Initial Experience With Volumetric IMRT (RapidArc) for Intracranial Stereotactic Radiosurgery

Mayo, Charles S.; Ding, Linda; Addesa, Anthony; Kadish, Sidney; Fitzgerald, T.J.; Moser, Richard

doi:10.1016/j.ijrobp.2009.10.005

« Previous Next »International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 5 , Pages 1457-1466, 1 December 2010

Initial Experience With Volumetric IMRT (RapidArc) for Intracranial Stereotactic Radiosurgery

Charles S. Mayo, Ph.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
- Reprint requests to: Charles S. Mayo, Ph.D., Department of Radiation Oncology, HB200, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655. Tel: (744) 442-5560; Fax: (774) 442-5006
Linda Ding, Ph.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
Anthony Addesa, M.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
Sidney Kadish, M.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
T.J. Fitzgerald, M.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
Richard Moser, M.D.
- Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA
- Division of Neurosurgery, Department of Surgery, University of Massachusetts Medical School, Worcester, MA

Received 6 July 2009; received in revised form 6 October 2009; accepted 7 October 2009. published online 08 March 2010.

Purpose

Initial experience with delivering frameless stereotactic radiotherapy (SRT) using volumetric intensity-modulated radiation therapy (IMRT) delivered with RapidArc is presented.

Methods and Materials

Treatment details for 12 patients (14 targets) with a mean clinical target volume (CTV) of 12.8 ± 4.0 cm³ were examined. Dosimetric indices for conformality, homogeneity, and dose gradient were calculated and compared with published results for other frameless, intracranial SRT techniques, including CyberKnife, TomoTherapy, and static-beam IMRT. Statistics on setup and treatment times and per patient dose validations were examined.

Results

Dose indices compared favorably with other techniques. Mean conformality, gradient, and homogeneity index values were 1.10 ± 0.11, 64.9 ± 14.1, 1.083 ± 0.026, respectively. Median treatment times were 4.8 ± 1.7 min.

Conclusion

SRT using volumetric IMRT is a viable alternative to other techniques and enables short treatment times. This is anticipated to have a positive impact on radiobiological effect and for facilitating wider use of SRT.

RapidArc, Radiosurgery, Treatment time