International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 4 , Pages 1081-1085 , 15 November 2010

Rectal Dose–Volume Histogram Parameters Are Associated With Long-Term Patient-Reported Gastrointestinal Quality of Life After Conventional and High-Dose Radiation for Prostate Cancer: A Subgroup Analysis of a Randomized Trial

  • Paul L. Nguyen, M.D

      Affiliations

    • Harvard Radiation Oncology Program, Boston, MA
    • Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests to: Paul L. Nguyen, M.D., Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115. Tel: (617) 732-7936; Fax: (617) 732-0912
    • ,
  • Ronald C. Chen, M.D., M.P.H

      Affiliations

    • Harvard Radiation Oncology Program, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • Karen E. Hoffman, M.D., M.H.Sc., M.P.H

      Affiliations

    • Harvard Radiation Oncology Program, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • Alexei Trofimov, Ph.D

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • Jason A. Efstathiou, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • John J. Coen, M.D

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • William U. Shipley, M.D

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • Anthony L. Zietman, M.D

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • ,
  • James A. Talcott, M.D., M.P.H

      Affiliations

    • Department of Medical Oncology, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA

Received 23 July 2009 ,Revised 13 September 2009 ,Accepted 14 September 2009.

References 

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  18. Clark JA, Talcott JA. Symptom indexes to assess outcomes of treatment for early prostate cancer. Med Care. 2001;39:1118–1130
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  20. Kuban D, Pollack A, Huang E, et al. Hazards of dose escalation in prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys. 2003;57:1260–1268
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  23. Vordermark D, Schwab M, Ness-Dourdoumas R, et al. Association of anorectal dose–volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate. Radiother Oncol. 2003;69:209–214
  24. Dale E, Olsen DR, Fossa SD. Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy. Int J Radiat Oncol Biol Phys. 1999;43:385–391

 Conflict of interest: none.

PII: S0360-3016(09)03208-8

doi: 10.1016/j.ijrobp.2009.09.015

International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 4 , Pages 1081-1085 , 15 November 2010

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