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A phase III trial comparing an anionic phospholipid-based (APP) cream and aloe vera-based gel in the prevention and treatment of radiation dermatitis

      Purpose/Objective: Radiation dermatitis is common among children and adults treated with radiation therapy (RT). Treatment interruptions occur in severe cases impacting a planned course of continuous RT. Radiation dermatitis is known to be exacerbated by pre-existing conditions, the administration of chemotherapy or therapeutic intent. No specific agent has been identified as superior in the prevention of this treatment-related effect. A phase III trial was conducted to compare a novel anionic phospholipid-based (APP) cream and an aloe vera-based gel in the prevention and treatment of radiation dermatitis using qualitative and quantitative measures in children treated with radiation therapy.
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