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Purpose/Objective: Radiation dermatitis is common among children and adults treated with radiation therapy
(RT). Treatment interruptions occur in severe cases impacting a planned course of
continuous RT. Radiation dermatitis is known to be exacerbated by pre-existing conditions,
the administration of chemotherapy or therapeutic intent. No specific agent has been
identified as superior in the prevention of this treatment-related effect. A phase
III trial was conducted to compare a novel anionic phospholipid-based (APP) cream
and an aloe vera-based gel in the prevention and treatment of radiation dermatitis
using qualitative and quantitative measures in children treated with radiation therapy.
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