International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 1 , Pages 19-25 , 1 September 2010

Urinary Obstruction in Prostate Cancer Patients From the Dutch Trial (68 Gy vs. 78 Gy): Relationships With Local Dose, Acute Effects, and Baseline Characteristics

  • Wilma D. Heemsbergen, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Wilma D. Heemsbergen, Ph.D., Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam 1066 CX The Netherlands. Tel: (+31) 20-512-2144; Fax: (+31) 20-669-1101
  • ,
  • Abrahim Al-Mamgani, M.D.

      Affiliations

    • Department of Radiation Oncology, Erasmus Medical Center–Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
  • ,
  • Marnix G. Witte, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • ,
  • Marcel van Herk, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • ,
  • Floris J. Pos, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
  • ,
  • Joos V. Lebesque, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Received 27 April 2009 ,Revised 3 July 2009 ,Accepted 19 July 2009.

References 

  1. Al-Mamgani A, van Putten WL, Heemsbergen WD, et al. Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;72:980–988
  2. Elliott SP, Meng MV, Elkin EP, et al. Incidence of urethral stricture after primary treatment for prostate cancer: Data from CaPSURE. J Urol. 2007;178:529–534
  3. Harsolia A, Vargas C, Yan D, et al. Predictors for chronic urinary toxicity after the treatment of prostate cancer with adaptive 3D conformal RT: Dose–volume analysis of a Phase III dose-escalation study. Int J Radiat Oncol Biol Phys. 2007;69:1100–1109
  4. Peeters STH, Heemsbergen WD, van Putten WL, et al. Acute and late complications after radiotherapy for prostate cancer: Results of a multi-center randomized trial comparing 68 Gy with 78 Gy. Int J Radiat Oncol Biol Phys. 2005;61:1019–1043
  5. Sandhu AS, Zelefsky MJ, Lee HJ, et al. Long-term urinary toxicity after 3D CRT for prostate cancer in patients with prior history of TURP. Int J Radiat Oncol Biol Phys. 2000;48:643–647
  6. Zelefsky MJ, Cowen D, Fuks Z, et al. Long term tolerance of high dose 3D-CRT in patients with localized prostate carcinoma. Cancer. 1999;85:2460–2468
  7. Karlssdottir A, Muren LP, Wentzel-Larsen T, et al. Late GI morbidity after 3D-CRT for prostate cancer fades with time in contrast to GU morbidity. Int J Radiat Oncol Biol Phys. 2008;70:1478–1486
  8. Hoogeman MS, Peeters STH, De Bois J, et al. Absolute and relative dose-surface and dose-volume histograms of the bladder; which one is the most invariant under bladder filling changes?. Phys Med Biol. 2005;50:3589–3597
  9. Cheung MR, Tucker SL, Dong L, et al. Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2007;67:1059–1065
  10. Dearnaley DP, Sydes MR, Graham JD, et al. Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomized controlled trial. Lancet Oncol. 2007;8:475–487
  11. Kuban DA, Tucker SL, Dong L, et al. Long-term results of the MD Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:67–74
  12. Michalski JM, Winter K, Purdy JA, et al. Toxicity after 3D radiotherapy for prostate cancer on RTOG 9406 dose level V. Int J Radiat Oncol Biol Phys. 2005;62:706–713

 Supported by the Dutch Cancer Society (NKB Grants NKI 98-1830, NKI 2007-3895, and CKTO 96-10).

 Conflict of interest: none.

PII: S0360-3016(09)02785-0

doi: 10.1016/j.ijrobp.2009.07.1680

International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 1 , Pages 19-25 , 1 September 2010