International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 364-368 , 1 October 2009

Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

  • Robert C. Miller, M.D.

      Affiliations

    • Corresponding Author InformationReprint requests to: Robert C. Miller, M.D., Department of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Tel: (507) 284-2949; Fax: (507) 284-0079
  • ,
  • Matthew J. Iott, F.N.P.-B.C.
  • ,
  • Michele M. Corsini, M.D.

Received 25 August 2008 ,Revised 19 November 2008 ,Accepted 22 November 2008.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
  2. Lim J, Chien M, Earle C. Prognostic factors following curative resection for pancreatic adenocarcinoma: A population-based, linked database analysis of 396 patients. Ann Surg. 2003;237:74–85
  3. Trede M, Schwall G, Saeger H. Survival after pancreatoduodenectomy: 118 consecutive resections without an operative mortality. Ann Surg. 1990;211:447–458
  4. Geer R, Brennan M. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Ann Surg. 1993;165:68–72
  5. Crist D, Sitzmann J, Cameron J. Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg. 1988;206:358–365
  6. Kalser MH, Ellenberg SS. Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985;120:899–903
  7. Klinkenbijl JH, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999;230:776–782discussion 782–774
  8. Neoptolemos JP, Dunn JA, Stocken DD, et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial. Lancet. 2001;358:1576–1585
  9. Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004;350:1200–1210
  10. Corsini MM, Miller RC, Haddock MG, et al. Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma: The Mayo Clinic experience (1975-2005). J Clin Oncol. 2008;26:3511–3516
  11. Gunderson L, Martenson J, Smalley S, et al. Upper gastrointestinal cancers: Rationale, results, and techniques of treatment. Front Radiat Ther Oncol. 1994;28:121–139
  12. Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer. 1987;59:2006–2010
  13. Garofalo MC, Regine WF, Tan MT. On statistical reanalysis, the EORTC trial is a positive trial for adjuvant chemoradiation in pancreatic cancer. Ann Surg. 2006;244:332–333author reply 333
  14. Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial. JAMA. 2008;299:1019–1026
  15. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA. 2007;297:267–277

 Presented at the 5th Japan-US Cancer Therapy Symposium and the 5th S. Takahashi Memorial International Joint Symposium, September 7th, 2007

 Conflict of interest: none.

PII: S0360-3016(09)00841-4

doi: 10.1016/j.ijrobp.2008.11.069

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 364-368 , 1 October 2009