International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S50-S57 , 1 March 2010

Radiation Therapy and Hearing Loss

  • Niranjan Bhandare, M.S.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida
  • ,
  • Andrew Jackson, Ph.D.

      Affiliations

    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Avraham Eisbruch, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan
  • ,
  • Charlie C. Pan, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Michigan
  • ,
  • John C. Flickinger, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Pittsburgh Medical Center
  • ,
  • Patrick Antonelli, M.D.

      Affiliations

    • Department of Otolaryngology, University of Florida College of Medicine, Gainesville, Florida
  • ,
  • William M. Mendenhall, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida
    • Corresponding Author InformationReprint requests to: William M. Mendenhall, M.D., PO Box 100385, Gainesville, FL 32610. Tel: (352) 265-0287; Fax: (352) 265-7045

Received 18 March 2009 ,Revised 23 April 2009 ,Accepted 27 April 2009.

References 

  1. Jereczek-Fossa BA, Zarowski A, Milani F, et al. Radiotherapy-induced ear toxicity. Cancer Treat Rev. 2003;29:417–430
  2. Bhide SA, Harrington KJ, Nutting CM. Otological toxicity after postoperative radiotherapy for parotid tumours. Clin Oncol (R Coll Radiol). 2007;19:77–82
  3. Raaijmakers E, Engelen AM. Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation? A systematic review of the literature. Radiother Oncol. 2002;65:1–7
  4. Bhandare N, Antonelli PJ, Morris CG, et al. Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys. 2007;67:469–479
  5. Pan CC, Eisbruch A, Lee JS, et al. Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys. 2005;61:1393–1402
  6. Chen WC, Jackson A, Budnick AS, et al. Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer. 2006;106:820–829
  7. Kwong DL, Wei WI, Sham JS, et al. Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: A prospective study of the effect of radiation and cisplatin treatment. Int J Radiat Oncol Biol Phys. 1996;36:281–289
  8. Oh YT, Kim CH, Choi JH, et al. Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma. Radiother Oncol. 2004;72:79–82
  9. Committee on Hearing and Equilibrium . Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma). American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc. Otolaryngol Head Neck Surg. 1995;113:179–180
  10. Honore HB, Bentzen SM, Moller K, et al. Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: Individualized risk estimation. Radiother Oncol. 2002;65:9–16
  11. Ho WK, Wei WI, Kwong DL, et al. Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: A prospective study. Head Neck. 1999;21:547–553
  12. van der Putten L, de Bree R, Plukker JT, et al. Permanent unilateral hearing loss after radiotherapy for parotid gland tumors. Head Neck. 2006;28:902–908
  13. Niranjan A, Lunsford LD, Flickinger JC, et al. Dose reduction improves hearing preservation rates after intracanalicular acoustic tumor radiosurgery. Neurosurgery. 1999;45:753–762
  14. Pollack AG, Marymont MH, Kalapurakal JA, et al. Acute neurological complications following gamma knife surgery for vestibular schwannoma. Case report. J Neurosurg. 2005;103:546–551
  15. Subach BR, Kondziolka D, Lunsford LD, et al. Stereotactic radiosurgery in the management of acoustic neuromas associated with neurofibromatosis Type 2. J Neurosurg. 1999;90:815–822
  16. Linskey ME, Lunsford LD, Flickinger JC. Tumor control after stereotactic radiosurgery in neurofibromatosis patients with bilateral acoustic tumors. Neurosurgery. 1992;31:829–838
  17. Pacholke HD, Amdur RJ, Schmalfuss IM, et al. Contouring the middle and inner ear on radiotherapy planning scans. Am J Clin Oncol. 2005;28:143–147
  18. Low WK, Toh ST, Wee J, et al. Sensorineural hearing loss after radiotherapy and chemoradiotherapy: A single, blinded, randomized study. J Clin Oncol. 2006;24:1904–1909
  19. Flickinger JC, Kondziolka D, Lunsford LD. Dose and diameter relationships for facial, trigeminal, and acoustic neuropathies following acoustic neuroma radiosurgery. Radiother Oncol. 1996;41:215–219
  20. Pollock BE, Lunsford LD, Kondziolka D, et al. Outcome analysis of acoustic neuroma management: A comparison of microsurgery and stereotactic radiosurgery. Neurosurgery. 1995;36:215–229
  21. Massager N, Nissim O, Delbrouck C, et al. Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery. Int J Radiat Oncol Biol Phys. 2006;64:1331–1340
  22. Paek SH, Chung HT, Jeong SS, et al. Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma. Cancer. 2005;104:580–590
  23. Andrews DW, Suarez O, Goldman HW, et al. Stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of acoustic schwannomas: Comparative observations of 125 patients treated at one institution. Int J Radiat Oncol Biol Phys. 2001;50:1265–1278
  24. Combs SE, Volk S, Schulz-Ertner D, et al. Management of acoustic neuromas with fractionated stereotactic radiotherapy (FSRT): Long-term results in 106 patients treated in a single institution. Int J Radiat Oncol Biol Phys. 2005;63:75–81
  25. Williams J. Fractionated radiotherapy for acoustic neuromas. Congress of Neurological Surgeons: 50th Annual Meeting 2000. San Antonio, TX: 155.
  26. Meijer OW, Vandertop WP, Baayen JC, et al. Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study. Int J Radiat Oncol Biol Phys. 2003;56:1390–1396
  27. Moretti JA. Sensori-neural hearing loss following radiotherapy to the nasopharynx. Laryngoscope. 1976;86:598–602
  28. Grau C, Overgaard J. Postirradiation sensorineural hearing loss: A common but ignored late radiation complication. Int J Radiat Oncol Biol Phys. 1996;36:515–517
  29. Flickinger JC, Lunsford LD, Linskey ME, et al. Gamma knife radiosurgery for acoustic tumors: multivariate analysis of four year results. Radiother Oncol. 1993;27:91–98
  30. Rowe JG, Radatz MW, Walton L, et al. Clinical experience with gamma knife stereotactic radiosurgery in the management of vestibular schwannomas secondary to type 2 neurofibromatosis. J Neurol Neurosurg Psychiatry. 2003;74:1288–1293
  31. Merchant TE, Gould CJ, Xiong X, et al. Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors. Int J Radiat Oncol Biol Phys. 2004;58:1194–1207
  32. Hua C, Bass JK, Khan R, et al. Hearing loss after radiotherapy for pediatric brain tumors: Effect of cochlear dose. Int J Radiat Oncol Biol Phys. 2008;72:892–899
  33. Flickinger JC, Kondziolka D, Niranjan A, et al. Acoustic neuroma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2004;60:225–230
  34. Hirsch A, Noren G. Audiological findings after stereotactic radiosurgery in acoustic neurinomas. Acta Otolaryngol. 1988;106:244–251
  35. Noren G, Greitz D, Hirsch A, et al. Gamma knife surgery in acoustic tumors. Acta Neurochir Suppl (Wien). 1993;58:104–107
  36. Foote RL, Coffey RJ, Swanson JW, et al. Stereotactic radiosurgery using the gamma knife for acoustic neuromas. Int J Radiat Oncol Biol Phys. 1995;32:1153–1160
  37. Flickinger JC, Kondziolka D, Pollock BE, et al. Evolution in technique for vestibular schwannoma radiosurgery and effect on outcome. Int J Radiat Oncol Biol Phys. 1996;36:275–280
  38. Kondziolka D, Lunsford LD, McLaughlin MR, et al. Long-term outcomes after radiosurgery for acoustic neuromas. N Engl J Med. 1998;339:1426–1433
  39. Lunsford LD, Kondziolka D, Flickinger JC, et al. Acoustic neuroma management: Evolution and revolution. In:  Kondziolka D editors. Radiosurgery. 2nd ed. Basel: Karger; 1998;1–7
  40. Flickinger JC, Kondziolka D, Niranjan A, et al. Results of acoustic neuroma radiosurgery: An analysis of 5 years' experience using current methods. J Neurosurg. 2001;94:1–6
  41. Williams JA. Fractionated stereotactic radiotherapy for acoustic neuromas. Int J Radiat Oncol Biol Phys. 2002;54:500–504

 Conflict of interest: None.

PII: S0360-3016(09)03298-2

doi: 10.1016/j.ijrobp.2009.04.096

International Journal of Radiation Oncology * Biology * Physics
Volume 76, Issue 3, Supplement , Pages S50-S57 , 1 March 2010