International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 645-647 , 1 July 2010

Adjuvant Pancreatic Cancer Therapy: No One Should Go It Alone or Be Left Behind

  • Joseph M. Herman, M.D., M.Sc.

      Affiliations

    • Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD
    • ,
  • William F. Regine, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Maryland, Baltimore, MD
    • Corresponding Author InformationReprint requests to: William F. Regine, M.D., Department of Radiation Oncology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201. Tel: (410) 328-2326; Fax: (410) 328-6911

Received 22 October 2009 ,Accepted 20 November 2009.

References 

  1. Ogawa , et al. Intraoperative Radiotherapy for Resected Pancreatic Cancer: A Multi-institutional Retrospective Analysis of 210 patients. Int J Radiat Oncol Biol Phys. 2009;77:734–742
  2. Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial. JAMA. 2008;299:1019–1026
  3. Gunderson LL, Nelson H, Martenson JA, et al. Locally advanced primary colorectal cancer: Intraoperative electron and external beam irradiation +/- 5-FU. Int J Radiat Oncol Biol Phys. 1997;37:601–614
  4. Abrams RA, Winter KA, Regine WF, et al. RTOG 97–04: Radiotherapy quality assurance (QA) review and survival (Abstr.). Int J Radiat Oncol Biol Phys. 2006;66:S22
  5. Yovino SG, Garofalo MC, David V, et al. IMRT significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers: A multi-institutional experience (Abstr.). Int J Radiat Oncol Biol Phys. 2008;72:S254
  6. Herman JM, Swartz MJ, Hsu CC, et al. Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: Results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol. 2008;26:3503–3510
  7. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA. 2007;297:267–277
  8. Abrams RA, Lowy AM, O'Reilly EM, et al. Combined modality treatment of resectable and borderline resectable pancreas cancer: Expert consensus statement. Ann Surg Oncol. 2009;16:1751–1756
  9. Evans DB, Varadhachary GR, Crane CH, et al. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. J Clin Oncol. 2008;26:3496–3502
  10. Pawlik TM, Laheru D, Hruban RH, et al. Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer. Ann Surg Oncol. 2008;15:2081–2088
  11. Burris HA, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol. 1997;15:2403–2413
  12. Neoptolemos J, Büchler M, Stocken DD, et al. ESPAC-3(v2): A multicenter, international, open-label, randomized, controlled phase III trial of adjuvant 5-fluorouracil/folinic acid (5-FU/FA) versus gemcitabine (GEM) in patients with resected pancreatic ductal adenocarcinoma (Abstr.). J Clin Oncol. 2009;27:Late Breaking Abstract 4505
  13. Crane CH, Winter K, Regine WF, et al. Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411. J Clin Oncol. 2009;27:4096–4102
  14. Ford EC, Herman J, Yorke E, et al. 18F-FDG PET/CT for image-guided and intensity-modulated radiotherapy. J Nucl Med. 2009;50:1655–1665
  15. Iacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1806–1813

 Conflict of interest: none.

PII: S0360-3016(09)03577-9

doi: 10.1016/j.ijrobp.2009.11.036

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 3 , Pages 645-647 , 1 July 2010

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