« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3
, Pages 670-676
, 1 July 2010
Chemoradiotherapy of Newly Diagnosed Glioblastoma With Intensified Temozolomide
References
- Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–996
- . MGMT: Its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer. 2004;4:296–307
- MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352:997–1003
- Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Br J Cancer. 2003;88:1004–1011
- Is protracted low-dose temozolomide feasible in glioma patients?. Neurology. 2006;66:427–429
- Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma. J Clin Oncol. 2007;25:3357–3361
- A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer. 2000;83:588–593
- . Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: A rational advance?. J Natl Cancer Inst. 2003;95:1440–1452
- Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. Cancer Res. 1994;54:5602–5606
- Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. Cancer Res. 2001;61:7689–7696
- Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res. 2003;63:8351–8359
- Cyclooxygenase-2 expression in human gliomas: Prognostic significance and molecular correlations. Cancer Res. 2001;61:4375–4381
- Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme: Phase I/II study. Strahlenther Onkol. 2005;181:372–377
- Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol. 1990;8:1277–1280
- . Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
- Nomograms for predicting survival of patients with newly diagnosed glioblastoma: Prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3. Lancet Oncol. 2008;9:29–38
- Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med. 2000;343:1350–1354
- Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma [Abstract]. J Clin Oncol. 2007;25(Suppl.):18S
- Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. J Clin Oncol. 2006;24:4412–4417
- Radiotherapy and temozolomide for newly diagnosed glioblastoma: Recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol. 2006;24:2563–2569
- A phase II study of temozolomide administered 21 out of 28 days for the treatment of patients with recurrent anaplastic (oligo)astrocytoma: An interim analysis of toxicity [Abstract]. J Clin Oncol. 2005;23(Suppl.):16S
- Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: Phase II study from Gruppo Italiano Cooperativo di Neuro-oncologia (GICNO). Br J Cancer. 2006;95:1155–1160
- Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide. J Clin Oncol. 2007;25:1470–1475
- Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J Clin Oncol. 2005;23:2372–2377
Supported by the University of Tübingen Medical Center, Tübingen, Germany.
Conflict of interest: U. Herrlinger, M. Weller, and W. Wick have been consultants to, and have received honoraria from, Schering-Plough.
PII: S0360-3016(09)00794-9
doi: 10.1016/j.ijrobp.2009.05.031
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3
, Pages 670-676
, 1 July 2010
