International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 4 , Pages 961-965 , 15 November 2009

American College of Radiology Appropriateness Criteria on Multiple Brain Metastases

  • Expert Panel on Radiation Oncology–Brain Metastases
    • ,
  • Gregory M.M. Videtic, M.D.

      Affiliations

    • Cleveland Clinic Foundation, Cleveland, OH
    • Corresponding Author InformationReprint requests to: Gregory M. M. Videtic, M.D., Department of Radiation Oncology T28, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195-0002. Tel: (216) 444-9797; Fax: (216) 445-1068
    • ,
  • Laurie E. Gaspar, M.D., M.B.A.

      Affiliations

    • University of Colorado Denver, Aurora, CO
    • ,
  • Amr M. Aref, M.D.

      Affiliations

    • Van Elslander Cancer Center, Grosse Point, MI
    • ,
  • Isabelle M. Germano, M.D.

      Affiliations

    • Mount Sinai School of Medicine, New York, NY
    • ,
  • Brian J. Goldsmith, M.D.

      Affiliations

    • Radiological Associates of Sacramento, Sacramento, CA
    • ,
  • Joseph P. Imperato, M.D.

      Affiliations

    • Lake Forest Hospital, Lake Forest, IL
    • ,
  • Karen J. Marcus, M.D.

      Affiliations

    • Children's Hospital/Dana Farber Cancer Center, Harvard Medical School, Boston, MA
    • ,
  • Michael W. McDermott, M.D.

      Affiliations

    • University of California-San Francisco, San Francisco, CA
    • ,
  • Mark W. McDonald, M.D.

      Affiliations

    • Emory University, Atlanta, GA
    • ,
  • Roy A. Patchell, M.D.

      Affiliations

    • Barrow Neurological Institute, Phoenix, AZ
    • ,
  • H. Ian Robins, M.D., Ph.D.

      Affiliations

    • University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center, Madison, WI
    • ,
  • C. Leland Rogers, M.D.

      Affiliations

    • GammaWest Brachytherapy, Salt Lake City, UT
    • ,
  • John H. Suh, M.D.

      Affiliations

    • Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Aaron H. Wolfson, M.D.

      Affiliations

    • University of Miami Miller School of Medicine, Miami, FL
    • ,
  • Franz J. Wippold II, M.D.

      Affiliations

    • Washington University School of Medicine, Saint Louis, MO

Received 28 May 2009 ,Revised 28 July 2009 ,Accepted 30 July 2009.

References 

  1. Posner JB. Management of brain metastases. Rev Neurol (Paris). 1992;148:477–487
  2. Nussbaum ES, Djalilian HR, Cho KH, et al. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer. 1996;78:1781–1788
  3. Delattre JY, Krol G, Thaler HT, et al. Distribution of brain metastases. Arch Neurol. 1988;45:741–744
  4. Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol. 1978;19:579–592
  5. Lee DH, Han JY, Kim HT, et al. Primary chemotherapy for newly diagnosed nonsmall cell lung cancer patients with synchronous brain metastases compared with whole-brain radiotherapy administered first: Result of a randomized pilot study. Cancer. 2008;113:143–149
  6. Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37:745–751
  7. Sperduto PW, Berkey B, Gaspar LE, et al. A new prognostic index and comparison to three other indices for patients with brain metastases: An analysis of 1,960 patients in the RTOG database. Int J Radiat Oncol Biol Phys. 2008;70:510–514
  8. Nieder C, Berberich W, Schnabel K. Tumor-related prognostic factors for remission of brain metastases after radiotherapy. Int J Radiat Oncol Biol Phys. 1997;39:25–30
  9. Swift PS, Phillips T, Martz K, et al. CT characteristics of patients with brain metastases treated in RTOG study 79-16. Int J Radiat Oncol Biol Phys. 1993;25:209–214
  10. Borgelt B, Gelber R, Larson M, et al. Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1981;7:1633–1638
  11. Chatani M, Matayoshi Y, Masaki N, et al. Radiation therapy for brain metastases from lung carcinoma. Prospective randomized trial according to the level of lactate dehydrogenase. Strahlenther Onkol. 1994;170:155–161
  12. Chatani M, Teshima T, Hata K, et al. Prognostic factors in patients with brain metastases from lung carcinoma. Strahlenther Onkol. 1986;162:157–161
  13. Haie-Meder C, Pellae-Cosset B, Laplanche A, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol. 1993;26:111–116
  14. Harwood AR, Simson WJ. Radiation therapy of cerebral metastases: A randomized prospective clinical trial. Int J Radiat Oncol Biol Phys. 1977;2:1091–1094
  15. Kurtz JM, Gelber R, Brady LW, et al. The palliation of brain metastases in a favorable patient population: A randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1981;7:891–895
  16. Murray KJ, Scott C, Greenberg HM, et al. A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: A report of the Radiation Therapy Oncology Group (RTOG) 9104. Int J Radiat Oncol Biol Phys. 1997;39:571–574
  17. Davey P, Hoegler D, Ennis M, et al. A phase III study of accelerated versus conventional hypofractionated whole brain irradiation in patients of good performance status with brain metastases not suitable for surgical excision. Radiother Oncol. 2008;88:173–176
  18. DeAngelis LM, Delattre JY, Posner JB. Radiation-induced dementia in patients cured of brain metastases. Neurology. 1989;39:789–796
  19. Mehta MP, Rodrigus P, Terhaard CH, et al. Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol. 2003;21:2529–2536
  20. Meyers CA, Smith JA, Bezjak A, et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial. J Clin Oncol. 2004;22:157–165
  21. Brown PD, Asher AL, Farace E. Adjuvant whole brain radiotherapy: Strong emotions decide but rational studies are needed. Int J Radiat Oncol Biol Phys. 2008;70:1305–1309
  22. Li J, Bentzen SM, Li J, et al. Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int J Radiat Oncol Biol Phys. 2008;71:64–70
  23. DeAngelis LM, Currie VE, Kim JH, et al. The combined use of radiation therapy and lonidamine in the treatment of brain metastases. J Neurooncol. 1989;7:241–247
  24. Suh JH, Stea B, Nabid A, et al. Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol. 2006;24:106–114
  25. Berk L, Berkey B, Rich T, et al. Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int J Radiat Oncol Biol Phys. 2007;68:852–857
  26. Knisely JP, Berkey B, Chakravarti A, et al. A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118). Int J Radiat Oncol Biol Phys. 2008;71:79–86
  27. Antonadou D, Paraskevaidis M, Sarris G, et al. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol. 2002;20:3644–3650
  28. Bindal RK, Sawaya R, Leavens ME, et al. Surgical treatment of multiple brain metastases. J Neurosurg. 1993;79:210–216
  29. Bindal AK, Bindal RK, Hess KR, et al. Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg. 1996;84:748–754
  30. Pollock BE, Brown PD, Foote RL, et al. Properly selected patients with multiple brain metastases may benefit from aggressive treatment of their intracranial disease. J Neurooncol. 2003;61:73–80
  31. Iwadate Y, Namba H, Yamaura A. Significance of surgical resection for the treatment of multiple brain metastases. Anticancer Res. 2000;20:573–577
  32. Kondziolka D, Patel A, Lunsford LD, et al. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45:427–434
  33. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665–1672
  34. Aoyama H, Shirato H, Tago M, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial. JAMA. 2006;295:2483–2491

 This article summarizes the American College of Radiology (ACR) Appropriateness Criteria on Multiple Brain Metastases, excerpts of which are reprinted here with permission. Practitioners are encouraged to refer to the complete version at www.acr.org/ac.

 The ACR seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply society endorsement of the final document.

 Conflict of interest: none.

PII: S0360-3016(09)02822-3

doi: 10.1016/j.ijrobp.2009.07.1720

International Journal of Radiation Oncology * Biology * Physics
Volume 75, Issue 4 , Pages 961-965 , 15 November 2009

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