumour volume with combination of CT and 18FDG-positron emission tomography in non–small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2007;67:709–719
  9. van Baardwijk A, Bosmans G, Boersma L, et al. PET-CT–based auto-contouring in non–small-cell lung cancer correlates with pathology and reduces interobserver variability in the delineation of the primary tumour and involved nodal volumes. Int J Radiat Oncol Biol Phys. 2007;68:771–778
  10. Faria SL, Menard S, Devic S, et al. Impact of FDG PET/CT on radiotherapy volume delineation in non–small-cell lung cancer and correlation of imaging stage with pathological findings. Int J Radiat Oncol Biol Phys. 2008;70:1035–1038
  11. Caldwell CB, Mah K, Skinner M, et al. Danjoux CE. Can PET provide the 3D extent of tumor motion for individualized internal target volumes? A phantom study of the limitations of CT and the promise of PET. Int J Radiat Oncol Biol Phys. 2003;55:1381–1393
  12. Fitton I, Steenbakkers RJHM, Gilhuijs K, et al. Impact of anatomical location of value of CT-PET co-registration for delineation of lung tumors. Int J Radiat Oncol Biol Phys. 2008;70:1403–1407
  13. Giraud P, Elles S, Helfre S, et al. Conformal radiotherapy for lung cancer: Different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists. Radiother Oncol. 2002;62:27–36
  14. Mountain CF. Revisions in the international system for staging lung cancer. Chest. 1997;111:1710–1717
  15. Jarritt P, Hounsell A, Carson KJ, et al. Use of combined PET/CT images for radiotherapy planning: Initial experiences in lung cancer. Br J Radiol. 2005;28(Suppl):33–40
  16. Bland JM, Altman DG. Agreement between methods of measurement with multiple observations per individual. J Biopharmaceutic Stat. 2007;17:571–582
  17. Beyer T, Antoch G, Blodgett T, et al. Dual modality PET-CT imaging: The effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med. 2003;30:588–596
  18. Hoesktra CJ, Stroobants SG, Smit EF, et al. Prognostic relevance of response evaluation using [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with locally advanced non–small-cell lung cancer. J Clin Oncol. 2005;23:8362–8370
  19. Gagel B, Piroth M, Pinkawa M, et al. Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET–based target volume definition in locally advanced non-small cell lung cancer: First results of a phase I/II study. BMC Cancer. 2007;7:112

 Supported by the Research and Development Office, Northern Ireland Health and Social Services.

 Conflict of interest: none.

PII: S0360-3016(09)00621-X

doi: 10.1016/j.ijrobp.2009.04.045

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 24-30 , 1 May 2010

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