International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 677-684 , 1 July 2010

Effect of Radiotherapy Dose and Volume on Relapse in Merkel Cell Cancer of the Skin

  • Matthew Foote, M.B. B.S.

      Affiliations

    • Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    • Corresponding Author InformationReprint requests to: Matthew Foote, M.B. B.S., Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia. Tel: (+61) 448-948-246; Fax: (+61) 7-3240-6127
    • ,
  • Jennifer Harvey, F.R.A.N.Z.C.R.

      Affiliations

    • Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    • ,
  • Sandro Porceddu, F.R.A.N.Z.C.R.

      Affiliations

    • Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    • ,
  • Graeme Dickie, F.R.A.N.Z.C.R.

      Affiliations

    • Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
    • ,
  • Susan Hewitt, F.R.A.N.Z.C.R.

      Affiliations

    • Division of Cancer, Townsville Hospital, Townsville, Queensland, Australia
    • ,
  • Shoni Colquist, B.Sc.

      Affiliations

    • Queensland Cancer Control Analysis Team, Queensland Health, Brisbane, Queensland, Australia
    • ,
  • Dannie Zarate, Ph.D.

      Affiliations

    • Queensland Cancer Control Analysis Team, Queensland Health, Brisbane, Queensland, Australia
    • ,
  • Michael Poulsen, F.R.A.N.Z.C.R.

      Affiliations

    • Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia

Received 14 March 2009 ,Revised 28 May 2009 ,Accepted 29 May 2009.

References 

  1. Goessling W, McKee PH, Mayer RJ. Merkel cell carcinoma. J Clin Oncol. 2002;20:588–598
  2. Tai PT, Yu E, Winquist E, et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin. Case series and review of 204 cases. J Clin Oncol. 2000;18:2493–2499
  3. Gillenwater AM, Hessel AC, Morrison WH, et al. Merkel cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2001;127:149–154
  4. Henness S, Vereecken P. Management of Merkel tumours: An evidence-based review. Curr Opin Oncol. 2008;20:280–286
  5. Poulsen M. Merkel cell carcinoma of the skin. Lancet Oncol. 2004;5:593–599
  6. Koljonen V. Merkel cell carcinoma. World J Surg Oncol. 2006;24:7–18
  7. Leonard JH, Ramsay JR, Kearsley JH, et al. Radiation sensitivity of Merkel cell carcinoma cell lines. Int J Radiat Oncol Biol Phys. 1995;32:1401–1407
  8. Meeuwissen JA, Bourne RG, Kearsley JH. The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys. 1995;31:323–331
  9. Wong KC, Zuletta F, Clarke SJ, et al. Clinical management and treatment outcomes of Merkel cell carcinoma. A N Z J Surg. 1998;68:354–358
  10. Veness M. Improved outcome with the addition of adjuvant therapy. J Clin Oncol. 2005;25:7235–7237
  11. Decker RH, Wilson LD. Role of RT in the management of Merkel cell carcinoma. J Natl Compr Canc Netw. 2006;4:713–718
  12. Mojica P, Smith D, Ellenhorn J. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Oncol. 2007;25:1043–1047
  13. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: Prognosis and treatment from a single institution. J Clin Oncol. 2005;23:2300–2309
  14. Poulsen M, Rischin D, Walpole E, et al. High risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: A Trans-Tasman Radiation Oncology Group Study, TROG 96:07. J Clin Oncol. 2003;21:4371–4376
  15. Allen PJ, Zhang ZF, Coit DG. Surgical management of Merkel cell carcinoma. Ann Surg. 1999;229:97–105
  16. Boyer JD, Zitelli JA, Brodland DG, et al. Local control of primary Merkel cell carcinoma: Review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol. 2002;47:885–892
  17. Eich HT, Eich D, Staar S, et al. Role of postoperative radiotherapy in the management of Merkel cell carcinoma. Am J Clin Oncol. 2002;25:50–56
  18. Muller A, Keus R, Neumann N, et al. Management of Merkel cell carcinoma: Case series of 36 patients. Oncol Rep. 2003;10:577–585
  19. Senchenkov A, Barnes SA, Moran SL. Predictors of survival and recurrence in the surgical treatment of Merkel cell carcinoma of the extremities. J Surg Oncol. 2007;95:229–234
  20. Veness MJ, Perera L, McCourt J, et al. Merkel cell carcinoma: Improved outcome with adjuvant radiotherapy. A N Z J Surg. 2005;75:275–281
  21. Veness MJ, Morgan GJ, Gebski V. Adjuvant locoregional radiotherapy as best practice in patients with Merkel cell carcinoma of the head and neck. Head Neck. 2005;27:208–216
  22. Gupta SG, Wang LC, Peñas PF, et al. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature. Arch Dermatol. 2006;142:685–690
  23. Withers HR, Thames HD, Peters LJ. A new isoeffect curve for change in dose per fraction. Radiother Oncol. 1983;1:187–191

 Conflict of interest: none.

PII: S0360-3016(09)00937-7

doi: 10.1016/j.ijrobp.2009.05.067

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 677-684 , 1 July 2010

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