Use of Normal Tissue Complication Probability Models in the Clinic

Marks, Lawrence B.; Yorke, Ellen D.; Jackson, Andrew; Ten Haken, Randall K.; Constine, Louis S.; Eisbruch, Avraham; Bentzen, Søren M.; Nam, Jiho; Deasy, Joseph O.

doi:10.1016/j.ijrobp.2009.07.1754

« Previous Next »International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S10-S19, 1 March 2010

Use of Normal Tissue Complication Probability Models in the Clinic

Lawrence B. Marks, M.D.
- Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC
- Reprint requests to: Lawrence B. Marks, M.D., Department of Radiation Oncology, Box 7512 University of North Carolina, Chapel Hill, NC 27514. Tel: (919) 966-0400; Fax: (919) 966-7681
Ellen D. Yorke, Ph.D.
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY
Andrew Jackson, Ph.D.
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY
Randall K. Ten Haken, Ph.D.
- Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
Louis S. Constine, M.D.
- Department of Radiation Oncology, University of Rochester Cancer Center, Rochester, NY
Avraham Eisbruch, M.D.
- Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
Søren M. Bentzen, Ph.D.
- Department of Human Oncology, University of Wisconsin School of Medicine, Madison, WI
Jiho Nam, M.D.
- Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC
Joseph O. Deasy, Ph.D.
- Department of Radiation Oncology, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO

Received 6 January 2009; received in revised form 1 July 2009; accepted 2 July 2009.

The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A “clinician's view” on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.

QUANTEC, NTCP

Conflict of interest: none.

PII: S0360-3016(09)03288-X

doi:10.1016/j.ijrobp.2009.07.1754

« Previous Next »International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S10-S19, 1 March 2010

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