International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 4 , Pages 1046-1052 , 15 July 2010

Radiation With or Without 6 Months of Androgen Suppression Therapy in Intermediate- and High-Risk Clinically Localized Prostate Cancer: A Postrandomization Analysis by Risk Group

This work was presented in part at the 45th meeting of the American Society of Clinical Oncology, Orlando FL, May 29 - June 2, 2009.

  • Paul L. Nguyen, M.D.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests to: Paul L. Nguyen, M.D., Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115. Tel: (617) 732-6310; Fax: (617) 732-7347
    • ,
  • Ming-Hui Chen, Ph.D.

      Affiliations

    • Department of Statistics, University of Connecticut, Storrs, Connecticut
    • ,
  • Clair J. Beard, M.D.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • W. Warren Suh, M.D., M.P.H.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Andrew A. Renshaw, M.D.

      Affiliations

    • Department of Pathology, Baptist Hospital of Miami, Miami, Florida
    • ,
  • Marian Loffredo, R.N., B.S., O.C.N.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • ,
  • Elizabeth McMahon, R.N., B.S.N.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • ,
  • Philip W. Kantoff, M.D.

      Affiliations

    • Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts
    • ,
  • Anthony V. D'Amico, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts
    • Harvard Medical School, Boston, Massachusetts

Received 22 March 2009 ,Revised 3 June 2009 ,Accepted 4 June 2009.

References 

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  2. D'Amico AV, Chen MH, Renshaw AA, et al. Androgen suppression and radiation vs. radiation alone for prostate cancer: a randomized trial. JAMA. 2008;299:289–295
  3. Tsai HK, D'Amico AV, Sadetsky N, et al. Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality. J Natl Cancer Inst. 2007;99:1516–1524
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  12. Zietman AL. Correction: inaccurate analysis and results in a study of radiation therapy in adenocarcinoma of the prostate. JAMA. 2008;299:898–899
  13. Zietman AL, DeSilvio ML, Slater JD, et al. Comparison of conventional-dose vs. high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial. JAMA. 2005;294:1233–1239
  14. Liauw SL, Fricano J, Correa D, et al. Dose-escalated radiation therapy for intermediate-risk prostate cancer: Patient selection for androgen deprivation therapy using percentage of positive cores. Cancer. 2009;115:1784–1790
  15. Denham JW, Steigler A, Lamb DS, et al. Short-term androgen deprivation and radiotherapy for locally advanced prostate cancer: results from the Trans-Tasman Radiation Oncology Group 96.01 randomised controlled trial. Lancet Oncol. 2005;6:841–850
  16. Efstathiou JA, Bae K, Shipley WU, et al. Cardiovascular mortality after androgen deprivation therapy for locally advanced prostate cancer: RTOG 85-31. J Clin Oncol. 2009;27:92–99
  17. Roach M,, Bae K, Speight J, et al. Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: Long-term results of RTOG 8610. J Clin Oncol. 2008;26:585–591
  18. D'Amico AV, Chen MH, Renshaw AA, et al. Causes of death in men undergoing androgen suppression therapy for newly diagnosed localized or recurrent prostate cancer. Cancer. 2008;113:3290–3297

 Conflict of interest: none.

PII: S0360-3016(09)00951-1

doi: 10.1016/j.ijrobp.2009.06.038

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 4 , Pages 1046-1052 , 15 July 2010

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