International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 338-342 , 1 October 2009

Radiotherapy and Concomitant Intra-Arterial Docetaxel Combined With Systemic 5-Fluorouracil and Cisplatin for Oropharyngeal Cancer: A Preliminary Report—Improvement of Locoregional Control of Oropharyngeal Cancer

  • Hirobumi Oikawa, M.D.

      Affiliations

    • Department of Radiology, Iwate Medical University, Morioka, Japan
    • Corresponding Author InformationReprint requests to: Hirobumi Oikawa, M.D., Department of Radiology, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505 Japan. Tel: (+19) 651-5111; Fax: (+19) 622-1091
    • ,
  • Ryuji Nakamura, M.D.

      Affiliations

    • Department of Radiology, Iwate Medical University, Morioka, Japan
    • ,
  • Tatsuhiko Nakasato, M.D.

      Affiliations

    • Department of Radiology, Iwate Medical University, Morioka, Japan
    • ,
  • Kohji Nishimura, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Iwate Medical University, Morioka, Japan
    • ,
  • Hiroaki Sato, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Iwate Medical University, Morioka, Japan
    • ,
  • Shigeru Ehara, M.D.

      Affiliations

    • Department of Otorhinolaryngology, Iwate Medical University, Morioka, Japan

Received 14 October 2008 ,Revised 16 February 2009 ,Accepted 26 February 2009.

References 

  1. Merlano M, Benasso M, Corvo R, et al. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer Inst. 1996;88:583–589
  2. Marcial VA, Pajak T, Mohiuddin M, et al. Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Cancer. 1990;66:1861–1868
  3. Vokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: Rationale and clinical experience in patients with solid tumors. J Clin Oncol. 1990;8:911–934
  4. Calais G, Alfonsi M, Bardet E, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst. 1999;91:2081–2086
  5. Rabbani A, Hinerman RW, Schmalfuss IM, et al. Radiotherapy and concomitant intraarterial cisplatin (RADPLAT) for advanced squamous cell carcinoma of the head and neck. Am J Clin Oncol. 2007;30:283–286
  6. Robbins KT, Kumar P, Wong FSH, et al. Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients. Head and Neck. 2000;22:687–693
  7. Calais G, Bardet E, Sire C, et al. Radiotherapy with concomitant weekly docetaxel for stage III/IV oropharynx carcinoma: Results of the 98-02 GORTEC phase II trial. Int J Radiat Oncol Biol Phys. 2004;58:161–166
  8. Vermorken JB, Remenar E, Herpen CV, et al. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 2007;357:1695–1704
  9. Posner MR, Glisson B, Frenette G, et al. Multicenter phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck. J Clin Oncol. 2001;19:1096–1104
  10. Haddad R, Tishiler RB, Norris CM, et al. Docetaxel, cisplatin, 5-fluorouracil (TPF)-based induction chemotherapy for head and neck cancer and the case for sequential, combined-modality treatment. Oncologist. 2003;8:35–44
  11. Haddad R, Colevas AD, Tishler R, et al. Docetaxel, cisplatin, and 5-fluorouracil–based induction chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. Cancer. 2003;97:412–418
  12. Akisada T, Harada T, Takemoto T, et al. A case of advanced hypopharyngeal carcinoma successfully treated with superselective intra-arterial infusion of docetaxel. Jpn J Cancer Chemother. 2002;29:323–328
  13. Robbins KT, Doweck I, Samant S, et al. Factors predictive of local disease control after intra-arterial concomitant chemoradiation (RADPLAT). Laryngoscope. 2004;114:411–417
  14. Machtay M, Moughan J, Trotti A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: An RTOG analysis. J Clin Oncol. 2008;26:3582–3589

 Presented at the 5th Japan-U.S. Cancer Therapy Symposium, September 7–9, 2007, Sendai, Japan.

 Conflict of interest: none.

PII: S0360-3016(09)00849-9

doi: 10.1016/j.ijrobp.2009.02.084

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 338-342 , 1 October 2009

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