International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 348-356 , 1 October 2009

Prospective Comparison of Surgery Alone and Chemoradiotherapy With Selective Surgery in Resectable Squamous Cell Carcinoma of the Esophagus

  • Hisanori Ariga, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan
    • Corresponding Author InformationReprint requests to: Hisanori Ariga, M.D., Ph.D., Department of Radiation Oncology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Tel: (+81) 22-717-7312; Fax: (+81) 22-717-7316
    • ,
  • Kenji Nemoto, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan
    • ,
  • Shukichi Miyazaki, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Takashi Yoshioka, M.D., Ph.D.

      Affiliations

    • Department of Clinical Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan
    • ,
  • Yohishiro Ogawa, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Toru Sakayauchi, M.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Keiichi Jingu, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Go Miyata, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Ko Onodera, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Hirofumi Ichikawa, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Takashi Kamei, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Shunsuke Kato, M.D., Ph.D.

      Affiliations

    • Department of Medical Oncology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Chikashi Ishioka, M.D., Ph.D.

      Affiliations

    • Department of Medical Oncology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Susumu Satomi, M.D., Ph.D.

      Affiliations

    • Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Shogo Yamada, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan

Received 21 October 2008 ,Revised 23 December 2008 ,Accepted 5 February 2009.

References 

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  2. Minsky BD, Pajak TF, Ginsberg RJ, et al. INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: High-dose versus standard-dose radiation therapy. J Clin Oncol. 2002;20:1167–1174
  3. Daly JM, Karnell LH, Menck HR. National Cancer Data Base report on esophageal carcinoma. Cancer. 1996;78:1820–1828
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  11. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–376
  12. Wilson KS, Lim JT. Primary chemo-radiotherapy and selective oesophagectomy for oesophageal cancer: Goal of cure with organ preservation. Radiother Oncol. 2000;54:129–134
  13. Coia LR, Minsky BD, Berkey BA, et al. Outcome of patients receiving radiation for cancer of the esophagus: Results of the 1992-1994 Patterns of Care Study. J Clin Oncol. 2000;18:455–462
  14. Liao Z, Zhang Z, Jin J, et al. Esophagectomy after concurrent chemoradiotherapy improves locoregional control in clinical stage II or III esophageal cancer patients. Int J Radiat Oncol Biol Phys. 2004;60:1484–1493
  15. Swisher SG, Wynn P, Putnam JB, et al. Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J Thorac Cardiovasc Surg. 2002;123:175–183
  16. Gardner-Thorpe J, Hardwick RH, Dwerryhouse SJ. Salvage oesophagectomy after local failure of definitive chemoradiotherapy. Br J Surg. 2007;94:1059–1066
  17. Gebski V, Burmeister B, Smithers BM, et al. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol. 2007;8:226–234
  18. Jingu K, Nemoto K, Kaneta T, et al. Temporal change in brain natriuretic Peptide after radiotherapy for thoracic esophageal cancer. Int J Radiat Oncol Biol Phys. 2007;69:1417–1423
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  20. Bonnetain F, Bouche O, Michel P, et al. A comparative longitudinal quality of life study using the Spitzer quality of life index in a randomized multicenter phase III trial (FFCD 9102): Chemoradiation followed by surgery compared with chemoradiation alone in locally advanced squamous resectable thoracic esophageal cancer. Ann Oncol. 2006;17:827–834

 Conflict of interest: none.

PII: S0360-3016(09)00851-7

doi: 10.1016/j.ijrobp.2009.02.086

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 348-356 , 1 October 2009

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