International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 743-750 , 1 July 2010

Patterns of Radiotherapy Practice for Pancreatic Cancer in Japan: Results of the Japanese Radiation Oncology Study Group (JROSG) Survey

  • Kazuhiko Ogawa, M.D.

      Affiliations

    • Department of Radiology, University of the Ryukyus, Okinawa, Japan
    • Corresponding Author InformationReprint requests to: Kazuhiko Ogawa, M.D., Department of Radiology, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215 Japan. Tel: (81) 98-895-3331, ext. 2401; Fax: (81) 98-895-1420
  • ,
  • Yoshinori Ito, M.D.

      Affiliations

    • Department of Radiation Oncology, National Cancer Center, Tokyo, Japan
  • ,
  • Katsuyuki Karasawa, M.D.

      Affiliations

    • Department of Radiation Oncology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
  • ,
  • Yoshihiro Ogawa, M.D.

      Affiliations

    • Department of Radiation Oncology, Tohoku University, Sendai, Japan
  • ,
  • Hiroshi Onishi, M.D.

      Affiliations

    • Department of Radiology, Yamanashi University, Yamanashi, Japan
  • ,
  • Tomoko Kazumoto, M.D.

      Affiliations

    • Department of Radiation Oncology, Saitama Cancer Center, Saitama, Japan
  • ,
  • Keiko Shibuya, M.D.

      Affiliations

    • Department of Radiation Oncology and Image-Applied Therapy, Kyoto University, Kyoto, Japan
  • ,
  • Hitoshi Shibuya, M.D.

      Affiliations

    • Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan
  • ,
  • Yoshishige Okuno, M.D.

      Affiliations

    • Department of Radiation Oncology, Kobe City Medical Center General Hospital, Kobe, Japan
  • ,
  • Shigeo Nishino, M.D.

      Affiliations

    • Department of Radiation Oncology, Sapporo Kosei General Hospital, Sapporo, Japan
  • ,
  • Etsuyo Ogo, M.D.

      Affiliations

    • Department of Radiology, Kurume University, Kurume, Japan
  • ,
  • Nobue Uchida, M.D.

      Affiliations

    • Department of Radiation Oncology, Shimane Medical University, Shimane, Japan
  • ,
  • Kumiko Karasawa, M.D.

      Affiliations

    • Department of Radiation Oncology, Juntendo University, Tokyo, Japan
  • ,
  • Kenji Nemoto, M.D.

      Affiliations

    • Department of Radiation Oncology, Yamagata University, Yamagata, Japan
  • ,
  • Yasumasa Nishimura, M.D.

      Affiliations

    • Department of Radiation Oncology, Kinki University School of Medicine, Osaka, Japan
  • ,
  • JROSG Working Subgroup of Gastrointestinal Cancers

Received 13 April 2009 ,Revised 22 May 2009 ,Accepted 22 May 2009.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
  2. Gudjonsson B. Cancer of the pancreas: 50 Years of surgery. Cancer. 1987;60:2284–2303
  3. Hawes RH, Xiong Q, Waxman I, et al. A multispecialty approach to the diagnosis and management of pancreatic cancer. Am J Gastroenterol. 2000;95:17–31
  4. Willett CG, Czito BG, Bendell JC, et al. Locally advanced pancreatic cancer. J Clin Oncol. 2005;23:4538–4544
  5. National Cancer Center. National Cancer Center Cancer information service. Available from: http://www.ncc.go.jp/. Accessed July 9, 2009.
  6. Shibuya H, Tsujii H. The structural characteristics of radiation oncology in Japan in 2003. Int J Radiat Oncol Biol Phys. 2005;62:1472–1476
  7. Teshima T, Numasaki H, Shibuya H, et al. Japanese structure survey of radiation oncology in 2005 based on institutional stratification of patterns of care study. Int J Radiat Oncol Biol Phys. 2008;72:144–152
  8. Hanks GE, Coia LR, Curry J. Patterns of care studies: past, present and future. Semin Radiat Oncol. 1997;7:97–100
  9. Owen JB, Sedransk J, Pajak TF. National averages for process and outcome in radiation oncology: Methodology of the patterns of care study. Semin Radiat Oncol. 1997;7:101–107
  10. Teshima T. Patterns of care study in Japan. Jpn J Clin Oncol. 2005;35:497–506
  11. Ogawa K, Nakamura K, Onishi H, et al. Radical external beam radiotherapy for clinically localized prostate cancer in Japan: Changing trends in the patterns of care process survey between 1996–1998 and 1999–2001. Anticancer Res. 2005;25:3507–3511
  12. Mitsumori M, Hiraoka M, Negoro Y, et al. The patterns of care study for breast-conserving therapy in Japan: Analysis of process survey from 1995 to 1997. Int J Radiat Oncol Biol Phys. 2005;62:1048–1054
  13. Uno T, Sumi M, Ishihara Y, et al. Changes in patterns of care for limited-stage small-cell lung cancer: Results of the 99-01 patterns of care study—A nationwide survey in Japan. Int J Radiat Oncol Biol Phys. 2008;71:414–419
  14. Goonetilleke KS, Siriwardena AK. Nationwide questionnaire survey of the contemporary surgical management of pancreatic cancer in the United Kingdom & Ireland. Int J Surg. 2007;5:147–151
  15. Makowiec F, Post S, Saeger HD, et al. Current practice patterns in pancreatic surgery: Results of a multi-institutional analysis of seven large surgical departments in Germany with 1454 pancreatic head resections, 1999 to 2004 (German Advanced Surgical Treatment study group). J Gastrointest Surg. 2005;9:1080–1086
  16. Niederhuber JE, Brennan MF, Menck HR. The National Cancer Data Base report on pancreatic cancer. Cancer. 1995;76:1671–1677
  17. Bilimoria KY, Bentrem DJ, Ko CY, et al. Multimodality therapy for pancreatic cancer in the U.S.: Utilization, outcomes, and the effect of hospital volume. Cancer. 2007;110:1227–1234
  18. Stessin AM, Meyer JE, Sherr DL. Neoadjuvant radiation is associated with improved survival in patients with resectable pancreatic cancer: An analysis of data from the Surveillance, Epidemiology, and End Results (SEER) registry. Int J Radiat Oncol Biol Phys. 2008;72:1128–1133
  19. Artinyan A, Hellan M, Mojica-Manosa P, et al. Improved survival with adjuvant external-beam radiation therapy in lymph node-negative pancreatic cancer: A United States population-based assessment. Cancer. 2008;112:34–42
  20. Hazard L, Tward JD, Szabo A, et al. Radiation therapy is associated with improved survival in patients with pancreatic adenocarcinoma: Results of a study from the Surveillance, Epidemiology, and End Results (SEER) registry data. Cancer. 2007;110:2191–2201
  21. Li D, Xie K, Wolff R, et al. Pancreatic cancer. Lancet. 2004;363:1049–1057
  22. DiMagno EP, Reber HA, Tempero MA American Gastroenterological Association. AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterology. 1999;117:1464–1484
  23. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology™: Pancratic adenocarcinoma. V.I. 2008. Available from: http://www.nccn.org/. Accessed July 9, 2009.
  24. Ruano-Ravina A, Almazán Ortega R, Guedea F. Intraoperative radiotherapy in pancreatic cancer: A systematic review. Radiother Oncol. 2008;87:318–325
  25. Hiraoka T, Uchino R, Kanemitsu K, et al. Combination of intraoperative radiation with resection of cancer of the pancreas. Int J Pancreatol. 1990;7:201–207
  26. Roldan GE, Gunderson LL, Nagorney DM, et al. External beam versus intraoperative and external beam irradiation for locally advanced pancreatic cancer. Cancer. 1988;61:1110–1116
  27. Crane CH, Abbruzzese JL, Evans DB, et al. Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil–based chemoradiation in locally advanced pancreatic cancer?. Int J Radiat Oncol Biol Phys. 2002;52:1293–1302
  28. Moertel CG, Reitemeier RJ, Hahn RG. Mitomycin C therapy in advanced gastrointestinal cancer. JAMA. 1968;204:1045–1048
  29. Buroker T, Kim PN, Groppe C, et al. 5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: A Southwest Oncology Group Study. Cancer. 1979;44:1215–1221
  30. Burris HA, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol. 1997;15:2403–2413
  31. Klaassen DJ, MacIntyre JM, Catton GE, et al. Treatment of locally unresectable cancer of the stomach and pancreas: A randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil—An Eastern Cooperative Oncology Group study. J Clin Oncol. 1985;3:373–378
  32. André T, Balosso J, Louvet C, et al. Combined radiotherapy and chemotherapy (cisplatin and 5-fluorouracil) as palliative treatment for localized unresectable or adjuvant treatment for resected pancreatic adenocarcinoma: Results of a feasibility study. Int J Radiat Oncol Biol Phys. 2000;46:903–911
  33. Ishii H, Okada S, Tokuuye K, et al. Protracted 5-fluorouracil infusion with concurrent radiotherapy as a treatment for locally advanced pancreatic carcinoma. Cancer. 1997;79:1516–1520
  34. Sultana A, Tudur Smith C, Cunningham D, et al. Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br J Cancer. 2007;96:1183–1190
  35. Huguet F, André T, Hammel P, et al. Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase II and III studies. J Clin Oncol. 2007;25:326–331
  36. Krishnan S, Rana V, Janjan NA, et al. Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy. Cancer. 2007;110:47–55

 Conflict of interest: none.

PII: S0360-3016(09)00926-2

doi: 10.1016/j.ijrobp.2009.05.063

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 743-750 , 1 July 2010