International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 1 , Pages 287-295 , January 2010

Volumetric Modulated Arc Therapy Improves Dosimetry and Reduces Treatment Time Compared to Conventional Intensity-Modulated Radiotherapy for Locoregional Radiotherapy of Left-Sided Breast Cancer and Internal Mammary Nodes

Presented at the 50th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, MA, Sep 21–25, 2008.

  • Carmen C. Popescu, M.S.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Island Centre, Victoria, British Columbia, Canada
    • Corresponding Author InformationReprint requests to: Carmen Popescu, BC Cancer Agency-Vancouver Island Centre, 2410 Lee Avenue, Victoria, BC, Canada V8R 6V5. Tel: (250) 519-5627; Fax: (250) 519-2024
    • ,
  • Ivo A. Olivotto, M.D.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Island Centre, Victoria, British Columbia, Canada
    • Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Wayne A. Beckham, Ph.D.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Island Centre, Victoria, British Columbia, Canada
    • Physics and Astronomy Department, University of Victoria, Victoria, British Columbia, Canada
    • ,
  • Will Ansbacher, Ph.D.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Island Centre, Victoria, British Columbia, Canada
    • Physics and Astronomy Department, University of Victoria, Victoria, British Columbia, Canada
    • ,
  • Sergei Zavgorodni, Ph.D.

      Affiliations

    • Physics and Astronomy Department, University of Victoria, Victoria, British Columbia, Canada
    • ,
  • Richard Shaffer, F.R.C.P.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Centre, Vancouver, British Columbia, Canada
    • ,
  • Elaine S. Wai, M.D.

      Affiliations

    • Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Karl Otto, Ph.D.

      Affiliations

    • Radiation Therapy Program, British Columbia Cancer Agency–Vancouver Centre, Vancouver, British Columbia, Canada

Received 12 December 2008 ,Revised 13 May 2009 ,Accepted 19 May 2009.

References 

  1. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–2106
  2. Gyenes G, Rutqvist LE, Liedberg A, et al. Long-term cardiac morbidity and mortality in a randomized trial of pre- and postoperative radiation therapy versus surgery alone in primary breast cancer. Radiother Oncol. 1998;48:185–190
  3. Paszat LF, Mackillop WJ, Groome PA, et al. Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: A population-based study in Ontario, Canada. Int J Radiat Oncol Biol Phys. 1999;43:755–762
  4. Vallis KA, Pintilie M, Chong N, et al. Assessment of coronary heart disease morbidity and mortality after radiation therapy for early breast cancer. J Clin Oncol. 2002;20:1036–1042
  5. Darby SC, McGale P, Taylor CW, et al. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: Prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol. 2005;6:557–565
  6. Marks LB, Hebert ME, Bentel G, et al. To treat or not to treat the internal mammary nodes: A possible compromise. Int J Radiat Oncol Biol Phys. 1994;29:903–909
  7. Low JA, Berman AW, Steinberg SM, et al. Long-term follow-up for locally advanced and inflammatory breast cancer patients treated with multimodality therapy. J Clin Oncol. 2004;22:4067–4074
  8. Hortobagyi GN. Trastuzumab in the treatment of breast cancer. N Engl J Med. 2005;353:1734–1736
  9. Popescu CC, Olivotto I, Patenaude V, et al. Inverse-planned, dynamic, multi-beam, intensity-modulated radiation therapy (IMRT): A promising technique when target volume is the left breast and internal mammary lymph nodes. Med Dosim. 2006;31:283–291
  10. Beckham WA, Popescu CC, Patenaude VV, et al. Is multibeam IMRT better than standard treatment for patients with left-sided breast cancer?. Int J Radiat Oncol Biol Phys. 2007;69:918–924
  11. Wai ES, Wells DM, Bendorffe B, et al. Phase II study of a deep inspiration breath hold (DIBH) and intensity modulated radiation therapy (IMRT) treatment for women with left-sided breast cancer. [Abstract] Int J Radiat Oncol Biol Phys. 2008;72:S90
  12. Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008;35:310–317
  13. Otto K, Milette M, Wu J. Temporal delivery efficiency of a novel single gantry arc optimization technique for treatment of recurrent nasopharynx cancer. [Abstract] Int J Radiat Oncol Biol Phys. 2007;69:S703
  14. Palma D, Vollans E, James K, et al. Volumetric modulated arc therapy for delivery of prostate radiotherapy: Comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:996–1001
  15. Fogliata A, Clivio A, Nicolini G, et al. Intensity modulation with photons for benign intracranial tumours: A planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol. 2008;89:180–191
  16. Batho HF. Lung corrections in cobalt 60 beam therapy. J Can Ass Radiol. 1964;15:79
  17. Baltas D, Kolotas C, Geramani K, et al. A conformal index (COIN) to evaluate implant quality and dose specification in brachytherapy. Int J Radiat Oncol Biol Phys. 1998;40:515–524
  18. Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys. 1999;26:1100
  19. Burman C, Kutcher GJ, Emami B, et al. Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys. 1991;21:123–135
  20. Kim Y, Parda DS, Trombetta MG, et al. Dosimetric comparison of partial and whole breast external beam irradiation in the treatment of early stage breast cancer. Med Phys. 2007;34:4640–4648
  21. Marks LB, Yu X, Prosnitz RG, et al. The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys. 2005;63:214–223
  22. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26:2085–2092
  23. Yorke ED, Jackson A, Rosenzweig KE, et al. Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys. 2005;63:672–682
  24. Stovall M, Smith SA, Langholz BM, et al. Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study. Int J Radiat Oncol Biol Phys. 2008;72:1021–1030
  25. Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet. 1998;351:1451–1467
  26. Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys. 2006;65:1–7
  27. Hall EJ, Wuu CS. Radiation-induced second cancers: The impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys. 2003;56:83–88

 Conflict of interest: Karl Otto received salary and research support from Varian Medical Systems, Inc.

PII: S0360-3016(09)00815-3

doi: 10.1016/j.ijrobp.2009.05.038

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 1 , Pages 287-295 , January 2010

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