International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 2 , Pages 563-571 , 1 October 2010

Compartmental Targeting for mTHPC-Based Photodynamic Treatment In Vivo: Correlation of Efficiency, Pharmacokinetics, and Regional Distribution of Apoptosis

  • Julie Garrier, M.Sc.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Aude Bressenot, M.D., M.Sc.

      Affiliations

    • Service d'Anatomie et de Cytologie Pathologiques, CHU de Brabois, Vandœuvre-lès-Nancy, France
    • ,
  • Susanna Gräfe, Ph.D.

      Affiliations

    • Research and Development, Biolitec AG, Jena, Germany
    • ,
  • Sophie Marchal, Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Soumya Mitra, Ph.D.

      Affiliations

    • Department of Imaging Sciences, University of Rochester, Rochester, New York
    • ,
  • Thomas H. Foster, Ph.D.

      Affiliations

    • Department of Imaging Sciences, University of Rochester, Rochester, New York
    • ,
  • François Guillemin, M.D., Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • ,
  • Lina Bezdetnaya, M.D., Ph.D.

      Affiliations

    • Centre de Recherche en Automatique de Nancy (CRAN-UMR 7039), Nancy-University, CNRS, Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France
    • Corresponding Author InformationReprint requests to: Lina Bezdetnaya, M.D., Ph.D., CRAN-UMR 7039, Nancy-University, CNRS, Centre Alexis Vautrin, Avenue de Bourgogne, F-54511 Vandœuvre-lès-Nancy, France. Tel: 33 (0)3 83 59 83 06; Fax: 33 (0)3 83 59 83 78

Received 12 October 2009 ,Revised 12 April 2010 ,Accepted 14 April 2010.

References 

  1. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889–905
  2. Triesscheijn M, Baas P, Schellens JH, et al. Photodynamic therapy in oncology. Oncologist. 2006;11:1034–1044
  3. Chen B, Pogue BW, Hoopes PJ, et al. Vascular and cellular targeting for photodynamic therapy. Crit Rev Eukaryot Gene Expr. 2006;16:279–305
  4. Cramers P, Ruevekamp M, Oppelaar H, et al. Foscan uptake and tissue distribution in relation to photodynamic efficacy. Br J Cancer. 2003;88:283–290
  5. Dolmans DE, Kadambi A, Hill JS, et al. Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy. Cancer Res. 2002;62:4289–4294
  6. Veenhuizen R, Oppelaar H, Ruevekamp M, et al. Does tumor uptake of Foscan determine PDT efficacy?. Int J Cancer. 1997;73:236–239
  7. Jones HJ, Vernon DI, Brown SB. Photodynamic therapy effect of m-THPC (Foscan) in vivo: correlation with pharmacokinetics. Br J Cancer. 2003;89:398–404
  8. Triesscheijn M, Ruevekamp M, Aalders M, et al. Outcome of mTHPC mediated photodynamic therapy is primarily determined by the vascular response. Photochem Photobiol. 2005;81:1161–1167
  9. Mitra S, Maugain E, Bolotine L, et al. Temporally and spatially heterogeneous distribution of mTHPC in a murine tumor observed by two-color confocal fluorescence imaging and spectroscopy in a whole-mount model. Photochem Photobiol. 2005;81:1123–1130
  10. Henderson BW, Gollnick SO, Snyder JW, et al. Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors. Cancer Res. 2004;64:2120–2126
  11. LaMuraglia GM, Schiereck J, Heckenkamp J, et al. Photodynamic therapy induces apoptosis in intimal hyperplastic arteries. Am J Pathol. 2000;157:867–875
  12. Wyllie AH. Apoptosis: an overview. Br Med Bull. 1997;53:451–465
  13. Oleinick NL, Morris RL, Belichenko I. The role of apoptosis in response to photodynamic therapy: What, where, why, and how. Photochem Photobiol Sci. 2002;1:1–21
  14. Engbrecht BW, Menon C, Kachur AV, et al. Photofrin-mediated photodynamic therapy induces vascular occlusion and apoptosis in a human sarcoma xenograft model. Cancer Res. 1999;59:4334–4342
  15. Lassalle HP, Dumas D, Grafe S, et al. Correlation between in vivo pharmacokinetics, intratumoral distribution and photodynamic efficiency of liposomal mTHPC. J Control Release. 2009;134:118–124
  16. Aalders MC, Triesscheijn M, Ruevekamp M, et al. Doppler optical coherence tomography to monitor the effect of photodynamic therapy on tissue morphology and perfusion. J Biomed Opt. 2006;11;044011
  17. Chen B, Pogue BW, Goodwin IA, et al. Blood flow dynamics after photodynamic therapy with verteporfin in the RIF-1 tumor. Radiat Res. 2003;160:452–459
  18. Chen B, Roskams T, de Witte PA. Antivascular tumor eradication by hypericin-mediated photodynamic therapy. Photochem Photobiol. 2002;76:509–513
  19. Karmakova T, Feofanov A, Pankratov A, et al. Tissue distribution and in vivo photosensitizing activity of 13,15-[ N-(3-hydroxypropyl)]cycloimide chlorin p6 and 13,15-(N-methoxy)cycloimide chlorin p6 methyl ester. J Photochem Photobiol B. 2006;82:28–36
  20. Li LB, Luo RC. Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model. Lasers Med Sci. 2009;24(4):597–603
  21. Olivo M, Chin W. Perylenequinones in photodynamic therapy: Cellular versus vascular response. J Environ Pathol Toxicol Oncol. 2006;25:223–237
  22. Zhou CN, Yang WZ, Ding ZX, et al. The biological effects of photodynamic therapy on normal skin in mice. I. A light microscopic study. Adv Exp Med Biol. 1985;193:105–109
  23. Ferrario A, Kessel D, Gomer CJ. Metabolic properties and photosensitizing responsiveness of mono-l-aspartyl chlorin e6 in a mouse tumor model. Cancer Res. 1992;52:2890–2893
  24. Gomer CJ, Ferrario A. Tissue distribution and photosensitizing properties of mono-l-aspartyl chlorin e6 in a mouse tumor model. Cancer Res. 1990;50:3985–3990
  25. Harada M, Woodhams J, MacRobert AJ, et al. The vascular response to photodynamic therapy with ATX-S10Na(II) in the normal rat colon. J Photochem Photobiol B. 2005;79:223–230
  26. Marchal S, Fadloun A, Maugain E, et al. Necrotic and apoptotic features of cell death in response to Foscan photosensitization of HT29 monolayer and multicell spheroids. Biochem Pharmacol. 2005;69:1167–1176
  27. Pervaiz S, Olivo M. Art and science of photodynamic therapy. Clin Exp Pharmacol Physiol. 2006;33:551–556
  28. Ball DJ, Vernon DI, Brown SB. The high photoactivity of m-THPC in photodynamic therapy. Unusually strong retention of m-THPC by RIF-1 cells in culture. Photochem Photobiol. 1999;69:360–363

 This research was supported by the Alexis Vautrin Cancer Center and the French Ligue Nationale contre le Cancer and by U.S. National Institutes of Health grant CA68409 (to S.M. and T.H.F.).

 This work was presented at the 13th Congress of the European Society of Photobiology, Wroclaw, Poland, Sept 5-10, 2009.

 Conflict of interest: none.

PII: S0360-3016(10)00513-4

doi: 10.1016/j.ijrobp.2010.04.009

International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 2 , Pages 563-571 , 1 October 2010

Article Tools

* Image Usage & Resolution