International Journal of Radiation Oncology * Biology * Physics
Volume 79, Issue 4 , Pages 1241-1247 , 15 March 2011

Data-Driven Approach to Generating Achievable Dose–Volume Histogram Objectives in Intensity-Modulated Radiotherapy Planning

Presented orally at the 51st Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Chicago, IL, November, 2009.

  • Binbin Wu, Ph.D.

      Affiliations

    • Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Francesco Ricchetti, M.D.

      Affiliations

    • Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Giuseppe Sanguineti, M.D.

      Affiliations

    • Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Michael Kazhdan, Ph.D.

      Affiliations

    • Department of Computer Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Patricio Simari, Ph.D.

      Affiliations

    • Department of Computer Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Robert Jacques, B.S.

      Affiliations

    • Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD
    • ,
  • Russell Taylor, Ph.D.

      Affiliations

    • Department of Computer Science, Johns Hopkins University, Baltimore, MD
    • ,
  • Todd McNutt, Ph.D.

      Affiliations

    • Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, Baltimore, MD
    • Corresponding Author InformationReprint requests to: Todd McNutt, Ph.D., Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University, 401 N. Broadway, Suite 1440, Baltimore, MD 21231-2410. Tel: (410) 614-4594; Fax: (410) 502-1419

Received 24 February 2010 ,Revised 14 May 2010 ,Accepted 14 May 2010.

References 

  1. Wu Q, Mohan R. Algorithms and functionality of an intensity modulated radiotherapy optimization system. Med Phys. 2000;27:701–711
  2. Wu Q, Chi Y, Chen PY, et al. Adaptive replanning strategies accounting for shrinkage in head and neck IMRT. Int J Radiat Oncol Biol Phys. 2009;75:924–932
  3. Chung HT, Lee B, Park E, et al. Can all centers plan intensity-modulated radiotherapy (IMRT) effectively? An external audit of dosimetric comparisons between three-dimensional conformal radiotherapy and IMRT for adjuvant chemoradiation for gastric cancer. Int J Radiat Oncol Biol Phys. 2008;71:1167–1174
  4. Williams MJ, Bailey M, Forstner D, et al. Multicentre quality assurance of intensity-modulated radiation therapy plans: A precursor to clinical trials. Australas Radiol. 2007;51:472–479
  5. Wu B, Ricchetti F, Sanguineti G, et al. Patient geometry-driven information retrieval for IMRT treatment plan quality control. Med Phys. 2009;36:5497–5505
  6. Kazhdan M, Simari P, McNutt T, et al. A shape relationship descriptor for radiation therapy planning. Lecture Notes Computer Sci. 2009;5762:100–108
  7. Eisbruch A, Harris J, Garden AS, et al. Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22). Int J Radiat Oncol Biol Phys. 2010;76:1333–1338
  8. Dabaja B, Salehpour MR, Rosen I, et al. Intensity-modulated radiation therapy (IMRT) of cancers of the head and neck: Comparison of split-field and whole-field techniques. Int J Radiat Oncol Biol Phys. 2005;63:1000–1005
  9. Wu Q, Mohan R, Niemierko A, et al. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. Int J Radiat Oncol Biol Phys. 2002;52:224–235
  10. Thieke C, Bortfeld T, Niemierko A, et al. From physical dose constraints to equivalent uniform dose constraints in inverse radiotherapy planning. Med Phys. 2003;30:2332–2339

 Supported by Philips Radiation Oncology Systems and the generosity of Paul Maritz.

 Conflict of interest: none.

PII: S0360-3016(10)00749-2

doi: 10.1016/j.ijrobp.2010.05.026

International Journal of Radiation Oncology * Biology * Physics
Volume 79, Issue 4 , Pages 1241-1247 , 15 March 2011

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