International Journal of Radiation Oncology * Biology * Physics
Volume 81, Issue 2 , Pages 483-489 , 1 October 2011

Single-Dose Versus Fractionated Stereotactic Radiotherapy for Brain Metastases

  • Yeon-Joo Kim, M.D.

      Affiliations

    • Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Kwan Ho Cho, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • Corresponding Author InformationReprint requests to: Kwan Ho Cho, M.D., Proton Therapy Center, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang, Gyeonggi, 410-769, Republic of Korea. Tel: 82-31-920-1720; Fax: 82-31-920-0149
    • ,
  • Joo-Young Kim, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Young Kyung Lim, Ph.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Hye Sook Min, M.D.

      Affiliations

    • Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Sang Hyun Lee, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Ho Jin Kim, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Ho Shin Gwak, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Heon Yoo, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • ,
  • Seung Hoon Lee, M.D.

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea

Received 11 January 2010 ,Revised 25 May 2010 ,Accepted 25 May 2010.

References 

  1. Cairncross JG, Kim JH, Posner JB. Radiation therapy for brain metastases. Ann Neurol. 1980;7:529–541
  2. Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37:745–751
  3. Cho KH, Hall WA, Gerbi BJ, et al. Patient selection criteria for the treatment of brain metastases with stereotactic radiosurgery. J Neurooncol. 1998;40:73–86
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  14. Manning MA, Cardinale RM, Benedict SH, et al. Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases. Int J Radiat Oncol Biol Phys. 2000;47:603–608
  15. Aoyama H, Shirato H, Onimaru R, et al. Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull. Int J Radiat Oncol Biol Phys. 2003;56:793–800
  16. Ernst-Stecken A, Ganslandt O, Lambrecht U, et al. Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: Results and toxicity. Radiother Oncol. 2006;81:18–24
  17. Fahrig A, Ganslandt O, Lambrecht U, et al. Hypofractionated stereotactic radiotherapy for brain metastases-results from three different dose concepts. Strahlenther Onkol. 2007;183:625–630
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  19. Kwon AK, Dibiase SJ, Wang B, et al. Hypofractionated stereotactic radiotherapy for the treatment of brain metastases. Cancer. 2009;115:890–898

 Supported in part by NCC Grant 0210140 from the National Cancer Center, Korea.

 Conflict of interest: none.

PII: S0360-3016(10)00756-X

doi: 10.1016/j.ijrobp.2010.05.033

International Journal of Radiation Oncology * Biology * Physics
Volume 81, Issue 2 , Pages 483-489 , 1 October 2011

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