International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S28-S35, 1 March 2010

Radiation Dose–Volume Effects of Optic Nerves and Chiasm

  • Charles Mayo, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA
    • Corresponding Author InformationReprint requests to: Charles Mayo, Ph.D., Department of Radiation Oncology, HB-200, University of Massachusetts Memorial Medical Center, 55 Lake Ave. N, Worcester, MA 01655. Tel: (774) 442-5551; Fax: (774) 422-5006
    • ,
  • Mary K. Martel, Ph.D.

      Affiliations

    • Department of Radiation Oncology, M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Lawrence B. Marks, M.D.

      Affiliations

    • Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • John Flickinger, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Pittsburgh Presbyterian Hospital, Pittsburgh, PA
    • ,
  • Jiho Nam, M.D.

      Affiliations

    • Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • John Kirkpatrick, M.D., Ph.D.

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham, NC

Received 14 November 2008; received in revised form 10 July 2009; accepted 15 July 2009.

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose–volume measures were reviewed. Few studies have adequate data for dose–volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at ≈1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

Optic, Nerve, Chiasm, Tolerance, Radiotherapy

 

 Conflict of interest: none.

PII: S0360-3016(09)03284-2

doi:10.1016/j.ijrobp.2009.07.1753

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S28-S35, 1 March 2010

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