International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S58-S63 , 1 March 2010

Radiotherapy Dose–Volume Effects on Salivary Gland Function

  • Joseph O. Deasy, Ph.D.

      Affiliations

    • Department of Radiation Oncology, Washington University School of Medicine and Alvin J. Siteman Cancer Center, St. Louis, MO
    • Corresponding Author InformationReprint requests to: Joseph O. Deasy, Ph.D., Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Pl., St. Louis, MO 63110. Tel: (314) 362-1420; Fax: (314) 362-8521
  • ,
  • Vitali Moiseenko, Ph.D.

      Affiliations

    • Department of Medical Physics, British Columbia Cancer Agency–Vancouver Cancer Center, Vancouver, BC, Canada
  • ,
  • Lawrence Marks, M.D.

      Affiliations

    • Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
  • ,
  • K.S. Clifford Chao, M.D.

      Affiliations

    • Department of Radiation Oncology, Columbia School of Medicine, New York, NY
  • ,
  • Jiho Nam, Ph.D.

      Affiliations

    • Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
  • ,
  • Avraham Eisbruch, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI

Received 6 February 2009 ,Revised 8 June 2009 ,Accepted 12 June 2009.

References 

  1. Dawes C, Wood CM. The contribution of oral minor mucous gland secretions to the volume of whole saliva in man. Arch Oral Biol. 1973;18:337–342
  2. Buus S, Grau C, Munk O, et al. Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET. Radiother Oncol. 2006;78:262–269
  3. Astreinidou E, Roesink JM, Raaijmakers CP, et al. 3D MR sialography as a tool to investigate radiation-induced xerostomia: Feasibility study. Int J Radiat Oncol Biol Phys. 2007;68:1310–1319
  4. Chao KSC, Deasy JO, Markman J, et al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: Initial results. Int J Radiat Oncol Biol Phys. 2001;49:907–916
  5. Meirovitz A, Murdoch-Kinch C, Schipper M, et al. Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2006;66:445–453
  6. Blanco AI, Chao KSC, El Naqa I, et al. Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:1055–1069
  7. Eisbruch A, Kim KM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;50:695–704
  8. Maes A, Weltens C, Flamen P, et al. Preservation of parotid function with uncomplicated conformal radiotherapy. Radiother Oncol. 2002;63:203–211
  9. Li Y, Taylor J, Ten Haken R, et al. The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2007;67:660–669
  10. Braam PM, Roesink JM, Raaijmakers CP, et al. Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy. Radiat Oncol. 2007;2:3
  11. Robar JL, Day A, Clancey J, et al. Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2007;68:1121–1130
  12. Saarilahti K, Kouri M, Collan J, et al. Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer. Radiother Oncol. 2006;78:270–275
  13. Portaluri M, Fucilli F, Castagna R, et al. Three-dimensional conformal radiotherapy for locally advanced (stage II and worse) head-and-neck cancer: Dosimetric and clinical evaluation. Int J Radiat Oncol Biol Phys. 2006;66:1036–1043
  14. Roesink JM, Moerland MA, Battermann JJ, et al. Quantitative dose–volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region. Int J Radiat Oncol Biol Phys. 2001;51:938–946
  15. Roesink JM, Moerland MA, Hoekstra A. Scintigraphic assessment of early and late parotid gland function after radiotherapy for head-and-neck cancer: A prospective study of dose–volume response relationships. Int J Radiat Oncol Biol Phys. 2004;58:1451–1460
  16. Bussels B, Maes A, Flamen P, et al. Dose–response relationships within the parotid gland after radiotherapy for head and neck cancer. Radiother Oncol. 2004;73:297–306
  17. Eisbruch A, Ten Haken R, Kim H, et al. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 1999;45:577–587
  18. Munter MW, Karger CP, Hoffner SG, et al. Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy. Int J Radiat Oncol Biol Phys. 2007;58:175–184
  19. Munter MW, Hoffner S, Hof H, et al. Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without amifostine. Int J Radiat Oncol Biol Phys. 2007;67:651–659
  20. Rudat V, Munter M, Rades D, et al. The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy. Radiother Oncol. 2008;89:71–80
  21. Deasy JO, Chao KSC, Markman J. Uncertainties in model-based outcome predictions for treatment planning. Int J Radiat Oncol Biol. 2001;51:1389–1399
  22. Franzen L, Sundstrom S, Karlsson M, et al. Fractionated irradiation and early changes in noradrenaline induced potassium efflux (86Rb+) in rat parotid gland. Acta Oncol. 1992;31:359–364
  23. Leslie MD, Dische S. The early changes in salivary gland function during and after radiotherapy for head and neck cancer. Radiother Oncol. 1994;30:26–32
  24. Price RE, Ang KK, Stephens LC, et al. Effects of continuous hyperfractionated accelerated and conventionally fractionated radiotherapy on the parotid and submandibular salivary glands of rhesus monkeys. Radiother Oncol. 1995;34:39–46
  25. Lombaert IM, Brunsting JF, Wierenga PK, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE. 2008;3:e2063
  26. Konings AW, Cotteleer F, Faber H, et al. Volume effects and region-dependent radiosensitivity of the parotid gland. Int J Radiat Oncol Biol Phys. 2005;62:1090–1095
  27. Saarilahti K, Kouri M, Collan J, et al. Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer. Radiother Oncol. 2006;78:270–275
  28. Jellema AP, Doornaert P, Slotman BJ, et al. Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?. Radiother Oncol. 2005;77:164–171
  29. Seikaly H, Jha N, Harris JR, et al. Long-term outcomes of submandibular gland transfer for prevention of postradiation xerostomia. Arch Otolaryngol Head Neck Surg. 2004;130:956–961
  30. Murdoch-Kinch CA, Kim HM, Vineberg KA, et al. Dose–effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:373–382
  31. Munter MW, Hoffner S, Hof H, et al. Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without amifostine. Int J Radiat Oncol Biol Phys. 2007;67:651–659

 Partially funded by National Institutes of Health Grant R01 CA85181 (to J. O. Deasy) and Grant CA69579 (L. B. Marks) and by the American Association of Medical Physicists and the American Society of Therapeutic Radiology.

 Conflict of interest: none.

PII: S0360-3016(09)03289-1

doi: 10.1016/j.ijrobp.2009.06.090

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S58-S63 , 1 March 2010