Fractionated Stereotactic Radiotherapy Treatment of Cavernous Sinus Meningiomas: A Study of 100 CasesPage 1012
C. F. Litre´, P. Colin, R. Noudel, P. Peruzzi, A. Bazin, B. Sherpereel, M. H. Bernard, and P. Rousseaux
In this study, the authors monitored 100 patients with cavernous sinus meningiomas treated with fractionated stereotactic radiotherapy (FSR). No side effects related to the FSR were encountered during a mean follow-up period of 33 months. The tumor control rate was 94% at 3 years. The authors concluded that FSR facilitates tumor control, either as an initial treatment or in combination with microsurgery. FSR also offers the significant benefit of superior functional outcomes.
Motion Analysis of 100 Mediastinal Lymph Nodes: Potential Pitfalls in Treatment Planning and Adaptive StrategiesPage 1092
J. R. Pantarotto, A. H. M. Piet, A. Vincent, J. R. van Sörnsen de Koste, and S. Senan
The intrafraction motion of primary lung tumors is a well-recognized problem, and motion-management strategies have evolved to ensure optimal target coverage. As there are limited data on mediastinal lymph node motion, the authors studied 100 lymph nodes that were identified on 4-dimensional CT scans of 41 patients with lung cancer. This analysis revealed that nodal motion was significant, with 10% of all nodes moving greater than 1 cm, and nodal motion often differing from that of the corresponding primary tumor. The finding suggests that nodal motion should be accounted for during treatment planning for thoracic malignancies.
Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate CancerPage 1217
Y. Dai, J. T. DeSano, Y. Meng, Q. Ji, M. Ljungman, T. S. Lawrence, and L. Xu
Celastrol, an active ingredient of traditional herbal medicine, has recently been identified as a potent natural proteasome inhibitor. In this study, the authors evaluated the radiosensitizing potential of Celastrol in a human prostate cancer model. Celastrol potently sensitized prostate cancer cells to radiation, both in vitro and in vivo, by impairing DNA damage processing as well as by augmenting apoptosis. In a prostate cancer animal model, Celastrol significantly sensitized the tumors to X-ray radiation without increasing systemic toxicity. The study suggests that Celastrol represents a promising new treatment, in combination with radiation, for hormone-refractory prostate cancer.
Tissue Feature-Based and Segmented Deformable Image Registration for Improved Modeling of Shear Movement of LungsPage 1256
Y. Xie, M. Chao, and L. Xing
The differential motion of organs in the thorax makes the modeling of tissue deformation intractable. Current approaches tacitly ignore this and model the system by intensity-based interpolation, which leads to enormous uncertainty in deformable registration. Physics-based models such as the finite element method is, in principle, capable of handling this, provided that manually segmentation can be done on both input images efficiently without any inconsistency and that the tissues' mechanical parameters are known. This work proposes, for the first time, a tissue feature-based registration strategy with explicit inclusion of the differential motions. The technique allows segmented registration without delineating the target phase and greatly increases the robustness and accuracy of the registration. Given the increased interest in 4D and adaptive radiation therapy, the method described here should find useful application in future practice.
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