International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 2 , Pages 563-571 , 1 October 2010

Compartmental Targeting for mTHPC-Based Photodynamic Treatment In Vivo: Correlation of Efficiency, Pharmacokinetics, and Regional Distribution of Apoptosis

  • Julie Garrier, M.Sc.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Aude Bressenot, M.D., M.Sc.

      Affiliations

    • Service d'Anatomie et de Cytologie Pathologiques, CHU de Brabois, Vandœuvre-lès-Nancy, France
    • ,
  • Susanna Gräfe, Ph.D.

      Affiliations

    • Research and Development, Biolitec AG, Jena, Germany
    • ,
  • Sophie Marchal, Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Soumya Mitra, Ph.D.

      Affiliations

    • Department of Imaging Sciences, University of Rochester, Rochester, New York
    • ,
  • Thomas H. Foster, Ph.D.

      Affiliations

    • Department of Imaging Sciences, University of Rochester, Rochester, New York
    • ,
  • François Guillemin, M.D., Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Lina Bezdetnaya, M.D., Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • Corresponding Author InformationReprint requests to: Lina Bezdetnaya, M.D., Ph.D., CRAN-UMR 7039, Nancy-University, CNRS, Centre Alexis Vautrin, Avenue de Bourgogne, F-54511 Vandœuvre-lès-Nancy, France. Tel: 33 (0)3 83 59 83 06; Fax: 33 (0)3 83 59 83 78

Received 12 October 2009 ,Revised 12 April 2010 ,Accepted 14 April 2010.

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 This research was supported by the Alexis Vautrin Cancer Center and the French Ligue Nationale contre le Cancer and by U.S. National Institutes of Health grant CA68409 (to S.M. and T.H.F.).

 This work was presented at the 13th Congress of the European Society of Photobiology, Wroclaw, Poland, Sept 5-10, 2009.

 Conflict of interest: none.

PII: S0360-3016(10)00513-4

doi: 10.1016/j.ijrobp.2010.04.009

International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 2 , Pages 563-571 , 1 October 2010

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