International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S10-S19 , 1 March 2010

Use of Normal Tissue Complication Probability Models in the Clinic

  • Lawrence B. Marks, M.D.

      Affiliations

    • Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC
    • Corresponding Author InformationReprint requests to: Lawrence B. Marks, M.D., Department of Radiation Oncology, Box 7512 University of North Carolina, Chapel Hill, NC 27514. Tel: (919) 966-0400; Fax: (919) 966-7681
    • ,
  • Ellen D. Yorke, Ph.D.

      Affiliations

    • Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY
    • ,
  • Andrew Jackson, Ph.D.

      Affiliations

    • Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY
    • ,
  • Randall K. Ten Haken, Ph.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
    • ,
  • Louis S. Constine, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Rochester Cancer Center, Rochester, NY
    • ,
  • Avraham Eisbruch, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
    • ,
  • Søren M. Bentzen, Ph.D.

      Affiliations

    • Department of Human Oncology, University of Wisconsin School of Medicine, Madison, WI
    • ,
  • Jiho Nam, M.D.

      Affiliations

    • Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC
    • ,
  • Joseph O. Deasy, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO

Received 6 January 2009 ,Revised 1 July 2009 ,Accepted 2 July 2009.

References 

  1. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21:109–122
  2. Kirkpatrick J, Meyer J, Marks L. The linear-quadratic model is inappropriate to model high-dose per fraction effects. Semin Radiat Oncol. 2008;18:240–243
  3. Trotti A, Colevas AD, Setser A, et al. CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003;13:176–181
  4. Langer M, Morrill SS, Lane R. A test of the claim that plan rankings are determined by relative complication and tumor-control probabilities. Int J Radiat Oncol Biol Phys. 1998;41:451–457
  5. Agren A, Brahme A, Turesson I. Optimization of uncomplicated control for head and neck tumors. Int J Radiat Oncol Biol Phys. 1990;19:1077–1085
  6. Miften MGO, Parda DS, Prosnitz RG, Marks LM. Using quality of life information to rationally incorporate normal tissue effects into treatment plan evaluation and scoring. In:  Rubin PCL,  Marks LB,  Okunieff P editor. Cured I—lent. Late effects of cancer treatment on normal tissue. 1st ed. New York: Springer; 2007;
  7. Amols HI, Zaider M, Hayes MK, et al. Physician/patient-driven risk assignment in radiation oncology: Reality or fancy?. Int J Radiat Oncol Biol Phys. 1997;38:455–461
  8. Morris DE. Clinical experience with retreatment for palliation. Semin Radiat Oncol. 2000;10:210–221
  9. Sadikov E, Bezjak A, Yi QL, et al. Value of whole brain re-irradiation for brain metastases—single centre experience. Clin Oncol. 2007;19:532–538
  10. Kurup P, Reddy S, Hendrickson FR. Results of re-irradiation for cerebral metastases. Cancer. 1980;46:2587–2589
  11. Pfeffer MR, Rabin T, Tsvang L, et al. Orbital lymphoma: Is it necessary to treat the entire orbit?. Int J Radiat Oncol Biol Phys. 2004;60:527–530
  12. Hope AJ, Lindsay PE, El Naqa I, et al. Clinical, dosimetric, and location-related factors to predict local control in non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2005;63:S231–S231
  13. Engels B, Soete G, Verellen D, et al. Conformal Arc Radiotherapy for Prostate Cancer: Increased Biochemical Failure in Patients With Distended Rectum on the Planning Computed Tomogram Despite Image Guidance by Implanted Markers. Int J Radiat Oncol Biol Phys. 2009;74:388–391
  14. Zagars GK, Schultheiss TE, Peters LJ. Inter-tumor heterogeneity and radiation dose-control curves. Radiother Oncol. 1987;8:353–361
  15. Jolles B. Area factor in skin reaction. Br Emp Cancer Campaign Rep. 1939;16
  16. Lyman JT. Complication probability as assessed from dose-volume histograms. Radiat Res Suppl. 1985;8:S13–S19
  17. Mohan R, Mageras GS, Baldwin B, et al. Clinically relevant optimization of 3-D conformal treatments. AAPM. 1992;19:933–944
  18. Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys. 1999;26:1100
  19. Kutcher GJ, Burman C, Brewster L, et al. Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations. Int J Radiat Oncol Biol Phys. 1991;21:137–146
  20. Burman C, Kutcher GJ, Emami B, et al. Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys. 1991;21:123–135
  21. Withers HR, Tayor JMG, Maciejewski B. Treatment volume and tissue tolerance. Int J Radiat Oncol Biol Phys. 1988;15:751–759
  22. Jackson A, Ten Haken RK, Robertson JM, et al. Analysis of clinical complication data for radiation hepatitis using a parallel architecture model. Int J Radiat Oncol Biol Phys. 1995;31:883–891
  23. Niemierko A, Goitein M. Calculation of normal tissue complication probability and dose-volume histogram reduction schemes for tissues with a critical element architecture. Radiother Oncol. 1991;20:166–176
  24. Graham MV, Purdy JA, Emami B, et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 1999;45:323–329
  25. El Naqa I, Bradley J, Blanco AI, et al. Multivariable modeling of radiotherapy outcomes including dose-volume and clinical factors. Int J Radiat Oncol Biol Phys. 2006;64:1275–1286
  26. Jackson A, Yorke E. NTCP and TCP for treatment planning. In: Memorial Sloan-Kettering Cancer Center  editors. A practical guide to intensity-modulated radiation therapy. Madison, WI: Medical Physics Pubishers; 2003;p. 185–220
  27. Deasy JO, Niemierko A, Herbert D, et al. Methodological issues in radiation dose-volume outcome analyses: Summary of a joint AAPM/NIH workshop. Med Phys. 2002;29:2109–2127
  28. Yorke ED. Modeling the effects of inhomogeneous dose distributions in normal tissues. Semin Radiat Oncol. 2001;11:197–209
  29. Moiseenko J, Deasy O, Van Dyk J. Radiobiological modeling for treatment planning. In:  Van Dyk J editors. The modern technology of radiation oncology: A compendium for medical physicists and radiation oncologists, vol. 2. Madison, WI: Medical Physics Publishing; 2005;p. 185–220

 Conflict of interest: none.

PII: S0360-3016(09)03288-X

doi: 10.1016/j.ijrobp.2009.07.1754

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S10-S19 , 1 March 2010

Article Tools

* Image Usage & Resolution