International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 942-949 , 1 July 2010

Volumetric Modulation Arc Radiotherapy Compared With Static Gantry Intensity-Modulated Radiotherapy for Malignant Pleural Mesothelioma Tumor: A Feasibility Study

  • Marta Scorsetti, M.D.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Mario Bignardi, M.D.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Alessandro Clivio, M.Sc.

      Affiliations

    • Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
  • ,
  • Luca Cozzi, Ph.D.

      Affiliations

    • Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    • Corresponding Author InformationReprint requests to: Luca Cozzi, Ph.D., Department of Radiation Oncology, Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona 6504 Switzerland. Tel: (+41) 91-811-9202; Fax: (+41) 91-811-8678
  • ,
  • Antonella Fogliata, M.Sc.

      Affiliations

    • Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
  • ,
  • Paola Lattuada, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Pietro Mancosu, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Piera Navarria, M.D.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Giorgia Nicolini, M.Sc.

      Affiliations

    • Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
  • ,
  • Gaetano Urso, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Eugenio Vanetti, M.Sc.

      Affiliations

    • Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
  • ,
  • Sabrina Vigorito, M.Sc.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy
  • ,
  • Armando Santoro, M.D.

      Affiliations

    • Department of Radiation Oncology, Istituto Clinico Humanitas, Rozzano, Italy

Received 2 June 2009 ,Revised 12 August 2009 ,Accepted 18 September 2009.

References 

  1. Robinson BW, Lake RA. Advance in malignant mesothelioma. N Engl J Med. 2005;353:1591–1603
  2. Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21:2636–2644
  3. Flores RM, Krug LM, Rosenzweig KE, et al. Induction chemotherapy, extrapleural pneumonectomy, and postoperative high-dose radiotherapy for locally advanced malignant pleural mesothelioma: A phase II trial. J Thorac Oncol. 2006;1:289–295
  4. Rea F, Marulli G, Bortolotti L, et al. Induction chemotherapy, extrapleural pneumonectomy (EPP) and adjuvant hemi-thoracic radiation in malignant pleural mesothelioma (MPM): Feasibility and results. Lung Cancer. 2007;57:89–95
  5. Pass HI, Kranda K, Temeck BK, et al. Surgically debulked malignant pleural mesothelioma: Results and prognostic factors. Ann Surg Oncol. 1997;4:215–222
  6. Kutcher GJ, Kester C, Greenblatt D, et al. Technique for external beam treatment for mesothelioma. Int J Radiat Oncol Biol Phys. 1987;13:1747–1752
  7. Yajnik S, Rosenzweig KE, Mychalczak B, et al. Hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2003;56:1319–1326
  8. Krayenbuehl J, Oertel S, Davis JB, et al. Combined photon and electron three-dimensional conformal versus intensity-modulated radiotherapy with integrated boost for adjuvant treatment of malignant pleural mesothelioma after pleuropneumonectomy. Int J Radiat Oncol Biol Phys. 2007;69:1593–1599
  9. Hilaris BS, Nori D, Kwong E, et al. Pneurectomy and intraoperative brachytherapy and post-operative radiation in the treatment of malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 1984;10:325–331
  10. Lee TT, Everett DL, Shu HJ, et al. Radical pleurectomy/decortication and intraoperative radiotherapy followed by conformal radiation with or without chemotherapy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2002;124:1183–1189
  11. Miles EF, Larrer NA, Kelsey CR, et al. Intensity-modulated radiotherapy for resected mesothelioma: The Duke experience. Int J Radiat Oncol Biol Phys. 2008;71:1143–1150
  12. Chan MF, Chui CS, Song Y, et al. A novel radiation therapy technique for malignant pleural mesothelioma combining electron with intensity-modulated photons. Radiother Oncol. 2006;79:218–223
  13. Allen AM, Czerminska M, Janne PA, et al. Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys. 2006;65:640–645
  14. Allen AM, Schofield D, Hacker F, et al. Restricted field IMRT dramatically enhances IMRT planning for mesothelioma. Int J Radiat Oncol Biol Phys. 2007;69:1587–1592
  15. Sterzing F, Sroka-Perez G, Schubert K, et al. Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: Helical tomotherapy compared with steep-and-shoot IMRT. Radiother Oncol. 2008;86:251–257
  16. Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008;35:310–317
  17. Clivio A, Fogliata A, Franzetti-Pellanda A, et al. Volumetric arc modulated radiotherapy for carcinomas of the anal canal: A treatment planning comparison with fixed field IMRT. Radiother Oncol. 2009;92:118–124
  18. Cozzi L, Dinshaw KA, Shrivastava SK, et al. A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother Oncol. 2008;89:180–191
  19. Fogliata A, Clivio A, Nicolini G, et al. Intensity modulation with photons for benign intracranial tumours: A planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol. 2008;89:254–262
  20. Kjær-Kristoffersen F, Ohlhues L, Medin J, et al. RapidArc volumetric modulated therapy planning for prostate cancer patients. Acta Oncol. 2008;14:1–6
  21. Palma D, Vollans E, James K, et al. Volumetric modulated arc therapy for delivery of prostate radiotherapy: Comparison with intensity modulated radiotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:996–1001
  22. Vanetti E, Clivio A, Nicolini G, et al. Volumetric arc modulated radiotherapy for carcinomas of the oro-pharynx, hypopharynx and larynx: A treatment planning comparison with fixed field IMRT. Radiother Oncol. 2009;92:111–117
  23. Lagerwaard F, Meijer O, van del Hoorn E, et al. Volumetric modulated arc radiotherapy for vestibular schwannomas. Int J Radiat Oncol Biol Phys. 2009;74:610–615
  24. Verbakel W, Cuijpers J, Hoffmans D, et al. Volumetric intensity modulated arc therapy versus conventional IMRT in head and neck cancer: A comparative planning and dosimetric study. Int J Radiat Oncol Biol Phys. 2009;74:252–259
  25. Ahamad A, Stevens CW, Smythe WR, et al. Intensity-modulated radiation therapy: A novel approach to the management of malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2003;55:768–775
  26. Rusch VW, Rosenzweig K, Venkatraman E, et al. A phase II trial of surgical resection and adjuvant high dose hemithoracic radiation for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2001;122:788–795
  27. Ulmer W, Pyyry J, Kaissl WA. 3D photon superposition/convolution algorithm and its foundation on results of Monte Carlo calculations. Phys Med Biol. 2005;50:1767–1790
  28. Nicolini G, Vanetti E, Clivio A, et al. The GLAaS algorithm for portal dosimetry and quality assurance of RapidArc, an intensity modulated rotational therapy. Radiat Oncol. 2008;3:24
  29. Nicolini G, Fogliata A, Vanetti E, et al. GLAaS: An absolute dose calibration algorithm for an amorphous silicon portal imager—Applications to IMRT verifications. Med Phys. 2006;33:2839–2851
  30. Low DA, Harms WB, Mutic S, et al. A technique for quantitative evaluation of dose distributions. Med Phys. 1998;25:656–661

 Conflict of interest: L. Cozzi acts as Scientific Advisor to Varian Medical Systems and is Head of Research and Technological Development, Oncology Institute of Southern Switzerland, IOSI, Bellinzona, Italy.

PII: S0360-3016(09)03332-X

doi: 10.1016/j.ijrobp.2009.09.053

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 942-949 , 1 July 2010