Salvage Radiotherapy for Rising Prostate-Specific Antigen Levels After Radical Prostatectomy for Prostate Cancer: Dose–Response AnalysisPage 735
J. R. Bernard, Jr., S. J. Buskirk, M. G. Heckman, N. N. Diehl, S. J. Ko, O. K. Macdonald, S. E. Schild, and T. M. Pisansky
Radiation therapy to the prostate bed (salvage radiation therapy) is the only potentially curative treatment for patients who develop a rising PSA after radical prostatectomy. This study was performed to determine if we could identify a correlation with probability of cure according to the radiation dose delivered to the prostate bed. We were able to demonstate that patients had a higher probability of cure if the dose of salvage radiation therapy was >66 Gy. This information may be helpful for physicians to determine the prescibed dose of salvage prostate bed radiation therapy for their patients.
Influence of Technologic Advances on Outcomes in Patients with Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant ChemoradiotherapyPage 775
Z. X. Liao, R. R. Komaki, H. D. Thames, Jr., H. H. Liu, S. L. Tucker, R. Mohan, M. K. Martel, X. Wei, K. Yang, E. S. Kim, G. Blumenschein, W. Ki Hong, and J. D. Cox
“This article is on intensity modulated radiation (IMRT), an advanced technology to deliver radiation to lung cancer, compared with the standard three dimensional radiation. The idea of using this technique for lung cancer treatment is that IMRT can reduce the amount of the normal lung that gets irradiated to a harmful dose of radiation, thus reduce the toxicity. IMRT also has the unique advantage of delivering high dose to tumor while giving lower dose to surrounding tissue. In this study, all patients underwent 4-dimensional CT planning, an essential step to deal with the tumor movement due to breathing. We found that here was a significant reduction in toxicity, and a significant improvement in overall survival in patients who were treated by IMRT.”
Differential Radiosensitizing Effect of Valproic Acid in Differentiation Versus Self-Renewal Promoting Culture ConditionsPage 889
B. G. Debeb, W. Xu, H. Mok, L. Li, F. Robertson, N. T. Ueno, J. Reuben, A. Lucci, M. Cristofanilli, and W. A. Woodward
This article demonstrates that the radiosenstizing effct of a drug, in this case valproic acid, can be completely different in one culture system vs. another. Specifically, although valproic acid sensitized adherent breast cancer cells to radiation in standard clonogenic assays, it did not radiosensitize stem/progenitor cells as assessed by mammosphere formation assay. This suggests that the widely used standard clonogenic assays may not optimally select anti-cancer stem cell agents and that targeted therapies should be explicitly tested for their activity against the cancer stem cell population.
Implementation of a New Method for Dynamic Multileaf Collimator Tracking of Prostate Motion in Arc Radiotherapy Using a Single kV ImagerPage 914
P. R. Poulsen, B. Cho, A. Sawant, and P. J. Keall
One way to compensate for tumor motion during radiotherapy is dynamic multileaf collimator (DMLC) tracking, where the treatment beam is continuously aligned with the target by dynamic shifts of the MLC aperture. It requires a reliable real-time target position signal. The experiments in this paper use a single kV imager to generate the target position signal during arc radiotherapy. It is demonstrated that a tracking accuracy better than 1 millimeter can be obtained for most prostate trajectories. The study concludes that accurate image-based DMLC tracking of prostate during arc therapy can be performed with standard equipment for modern linear accelerators.
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