International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 4 , Pages 1193-1200 , 15 November 2010

Effect of Hyperoxygenation on Tissue pO2 and Its Effect on Radiotherapeutic Efficacy of Orthotopic F98 Gliomas

  • Nadeem Khan, Ph.D.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
    • Corresponding Author InformationReprint requests to: Nadeem Khan, Ph.D., EPR Center for Viable Systems, 703 Vail, Dartmouth Medical School, Hanover, NH 03755. Tel: (603) 653 3591; Fax: (603) 650 1717
  • ,
  • Sriram Mupparaju, M.S.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • Shahryar K. Hekmatyar, Ph.D.

      Affiliations

    • Biomedical NMR Research Center, Dartmouth Medical School, Hanover, New Hampshire
  • ,
  • Huagang Hou, M.D.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • Jean P. Lariviere, B.A.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • Eugene Demidenko, Ph.D.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • David J. Gladstone, Sc.D.

      Affiliations

    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
  • ,
  • Risto A. Kauppinen, M.D, Ph.D.

      Affiliations

    • Biomedical NMR Research Center, Dartmouth Medical School, Hanover, New Hampshire
  • ,
  • Harold M. Swartz, M.D., Ph.D.

      Affiliations

    • EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire
    • Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

Received 17 November 2009 ,Revised 20 April 2010 ,Accepted 25 May 2010.

References 

  1. Buckner JC, Brown PD, O'Neill BP, et al. Central nervous system tumors. Mayo Clin Proc. 2007;82:1271–1286
  2. Kanu OO, Hughes B, Di C, et al. Glioblastoma multiforme oncogenomics and signaling pathways. Clin Med Oncol. 2009;3:39–52
  3. Clarke J, Butowski N, Chang S. Recent advances in therapy for glioblastoma. Arch Neurol. 2010;67:279–283
  4. Quick A, Patel D, Hadziahmetovic M, et al. Current therapeutic paradigms in glioblastoma. Rev Recent Clin Trials. 2009;5:14–27
  5. Combs SE. Radiation therapy. Recent Results Cancer Res. 2009;171:125–140
  6. Romanelli P, Conti A, Pontoriero A, et al. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of recurrent glioblastoma multiforme. Neurosurg Focus. 2009;27:E1–E11
  7. Nieder C, Astner ST, Mehta MP, et al. Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma. Am J Clin Oncol. 2008;31:300–305
  8. Khuntia D, Tome WA, Mehta MP. Radiation techniques in neuro-oncology. Neurotherapeutics. 2009;6:487–499
  9. Quick A, Patel D, Hadziahmetovic M, et al. Current therapeutic paradigms in glioblastoma. Rev Recent Clin Trials. 2009;5:14–27
  10. Preusser M, Haberler C, Hainfellner JA. Malignant glioma: Neuropathology and neurobiology. Wien Med Wochenschr. 2006;156:332–337
  11. Jensen RL. Brain tumor hypoxia: Tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol. 2009;92:317–335
  12. Oliver L, Olivier C, Marhuenda FB, et al. Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy. Curr Mol Pharmacol. 2009;2:263–284
  13. Tatum JL, Kelloff GJ, Gillies RJ, et al. Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006;82:699–757
  14. Vaupel P. Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist. 2008;13(Suppl 3):21–26
  15. Khan N, Li H, Hou H, et al. Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation. Int J Radiat Oncol Biol Phys. 2009;73:878–885
  16. Khan N, Williams BB, Hou H, et al. Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: Current status and future potential for experimental and clinical studies. Antioxid Redox Signal. 2007;9:1169–1182
  17. Liu KJ, Gast P, Moussavi M, et al. Lithium phthalocyanine: A probe for electron paramagnetic resonance oximetry in viable biological systems. Proc Natl Acad Sci U S A. 1993;90:5438–5442
  18. Swartz HM, Clarkson RB. The measurement of oxygen in vivo using EPR techniques. Phys Med Biol. 1998;43:1957–1975
  19. Williams BB, Hou H, Grinberg OY, et al. High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat. Antioxid Redox Signal. 2007;9:1691–1698
  20. Barth RF, Kaur B. Rat brain tumor models in experimental neuro-oncology: The C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas. J Neurooncol. 2009;94:299–312
  21. Chenevert TL, McKeever PE, Ross BD. Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res. 1997;3:1457–1466
  22. Kauppinen RA. Monitoring cytotoxic tumour treatment response by diffusion magnetic resonance imaging and proton spectroscopy. NMR Biomed. 2002;15:6–17
  23. Mori S, van Zijl PC. Diffusion weighting by the trace of the diffusion tensor within a single scan. Magn Reson Med. 1995;33:41–52
  24. Denekamp J, Waites T, Fowler JF. Predicting realistic RBE values for clinically relevant radiotherapy schedules. Int J Radiat Biol. 1997;71:681–694
  25. Dale RG, Jones B, Sinclair JA. Dose equivalents of tumour repopulation during radiotherapy: the potential for confusion. Br J Radiol. 2000;73:892–894
  26. Draper N, Smith H. Applied regression analysis. 3rd edition. New York: Wiley; 1998;
  27. Bussink J, Kaanders JH, Strik AM, et al. Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescence based fiber-optic probes. Radiother Oncol. 2000;57:21–30
  28. Gu Y, Bourke VA, Kim JG, et al. Dynamic response of breast tumor oxygenation to hyperoxic respiratory challenge monitored with three oxygen-sensitive parameters. Appl Opt. 2003;42:2960–2967
  29. Thews O, Kelleher DK, Vaupel P. Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia. Radiother Oncol. 2002;62:77–85
  30. Bache M, Kappler M, Said HM, et al. Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies. Curr Med Chem. 2008;15:322–338
  31. Hou H, Lariviere JP, Demidenko E, et al. Repeated tumor pO2 measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapy. Radiother Oncol. 2009;91(1):126–131
  32. Crokart N, Jordan BF, Baudelet C, et al. Early reoxygenation in tumors after irradiation: Determining factors and consequences for radiotherapy regimens using daily multiple fractions. Int J Radiat Oncol Biol Phys. 2005;63:901–910
  33. Barth RF, Yang W, Rotaru JH, et al. Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine. Int J Radiat Oncol Biol Phys. 2000;47:209–218
  34. Biston MC, Joubert A, Adam JF, et al. Cure of Fisher rats bearing radioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays. Cancer Res. 2004;64:2317–2323
  35. Rousseau J, Barth RF, Moeschberger ML, et al. Efficacy of intracerebral delivery of Carboplatin in combination with photon irradiation for treatment of F98 glioma-bearing rats. Int J Radiat Oncol Biol Phys. 2009;73:530–536
  36. Valonen PK, Lehtimaki KK, Vaisanen TH, et al. Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density. J Magn Reson Imaging. 2004;19:389–396

 This work was supported by NIH Grants CA120919 and CA118069 to N.K. and PO1EB2180 to H.M.S.

 Conflict of interest: none.

PII: S0360-3016(10)00788-1

doi: 10.1016/j.ijrobp.2010.05.045

International Journal of Radiation Oncology * Biology * Physics
Volume 78, Issue 4 , Pages 1193-1200 , 15 November 2010