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International Journal of Radiation Oncology * Biology * Physics
Volume 49, Issue 2, Pages 299-616 (01 February 2001)
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ICTR 2000


ICTR 2000: individualizing cancer treatment
On behalf of the ICTR 2000 Organising Committee, J. Bernier, S.M. Bentzen, W.G. McKenna, T.J. McMillan, M.J. Zelefsky
page 299
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International conference on translational research and preclinical strategies in radio-oncology (ICTR)—conference summary
C.Norman Coleman
pages 301-309
Full Text | Full-Text PDF (349 KB)


From translational research to improved local control and survival: the Gilbert Fletcher award lecture, Lugano, March 2000
Harry Bartelink
pages 311-318
Abstract | Full Text | Full-Text PDF (348 KB)


Therapeutic targets in radiotherapy
J.Martin Brown
pages 319-326
Abstract | Full Text | Full-Text PDF (350 KB)


Individualizing cancer treatment: biological optimization models in treatment planning and delivery
Anders Brahme
pages 327-337
Abstract | Full Text | Full-Text PDF (3779 KB)


Collaborative clinical trials: quality or quantity?
Ian F Tannock
pages 339-343
Abstract | Full Text | Full-Text PDF (58 KB)


The translational research chain: is it delivering the goods?
Michael Baumann, Søren M Bentzen, Wolfgang Doerr, Michael C Joiner, Michele Saunders, Ian F Tannock, Howard D Thames
pages 345-351
Abstract | Full Text | Full-Text PDF (83 KB)


Normal tissue radiobiology: from the laboratory to the clinic
R.P Hill, H.-P Rodemann, J.H Hendry, S.A Roberts, M.S Anscher
pages 353-365
Abstract | Full Text | Full-Text PDF (174 KB)


Genetic manipulation of radiosensitivity
Adrian C Begg, Conchita Vens
pages 367-371
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The use of DNA double-strand break quantification in radiotherapy
Trevor J McMillan, Simon Tobi, Santiago Mateos, Catherine Lemon
pages 373-377
Abstract | Full Text | Full-Text PDF (122 KB)


Low-dose hypersensitivity: current status and possible mechanisms
Michael C Joiner, Brian Marples, Philippe Lambin, Susan C Short, Ingela Turesson
pages 379-389
Abstract | Full Text | Full-Text PDF (198 KB)


Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy
Olga A Sedelnikova, Andrew N Luu, Valeri N Karamychev, Igor G Panyutin, Ronald D Neumann
pages 391-396
Abstract | Full Text | Full-Text PDF (239 KB)


Effect of protein kinase C inhibitor (PKCI) on radiation sensitivity and c-fos transcription
Eun Kyung Choi, Yun-Hee Rhee, HeonJoo Park, Seung Do Ahn, Kyung Hwan Shin, Kun-Koo Park
pages 397-405
Abstract | Full Text | Full-Text PDF (457 KB)


In vivo evaluation of a novel antitumor prodrug, 1-(2′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
Yuta Shibamoto, Ling Zhou, Hiroshi Hatta, Mayuko Mori, Sei-Ichi Nishimoto
pages 407-413
Abstract | Full Text | Full-Text PDF (185 KB)


Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis
Gerald A Ruiter, Marcel Verheij, Shuraila F Zerp, Wim J van Blitterswijk
pages 415-419
Abstract | Full Text | Full-Text PDF (181 KB)


Wortmannin selectively enhances radiation-induced apoptosis in proliferative but not quiescent cells
Yu-Quan Shi, Hans Blattmann, Nigel E.A Crompton
pages 421-425
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Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation
Paul M Harari, Shyh-Min Huang
pages 427-433
Abstract | Full Text | Full-Text PDF (869 KB)


bcl-2 expression in head and neck cancer: an enigmatic prognostic marker
George D Wilson, M.I Saunders, S Dische, P.I Richman, F.M Daley, Søren M Bentzen
pages 435-441
Abstract | Full Text | Full-Text PDF (104 KB)


In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
Willy Landuyt, Bisan Ahmed, Sandra Nuyts, Jan Theys, Michel Op de Beeck, Alex Rijnders, Jozef Anné, Allan van Oosterom, Walter Van den Bogaert, Philippe Lambin
pages 443-450
Abstract | Full Text | Full-Text PDF (295 KB)


Liver irradiation: a potential preparative regimen for hepatocyte transplantation
Chandan Guha, Bhupesh Parashar, Niloy J Deb, Anand Sharma, Giridhar R Gorla, Alan Alfieri, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury, Bhadrasain Vikram
pages 451-457
Abstract | Full Text | Full-Text PDF (71 KB)


Evaluation of glass microspheres for intra-arterial radiotherapy in animal kidneys
Norio Araki, Yasushi Nagata, Kazuhisa Fujiwara, Tetsuya Aoki, Michihide Mitsumori, Hiroyuki Kimura, Satoshi Itasaka, Hidekazu Saitou, Masahiro Hiraoka, Masakazu Kawashita, Tadashi Kokubo
pages 459-463
Abstract | Full Text | Full-Text PDF (298 KB)


Intensity modulated radiation therapy (IMRT) following prostatectomy: more favorable acute genitourinary toxicity profile compared to primary IMRT for prostate cancer
Bin S Teh, Wei-Yuan Mai, Mark E Augspurger, Barry M Uhl, John McGary, Lei Dong, Walter H Grant, E.Brian Butler, Hsin H Lu, Shiao Y Woo, L.Steven Carpenter, J.Kam Chiu
pages 465-472
Abstract | Full Text | Full-Text PDF (637 KB)


Correlations between dose–surface histograms and the incidence of long-term rectal bleeding following conformal or conventional radiotherapy treatment of prostate cancer
John D. Fenwick, Vincent S. Khoo, Alan E. Nahum, Beatriz Sanchez-Nieto, David P. Dearnaley
pages 473-480
Abstract | Full Text | Full-Text PDF (268 KB)


Modeling tumor and treated lung volume influences in the irradiation of non–small-cell lung cancer patients
Raymond P Abratt
pages 481-485
Abstract | Full Text | Full-Text PDF (74 KB)


Individualization of dose prescription based on normal-tissue dose–volume and radiosensitivity data
Beatriz Sanchez-Nieto, Alan E Nahum, David P Dearnaley
pages 487-499
Abstract | Full Text | Full-Text PDF (1699 KB)


Predictive assays: will they ever have a role in the clinic?
Lester Peters, Michael McKay
pages 501-504
Full Text | Full-Text PDF (140 KB)


Is there a future for cell kinetic measurements using IdUrd or BdUrd?
Karin Haustermans, Jack F Fowler
pages 505-511
Abstract | Full Text | Full-Text PDF (522 KB)


Prognostic factor studies in oncology: osteosarcoma as a clinical example
Søren M Bentzen
pages 513-518
Abstract | Full Text | Full-Text PDF (338 KB)


Interaction between potential doubling time and TP53 mutation: predicting radiotherapy outcome in squamous cell carcinoma of the head and neck
Jan Alsner, Morten Høyer, Susanne Berg Sørensen, Jens Overgaard
pages 519-525
Abstract | Full Text | Full-Text PDF (233 KB)


Impact of neoadjuvant chemotherapy on Ki-67 and PCNA labeling indices for esophageal squamous cell carcinomas
Naotoshi Horii, Yasumasa Nishimura, Yoshishige Okuno, Shuichi Kanamori, Masahiro Hiraoka, Yutaka Shimada, Masayuki Imamura
pages 527-532
Abstract | Full Text | Full-Text PDF (103 KB)


Radiation-induced chromatid breaks as a predictor of breast cancer risk
Thomas A Buchholz, Xifeng Wu
pages 533-537
Abstract | Full Text | Full-Text PDF (329 KB)


Breast cancer after mantle irradiation for Hodgkin’s disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2
David K Gaffney, John Hemmersmeier, Joseph Holden, Jay Marshall, Lynn M Smith, Vilija Avizonis, Thao Tran, Susan L Neuhausen
pages 539-546
Abstract | Full Text | Full-Text PDF (757 KB)


Sources of variation in patient response to radiation treatment
Nigel E.A Crompton, Yu-Quan Shi, Gillian C Emery, Lothar Wisser, Hans Blattmann, Andreas Maier, Ling Li, Detlef Schindler, Hülya Ozsahin, Mahmut Ozsahin
pages 547-554
Abstract | Full Text | Full-Text PDF (393 KB)


High levels of delayed radiation-induced apoptosis observed in lymphoblastoid cell lines from ataxia-telangiectasia patients
Yu-Quan Shi, Ling Li, Oezden Sanal, Ilhan Tezcan, Gillian C Emery, Hans Blattmann, Nigel E.A Crompton
pages 555-559
Abstract | Full Text | Full-Text PDF (183 KB)


Key targets for the execution of radiation-induced tumor cell apoptosis: the role of p53 and caspases
Martin Pruschy, Sonia Rocha, Kathrin Zaugg, Angela Tenzer, Cyrill Hess, David E Fisher, Christoph Glanzmann, Stephan Bodis
pages 561-567
Abstract | Full Text | Full-Text PDF (294 KB)


Semiquantitative immunohistochemical analysis for hypoxia in human tumors
James A Raleigh, Shu-Chuan Chou, Erika L Bono, Donald E Thrall, Mahesh A Varia
pages 569-574
Abstract | Full Text | Full-Text PDF (540 KB)


A pilot study comparing intratumoral oxygenation using the comet assay following 2.5% and 5% carbogen and 100% oxygen
Sarah E Partridge, Christina Aquino-Parsons, Chenmei Luo, Alexander Green, Peggy L Olive
pages 575-580
Abstract | Full Text | Full-Text PDF (456 KB)


Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
Marianne Nordsmark, Juliette Loncaster, Shu-Chuan Chou, Hanne Havsteen, Jacob C Lindegaard, Susan E Davidson, Mahesh Varia, Catharine West, Robin Hunter, Jens Overgaard, James A Raleigh
pages 581-586
Abstract | Full Text | Full-Text PDF (169 KB)


Hypoxia in human intraperitoneal and extremity sarcomas
Sydney M Evans, Stephen M Hahn, Deirdre P Magarelli, Paul J Zhang, W.Timothy Jenkins, Douglas L Fraker, R.Alex Hsi, W.Gillies McKenna, Cameron J Koch
pages 587-596
Abstract | Full Text | Full-Text PDF (711 KB)


Long-term normal tissue effects of intraoperative electron radiation therapy (IOERT): late sequelae, tumor recurrence, and second malignancies
Ignacio Azinovic, Felipe A Calvo, Fernando Puebla, Javier Aristu, Rafael Martı́nez-Monge
pages 597-604
Abstract | Full Text | Full-Text PDF (80 KB)


The use of a permanent magnetic resonance imaging system for radiotherapy treatment planning of bone metastases
Takashi Mizowaki, Norio Araki, Yasushi Nagata, Yoshiharu Negoro, Tetsuya Aoki, Masahiro Hiraoka
pages 605-611
Abstract | Full Text | Full-Text PDF (184 KB)

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