International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 918-925 , 1 July 2010

Interfraction and Intrafraction Changes in Amplitude of Breathing Motion in Stereotactic Liver Radiotherapy

Presented at the Canadian Association of Radiation Oncologists 2007 Annual Scientific Meeting, Toronto, Ontario, Canada.

  • Robert B. Case, BSc

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Douglas J. Moseley, PhD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Jan Jakob Sonke, PhD

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • ,
  • Cynthia L. Eccles, BSc

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Robert E. Dinniwell, MD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • John Kim, MD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Andrea Bezjak, MD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Michael Milosevic, MD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Kristy K. Brock, PhD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Laura A. Dawson, MD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationReprint requests to: Laura Dawson, M.D., Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada. Tel: (416) 946-2124; Fax: (416) 946-6566

Received 20 September 2008 ,Revised 12 August 2009 ,Accepted 14 September 2009.

References 

  1. Timmerman RD, Kavanagh BD, Cho LC, et al. Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol. 2007;25:947–952
  2. Potters L, Steinberg M, Rose C, et al. American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2004;60:1026–1032
  3. Suramo I, Paivansalo M, Myllyla V. Cranio-caudal movements of the liver, pancreas and kidneys in respiration. Acta Radiol Diagn. 1984;25:129–131
  4. Xi M, Liu M-Z, Deng X-W, et al. Defining internal target volume (ITV) for hepatocellular carcinoma using four-dimensional CT. Radiother Oncol. 2007;84:272–278
  5. Hof H, Herfarth K, Munter M, et al. Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2003;56:335–341
  6. Dawson LA, Brock KK, Kazanjian S, et al. The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. Int J Radiat Oncol Biol Phys. 2001;51:1410–1421
  7. Wong JW, Sharpe MB, Jaffray DA, et al. The use of active breathing control (ABC) to reduce margin for breathing motion. Int J Radiat Oncol Biol Phys. 1999;44:911–919
  8. Mageras GS, Yorke E. Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol. 2004;14:65–75
  9. Kubo HD, Hill BC. Respiration gated radiotherapy treatment: A technical study. Phys Med Biol. 1996;41:83–91
  10. Shirato H, Shimizu S, Shimizu T, et al. Real-time tumour-tracking radiotherapy. Lancet. 1999;353:1331–1332
  11. Brown WT, Wu X, Wen BC, et al. Early results of CyberKnife image-guided robotic stereotactic radiosurgery for treatment of lung tumors. Comput Aided Surg. 2007;12:253–261
  12. Nøttrup J, Korreman S, Pedersen A, et al. Intra- and interfraction breathing variations during curative radiotherapy for lung cancer. Radiother Oncol. 2007;84:40–48
  13. Hugo G, Vargas C, Liang J, et al. Changes in the respiratory pattern during radiotherapy for cancer in the lung. Radiother Oncol. 2006;78:326–331
  14. Dawson LA, Eccles C, Craig T. Individualized image guided iso-NTCP based liver cancer SBRT. Acta Oncol. 2006;45:856–864
  15. Tse RV, Hawkins M, Lockwood G, et al. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol. 2008;26:657–664
  16. Eccles CB, Kristy K, Bissonnette J-P, et al. Reproducibility of liver position using active breathing coordinator for liver cancer radiotherapy. Int J Radiat Oncol Biol Phys. 2006;64:751–759
  17. Keall PJ. 4-dimensional computed tomography imaging and treatment planning. Semin Radiat Oncol. 2004;14:81–90
  18. Sonke J-J, Zijp L, Remeijer P, et al. Respiratory correlated cone beam CT. Med Phys. 2005;32:1176–1186
  19. van Herk M. Errors and margins in radiotherapy. Semin Radiat Oncol. 2004;14:52–64
  20. Shirato H, Seppenwoolde Y, Kitamura K, et al. Intrafracional tumour motion: Lung and liver. Semin Radiat Oncol. 2004;14:10–18
  21. Seppenwoolde Y, Shirato H, Kitamura K, et al. Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:822–834
  22. Kitamura K, Shirato H, Seppenwoolde Y, et al. Tumor location, cirrhosis, and surgical history contribute to tumor movement in the liver, as measured during stereotactic irradiation using a real-time tumor-tracking radiotherapy system. Int J Radiat Oncol Biol Phys. 2003;56:221–228
  23. Guckenberger M, Meyer J, Wilbert J, et al. Intra-fractional uncertainties in cone-beam CT based image-guided radiotherapy (IGRT) of pulmonary tumors. Radiother Oncol. 2007;83:57–64
  24. Purdie TG, Bissonnette J-P, Franks K, et al. Cone-beam computed tomography for on-line image guidance of lung stereotactic radiotherapy: Localization, verification, and intrafraction tumor position. Int J Radiat Oncol Biol Phys. 2007;68:243–252
  25. Guckenberger M, Wilbert J, Meyer J, et al. Is a single respiratory correlated 4D-CT study sufficient for evaluation of breathing motion?. Int J Radiat Oncol Biol Phys. 2007;67:1352–1359
  26. Underberg R, Lagerwaard F, van Tinteren H, et al. Time trends in target volumes for stage I non-small-cell lung cancer after stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 2006;64:1221–1228
  27. Purdie T, Moseley D, Bissonnette J-P, et al. Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in stereotactic lung radiation therapy. Acta Oncol. 2006;45:915–922
  28. Langen KM, Willoughby TR, Meeks SL, et al. Observations on real-time prostate gland motion using electromagnetic tracking. Int J Radiat Oncol Biol Phys. 2008;71:1084–1090
  29. Ozhasoglu C, Murphy MJ, Martin J. Issues in respiratory motion compensation during external-beam radiotherapy. Int J Radiat Oncol Biol Phys. 2002;52:1389–1399
  30. Hoisak JDP, Sixel KE, Tirona R, et al. Correlation of lung tumor motion with external surrogate indicators of respiration. Int J Radiat Oncol Biol Phys. 2004;60:1298–1306
  31. von Siebenthal M, Szekely G, Lomax A, et al. Systematic errors in respiratory gating due to intrafraction deformations of the liver. Med Phys. 2007;34:3620–3629
  32. Brock KK, Hawkins M, Eccles C, et al. Improving image-guided target localization through deformable registration. IGRT 2008 special. Acta Oncol. 2008;47:1279–1285
  33. Case RB, Sonke J-J, Moseley DJ, Kim J, Brock KK, Dawson LA. Inter- and Intra-fraction Reproducibility of Liver Position in Non-breath Hold Stereotactic Body Radiotherapy. Int J Radiat Oncol Biol Phys. 2009 September;75(1):302–308

 Funded in part from the National Cancer Institute of Canada, the Canadian Cancer Society and Elekta Oncology Systems.

PII: S0360-3016(09)03201-5

doi: 10.1016/j.ijrobp.2009.09.008

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 918-925 , 1 July 2010

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