International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 203-209 , 1 May 2010

Improved Survival With Radiation Therapy in High-Grade Soft Tissue Sarcomas of the Extremities: A SEER Analysis

  • Matthew Koshy, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
    • Corresponding Author InformationReprint requests to: Matthew Koshy, M.D., Department of Radiation Oncology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201. Tel: (410) 328-6080; Fax: (410) 328-5279
    • ,
  • Shayna E. Rich, M.A.

      Affiliations

    • Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Majid M. Mohiuddin, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD

Received 6 January 2009 ,Revised 10 April 2009 ,Accepted 14 April 2009.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Mann GB, Lewis JJ, Brennan MF. Adult soft tissue sarcoma. Aust N Z J Surg. 1999;69:336–343
  3. Storm HH. Survival of adult patients with cancer of soft tissues or bone in Europe. EUROCARE working group. Eur J Cancer. 1998;34:2212–2217
  4. Muhic A, Hovgaard D, Mork Petersen M, et al. Local control and survival in patients with soft tissue sarcomas treated with limb sparing surgery in combination with interstitial brachytherapy and external radiation. Radiother Oncol. 2008;88:382–387
  5. Leibel SA, Tranbaugh RF, Wara WM, et al. Soft tissue sarcomas of the extremities: Survival and patterns of failure with conservative surgery and postoperative irradiation compared to surgery alone. Cancer. 1982;50:1076–1083
  6. Lindberg RD, Martin RG, Romsdahl MM, et al. Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas. Cancer. 1981;47:2391–2397
  7. Fein DA, Lee WR, Lanciano RM, et al. Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation: Do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control?. Int J Radiat Oncol Biol Phys. 1995;32:969–876
  8. Abbatucci JS, Boulier N, de Ranieri J, et al. Local control and survival in soft tissue sarcomas of the limbs, trunk walls and head and neck: A study of 113 cases. Int J Radiat Oncol Biol Phys. 1986;12:579–586
  9. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: Prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982;196:305–315
  10. Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197–203
  11. Trovik CS, Scanadinavian Sarcoma Group Project . Local recurrence of soft tissue sarcoma. A Scandinavian Sarcoma Group project. Acta Orthop Scand Suppl. 2001;72:1–31
  12. Pisters PW, Harrison LB, Leung DH, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14:859–868
  13. Jebsen NL, Trovik CS, Bauer HC, et al. Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: A Scandinavian Sarcoma Group study. Int J Radiat Oncol Biol Phys. 2008;71:1196–1203
  14. Gutierrez JC, Perez EA, Franceschi D, et al. Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry. J Surg Res. 2007;141:105–114
  15. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–20106
  16. Tereffe W, Lang JE, Rao R, et al. Local radiotherapy improves survival in stage IV breast cancer patients who undergo surgical resection of the primary tumor. Int J Radiat Oncol Biol Phys. 2008;72:S156
  17. O'Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: A randomised trial. Lancet. 2002;359:2235–2241
  18. Clarkson P, Ferguson PC. Primary multidisciplinary management of extremity soft tissue sarcomas. Curr Treat Options Oncol. 2004;5:451–462
  19. O'Sullivan B, Pisters PW. Staging and prognostic factor evaluation in soft tissue sarcoma. Surg Oncol Clin N Am. 2003;12:333–353
  20. Mankin HJ, Mankin CJ, Simon MA. The hazards of the biopsy, revisited. Members of the Musculoskeletal Tumor Society. J Bone Joint Surg Am. 1996;78:656–663
  21. Noria S, Davis A, Kandel R, et al. Residual disease following unplanned excision of soft-tissue sarcoma of an extremity. J Bone Joint Surg Am. 1996;78:650–655
  22. Bhangu AA, Beard JA, Grimer RJ. Should soft tissue sarcomas be treated at a specialist centre?. Sarcoma. 2004;8:1–6
  23. Yu JB, Gross CP, Wilson LD, et al. NCI SEER public-use data: Applications and limitations in oncology research. Oncology. 2009;23:288–295
  24. Sarcoma Meta-analysis Collaboration (SMAC). Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Cochrane Database Syst Rev. 2000;(4):CD001419
  25. Figueredo A, Bramwell VH, Bell R, et al. Adjuvant chemotherapy following complete resection of soft tissue sarcoma in adults: A clinical practice guideline. Sarcoma. 2002;6:5–18
  26. Frustaci S, Gherlinzoni F, De Paoli A, et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: Results of the Italian randomized cooperative trial. J Clin Oncol. 2001;19:1238–1247
  27. Tierney JF, Mosseri V, Stewart LA, et al. Adjuvant chemotherapy for soft-tissue sarcoma: Review and meta-analysis of the published results of randomised clinical trials. Br J Cancer. 1995;72:469–475
  28. Davis AM, O'Sullivan B, Turcotte R, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75:48–53

 Supported (S.R.) by training grant T32 AG000262 from the National Institute on Aging, Bethesda, MD.

 Conflict of interest: none.

PII: S0360-3016(09)00649-X

doi: 10.1016/j.ijrobp.2009.04.051

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 1 , Pages 203-209 , 1 May 2010

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