International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 323-325 , 1 October 2009

Don't Squeeze Hypofractionated Schedules into Too-Short Overall Times

  • Jack Fowler, Ph.D., D.Sc.

      Affiliations

    • Departments of Human Oncology and Medical Physics, University of Wisconsin Medical School, Madison, WI
    • Corresponding Author InformationReprint requests to: Jack F. Fowler, Ph.D., Flat 1, 150 Lambeth Road, London SE1 7DF, United Kingdom. Tel: (+44) 207-207-7997
    • ,
  • Christopher R. King, Ph.D., M.D.

      Affiliations

    • Department of Radiation Oncology, Stanford University School of Medicine, Stanford Medical Center, Stanford, CA

Received 29 April 2009 ,Revised 4 June 2009 ,Accepted 5 June 2009.

References 

  1. Fowler JF, Harari PM, Leborgne F, Leborgne JH. Acute radiation reactions in oral and pharyngeal mucosa: Tolerable levels in altered fractionation schedules. Radiother Oncol. 2003;69:161–168
  2. Steel GG. Basic clinical radiobiology. 3rd ed. London: Arnold; 2002;p. 25, 31, 108
  3. Bentzen SM, Saunders MI, Dische S, et al. Radiotherapy-related early morbidity in head and neck cancer: Quantitative clinical radiobiology as deduced from the CHART trial. Radiother Oncol. 2001;60:123–135
  4. Dörr W, Hamilton CS, Boyd T, et al. Radiation-induced changes in cellularity and proliferation in human oral mucosa. Int J Radiat Oncol Biol Phys. 2002;52:911–917
  5. Withers HR, Taylor JM, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27:131–146
  6. Perez CA, Michalski J, Mansur D, et al. Impact of elapsed treatment time on outcome of external-beam radiation therapy for localized carcinoma of the prostate. Cancer J. 2004;10:349–356
  7. Fowler JF. Practical time-dose evaluation, or how to stop worrying and love LQ. In:  Levitt SH,  Purdy JA,  Perez CA, et al. editor. Technical basis of radiation therapy. 4th revised ed. Heidelberg: Springer-Verlag; 2006;p. 3–31
  8. Huang EH, Pollack A, Levy L, et al. Late rectal toxicity: dose-volume effects of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2002;54:1314–1321
  9. Vargas C, Martinez A, Kestin LL, et al. Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:1297–1308
  10. Peeters STH, Heemsbergen WD, van Putten WLJ, et al. Acute and late complications after radiotherapy for prostate cancer: Results of a multicenter randomized trial comparing 68 Gy to 78 Gy. Int J Radiat Oncol Biol Phys. 2005;61:1019–1034
  11. Martin JM, Bayley A, Catton CN, et al. A prospective study of hypofractionated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2006;66:S35–S36
  12. Dearnaley D, Norman A, Syndikus I, et al. Conventional vs hypofractionated high dose intensity modulated radiotherapy for prostate cancer (CHHIP)—a phase III multicentre trial. Preliminary report on acute and late toxicity (ISRCTNN 97182923) (Abstr.). Presented at the 2007 American Society of Clinical Oncology Prostate Cancer Symposium, February 22–24, 2007, Orlando, Florida.
  13. Arcangeli S, Strigari L, Soete G, et al. Clinical and dosimetric predictors of acute toxicity after a 4-week hypofractionated external beam radiotherapy regimen for prostate cancer: Results from a multicentric prospective trial. Int J Radiat Oncol Biol Phys. 2009;73:39–45
  14. Leborgne F, Fowler JF. Acute toxicity after hypofractionated conformal radiotherapy for localized prostate cancer: Nonrandomized contemporary comparison with standard fractionation. Int J Radiat Oncol Biol Phys. 2008;72:770–776
  15. King CR, Brooks JD, Gill H, et al. Stereotactic body radiotherapy for localized prostate cancer: Interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys. 2009;73:1043–1048

 Conflict of interest: none.

PII: S0360-3016(09)00930-4

doi: 10.1016/j.ijrobp.2009.06.022

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 2 , Pages 323-325 , 1 October 2009

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