International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 2 , Pages 566-574 , 1 June 2010

Depletion of Securin Induces Senescence After Irradiation and Enhances Radiosensitivity in Human Cancer Cells Regardless of Functional p53 Expression

  • Wen-Shu Chen

      Affiliations

    • Department of Life Science, Tzu Chi University, Hualien, Taiwan
    • ,
  • Yi-Chu Yu

      Affiliations

    • Department of Life Science, Tzu Chi University, Hualien, Taiwan
    • ,
  • Yi-Jang Lee, Ph.D.

      Affiliations

    • Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Ji-Hshiung Chen, Ph.D.

      Affiliations

    • Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan
    • ,
  • Hsue-Yin Hsu, Ph.D.

      Affiliations

    • Department of Life Science, Tzu Chi University, Hualien, Taiwan
    • ,
  • Shu-Jun Chiu, Ph.D.

      Affiliations

    • Department of Life Science, Tzu Chi University, Hualien, Taiwan
    • Institute of Radiation Sciences, Tzu Chi Technology College, Hualien, Taiwan
    • Corresponding Author InformationReprint requests to: Shu-Jun Chiu, Ph.D., Department of Life Science, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien 970, Taiwan. Tel: 886-3-8565301, ext. 2631; Fax: 886-3-8572526

Received 22 September 2009 ,Revised 16 October 2009 ,Accepted 10 December 2009.

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 Wen-Shu Chen and Yi-Chu Yu contributed equally to this work.

 This work was supported by a grant from the National Science Council, Taiwan (NSC 96-2321-B-320-001-MY3).

 Conflict of interest: none.

PII: S0360-3016(09)03678-5

doi: 10.1016/j.ijrobp.2009.12.013

International Journal of Radiation Oncology * Biology * Physics
Volume 77, Issue 2 , Pages 566-574 , 1 June 2010

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