International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 53-59 , 1 May 2010

Interfraction and Respiratory Organ Motion During Conformal Radiotherapy in Gastric Cancer

  • Barbara Wysocka, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Zahra Kassam, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Gina Lockwood, M.Math.

      Affiliations

    • Department of Biostatics, Princess Margaret Hospital, Toronto, ON, Canada
    • ,
  • James Brierley, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Laura A. Dawson, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Carol Ann Buckley, R.N.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • David Jaffray, Ph.D.

      Affiliations

    • Department of Radiation Physics, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Bernard Cummings, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • John Kim, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Rebecca Wong, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • ,
  • Jolie Ringash, M.D.

      Affiliations

    • Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    • Corresponding Author InformationReprint requests to: Jolie Ringash, M.D., Department of Radiation Oncology, Princess Margaret Hospital, 5th Floor, 610 University Ave., Toronto, ON M5G 2M9 Canada. Tel: (416) 946-4662; Fax: (416) 946-2111

Received 4 December 2008 ,Revised 7 April 2009 ,Accepted 10 April 2009.

References 

  1. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–730
  2. Kassam Z, Lockwood G, O'Brien C, et al. Conformal radiotherapy in the adjuvant treatment of gastric cancer: Review of 82 cases. Int J Radiat Oncol Biol Phys. 2006;65:713–719
  3. Smalley SR, Gunderson L, Tepper J, et al. Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. Int J Radiat Oncol Biol Phys. 2002;52:283–293
  4. Ringash J, Khaksar SJ, Oza A, et al. Post-operative radiochemotherapy for gastric cancer: Adoption and adaptation. Clin Oncol (R Coll Radiol). 2005;17:91–95
  5. Ringash J, Perkins G, Brierley J, et al. IMRT for adjuvant radiation in gastric cancer: A preferred plan?. Int J Radiat Oncol Biol Phys. 2005;63:732–738
  6. Balter JM, Ten Haken RK, Lawrence TS, et al. Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int J Radiat Oncol Biol Phys. 1996;36:167–174
  7. International Commission on Radiation Units and Measurements . ICRU report 62: Prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50). Washington, DC: International Commission on Radiation Units and Measurements; 1999;
  8. Mageras GS, Yorke E. Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol. 2004;14:65–75
  9. Wong JW, Sharpe MB, Jaffray DA, et al. The use of active breathing control (ABC) to reduce margin for breathing motion. Int J Radiat Oncol Biol Phys. 1999;44:911–919
  10. Diez S, Garcia J, Sendra F. Analysis and evaluation of periodic physiological organ motion in radiotherapy treatments. Radiother Oncol. 2004;73:325–329
  11. Gierga DP, Chen GT, Kung JH, et al. Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions. Int J Radiat Oncol Biol Phys. 2004;58:1584–1595
  12. Aruga T, Itami J, Aruga M, et al. Target volume definition for upper abdominal irradiation using CT scans obtained during inhale and exhale phases. Int J Radiat Oncol Biol Phys. 2000;48:465–469
  13. Brandner ED, Wu A, Chen H, et al. Abdominal organ motion measured using 4D CT. Int J Radiat Oncol Biol Phys. 2006;65:554–560
  14. Rietzel E, Rosenthal SJ, Gierga DP, et al. Moving targets: Detection and tracking of internal organ motion for treatment planning and patient set-up. Radiother Oncol. 2004;73(Suppl. 2):S68–S72
  15. Allison RR, Gay HA, Mota HC, et al. Image-guided radiation therapy: Current and future directions. Future Oncol. 2006;2:477–492
  16. Ahmad NR, Huq MS, Corn BW. Respiration-induced motion of the kidneys in whole abdominal radiotherapy: Implications for treatment planning and late toxicity. Radiother Oncol. 1997;42:87–90
  17. Brandner ED, Heron D, Wu A, et al. Localizing moving targets and organs using motion-managed CTs. Med Dosim. 2006;31:134–140
  18. Langen KM, Jones DT. Organ motion and its management. Int J Radiat Oncol Biol Phys. 2001;50:265–278
  19. Giraud P, Yorke E, Ford EC, et al. Reduction of organ motion in lung tumors with respiratory gating. Lung Cancer. 2006;51:41–51
  20. Breen SL, Publicover J, De Silva S, et al. Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers. Int J Radiat Oncol Biol Phys. 2007;68:763–770
  21. Li XA, Qi XS, Pitterle M, et al. Interfractional variations in patient setup and anatomic change assessed by daily computed tomography. Int J Radiat Oncol Biol Phys. 2007;68:581–591
  22. Isobe K, Uno T, Kawakami H, et al. A case of gastric lymphoma with marked interfractional gastric movement during radiation therapy. Int J Clin Oncol. 2006;11:159–161
  23. Wade OL. Movements of the thoracic cage and diaphragm in respiration. J Physiol. 1954;124:193–212
  24. Weiss PH, Baker JM, Potchen EJ. Assessment of hepatic respiratory excursion. J Nucl Med. 1972;13:758–759
  25. Harauz G, Bronskill MJ. Comparison of the liver's respiratory motion in the supine and upright positions: Concise communication. J Nucl Med. 1979;20:733–735
  26. Bryan PJ, Custar S, Haaga JR, et al. Respiratory movement of the pancreas: An ultrasonic study. J Ultrasound Med. 1984;3:317–320
  27. Davies SC, Hill AL, Holmes RB, et al. Ultrasound quantitation of respiratory organ motion in the upper abdomen. Br J Radiol. 1994;67:1096–1102
  28. Suramo I, Paivansalo M, Myllyla V. Cranio-caudal movements of the liver, pancreas and kidneys in respiration. Acta Radiol Diagn (Stockh). 1984;25:129–131
  29. Bussels B, Goethals L, Feron M, et al. Respiration-induced movement of the upper abdominal organs: A pitfall for the three-dimensional conformal radiation treatment of pancreatic cancer. Radiother Oncol. 2003;68:69–74
  30. Korin HW, Ehman RL, Riederer SJ, et al. Respiratory kinematics of the upper abdominal organs: A quantitative study. Magn Reson Med. 1992;23:172–178
  31. Moerland MA, van den Bergh AC, Bhagwandien R, et al. The influence of respiration induced motion of the kidneys on the accuracy of radiotherapy treatment planning, a magnetic resonance imaging study. Radiother Oncol. 1994;30:150–154
  32. Rietzel E, Liu AK, Doppke KP, et al. Design of 4D treatment planning target volumes. Int J Radiat Oncol Biol Phys. 2006;66:287–295
  33. van Sornsen de Koste JR, Senan S, Kleynen CE, et al. Renal mobility during uncoached quiet respiration: An analysis of 4DCT scans. Int J Radiat Oncol Biol Phys. 2006;64:799–803

 B. Wysocka is currently with the Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

 Conflict of interest: none.

PII: S0360-3016(09)00622-1

doi: 10.1016/j.ijrobp.2009.04.046

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 53-59 , 1 May 2010

Article Tools

* Image Usage & Resolution