International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 4 , Pages 1012-1017 , 15 March 2010

Sexual Function in Males After Radiotherapy for Rectal Cancer

  • Kjersti Bruheim, M.D.

      Affiliations

    • Oslo University Hospital, Ullevål Cancer Centre, Oslo, Norway
    • Corresponding Author InformationReprint requests to: Kjersti Bruheim, MD, Oslo University Hospital, Ullevål Cancer Centre, 0407 Oslo, Norway. Tel: (+47) 23-02-66-00; Fax: (+47) 23-02-66-01
    • ,
  • Marianne G. Guren, M.D., Ph.D.

      Affiliations

    • Oslo University Hospital, Ullevål Cancer Centre, Oslo, Norway
    • ,
  • Alv A. Dahl, M.D., Ph.D.

      Affiliations

    • Oslo University Hospital, Department of Clinical Cancer Research, the Norwegian Radium Hospital, Oslo, Norway
    • Faculty of Medicine, University of Oslo, Oslo, Norway
    • ,
  • Eva Skovlund, Ph.D.

      Affiliations

    • School of Pharmacy, University of Oslo, Oslo, Norway
    • ,
  • Lise Balteskard, M.D., Ph.D.

      Affiliations

    • The University Hospital of Northern Norway, Tromsø, Norway
    • ,
  • Erik Carlsen, M.D., Ph.D.

      Affiliations

    • Oslo University Hospital, Department of Gastrointestinal Surgery, Ullevål, Oslo, Norway
    • ,
  • Sophie D. Fosså, M.D., Ph.D.

      Affiliations

    • Oslo University Hospital, Department of Clinical Cancer Research, the Norwegian Radium Hospital, Oslo, Norway
    • Faculty of Medicine, University of Oslo, Oslo, Norway
    • ,
  • Kjell Magne Tveit, M.D., Ph.D.

      Affiliations

    • Oslo University Hospital, Ullevål Cancer Centre, Oslo, Norway
    • Faculty of Medicine, University of Oslo, Oslo, Norway

Received 11 March 2009 ,Revised 11 March 2009 ,Accepted 12 March 2009.

References 

  1. Nesbakken A, Nygaard K, Bull-Njaa T, et al. Bladder and sexual dysfunction after mesorectal excision for rectal cancer. Br J Surg. 2000;87:206–210
  2. Maurer CA. Urinary and sexual function after total mesorectal excision. Recent Results Cancer Res. 2005;165:196–204
  3. Hendren SK, O'Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg. 2005;242:212–223
  4. Kim NK, Aahn TW, Park JK, et al. Assessment of sexual and voiding function after total mesorectal excision with pelvic autonomic nerve preservation in males with rectal cancer. Dis Colon Rectum. 2002;45:1178–1185
  5. Pinkawa M, Gagel B, Piroth MD, et al. Erectile dysfunction after external beam radiotherapy for prostate cancer. Eur Urol. 2009;55:227–236
  6. Mulhall J, Ahmed A, Parker M, et al. The hemodynamics of erectile dysfunction following external beam radiation for prostate cancer. J Sex Med. 2005;2:432–437
  7. Birgisson H, Pahlman L, Gunnarsson U, et al. Late adverse effects of radiation therapy for rectal cancer—a systematic overview. Acta Oncol. 2007;46:504–516
  8. Marijnen CA, van de Velde CJH, Putter H, et al. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol. 2005;23:1847–1858
  9. Heriot AG, Tekkis PP, Fazio VW, et al. Adjuvant radiotherapy is associated with increased sexual dysfunction in male patients undergoing resection for rectal cancer: A predictive model. Ann Surg. 2005;242:502–510
  10. Bonnel C, Parc YR, Pocard M, et al. Effects of preoperative radiotherapy for primary resectable rectal adenocarcinoma on male sexual and urinary function. Dis Colon Rectum. 2002;45:934–939
  11. Bruheim K, Svartberg J, Carlsen E, et al. Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH. Int J Radiat Oncol Biol Phys. 2008;70:722–727
  12. Rosen RC, Riley A, Wagner G, et al. The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822–830
  13. MAPI Research Trust. Available at: http://www.mapi-trust.org. 2009.
  14. Cappelleri JC, Rosen RC, Smith MD, et al. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology. 1999;54:346–351
  15. Cappelleri JC, Siegel RL, Osterloh IH, et al. Relationship between patient self-assessment of erectile function and the erectile function domain of the international index of erectile function. Urology. 2000;56:477–481
  16. Tveit KM, Guldvog I, Hagen S, et al. Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Norwegian Adjuvant Rectal Cancer Project Group. Br J Surg. 1997;84:1130–1135
  17. Braendengen M, Tveit KM, Berglund A, et al. Randomized Phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol. 2008;26:3687–3694
  18. Kline RB. Principles and practice of structural equation modelling. New York: Guilford Press; 2005;
  19. van der Wielen GJ, Hoogeman MS, Dohle GR, et al. Dose–volume parameters of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy for prostate cancer: Results from a dose-escalation trial. Int J Radiat Oncol Biol Phys. 2008;71:795–800
  20. Yassin AA, Saad F. Testosterone and erectile dysfunction. J Androl. 2008;29:593–604
  21. Morales A, Buvat J, Gooren LJ, et al. Endocrine aspects of sexual dysfunction in men. J Sex Med. 2004;1:69–81
  22. Yoon FH, Perera F, Fisher B, et al. Alterations in hormone levels after adjuvant chemoradiation in male rectal cancer patients. Int J Radiat Oncol Biol Phys. 2009;74:1186–1190

 This work was supported by a research grant from the South Eastern Norway Health Authority and with support from the Norwegian Colorectal Registry and the Norwegian Cancer Registry.

 Conflicts of interest: none.

PII: S0360-3016(09)00909-2

doi: 10.1016/j.ijrobp.2009.03.075

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 4 , Pages 1012-1017 , 15 March 2010

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