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International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3
, Pages 773-783
, 1 July 2010
Late Gastrointestinal Toxicity After Dose-Escalated Conformal Radiotherapy for Early Prostate Cancer: Results From the UK Medical Research Council RT01 Trial (ISRCTN47772397)
References
- Long-term results of the M.D. Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:67–74
- Dose response in radiotherapy for localized prostate cancer: Results of the Dutch multicenter phase III randomized trial comparing 68 Gy with 78 Gy. J Clin Oncol. 2006;24:1990–1906
- Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:980–988
- Comparison of conventional-dose versus high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate. JAMA. 2005;294:1233–1239
- Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects. Br J Cancer. 2005;92:488–498
- The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localized prostate cancer: Results from the MRC RT01 trial (ISRCTN47772397). Radiother Oncol. 2007;83:31–41
- Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomised controlled trial. Lancet Oncol. 2007;8:475–487
- Implementing the UK Medical Research Council (MRC) RT01 trial (ISRCTN 47772397): Methods and practicalities of a randomised controlled trial of conformal radiotherapy in men with localised prostate cancer. Radiother Oncol. 2004;72:199–211
- . Long-term survival rates of patients with prostate cancer in the prostate-specific antigen screening era: Population-based estimates for the year 2000 by period analysis. J Clin Oncol. 2005;23:441–447
- Correlation of radiotherapeutic parameters and treatment related morbidity–analysis of RTOG Study 77-06. Int J Radiat Oncol Biol Phys. 1987;13:1007–1012
- LENT SOMA tables. Radiother Oncol. 1995;35:17–60
- The UCLA prostate cancer index: Development, reliability, and validity of a health-related quality of life measure. Med Care. 1998;36:1002–1012
- Measuring quality of life in men with prostate cancer using the functional assessment of cancer therapy-prostate instrument. Urology. 1997;50:920–928
- Impact of volume and location of the irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 2004;58:1072–1082
- Toxicity after three–dimensional radiotherapy for prostate cancer on RTOG 9406 dose level V. Int J Radiat Oncol Biol Phys. 2005;62:706–713
- Late rectal symptoms and quality of life after conformal radiation therapy for prostate cancer. Radiother Oncol. 2006;79:341–347
- Proposed rectal dose constraints for patients undergoing definite whole pelvic radiotherapy for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:69–77
- Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005;61:1011–1018
- Increased risk of biochemical and local failure in patients with distended rectum on the CT planning for prostate radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:965–973
- Increased risk of biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning: Results from the Dutch trial of 68 Gy versus 78 Gy. Int J Radiat Oncol Biol Phys. 2007;67:1418–1423
- Patient-assessed late toxicity rates and principal component analysis after image-guided radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2007;68:690–698
- Grading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:1138–1145
- . Gastrointestinal symptoms after pelvic radiotherapy: Role for the gastroenterologist. Int J Radiat Oncol Biol Phys. 2005;62:1464–1471
- . Patient and physician reporting of symptoms and health-related quality of life in trials of treatment for early prostate cancer: Consideration for future studies. Clin Oncol. 2006;18:735–743
- Chronic rectal bleeding after high-dose conformal treatment of prostate cancer warrants modification of existing morbidity scales. Int J Radiat Oncol Biol Phys. 1997;38:59–63
- Scoring of treatment-related late effects in prostate cancer. Radiother Oncol. 2002;65:109–121
- Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358:1250–1261
- Offering a treatment choice in the irradiation of prostate cancer leads to better informed and more active patients, without harm to well-being. Int J Radiat Oncol Biol Phys. 2008;70:42–48
- A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy. Int J Radiat Oncol Biol Phys. 2008;71:41–50
- Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: Evidence from the MRC RT01 trial ISRCTN 47772397. Int J Radiat Oncol Biol Phys. 2009;In press
- Intensity-modulated radiotherapy as primary therapy for prostate cancer: report on acute toxicity after dose escalation with simultaneous integrated boost to intraprostatic lesion. Int J Radiat Oncol Biol Phys. 2008;72:799–807
This trial was supported by the Medical Research Council, London, UK.
Conflicts of interest: none.
PII: S0360-3016(09)00874-8
doi: 10.1016/j.ijrobp.2009.05.052
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International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3
, Pages 773-783
, 1 July 2010
