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In Regard to de Lima et al

      To the Editor: The Brazilian investigators should be applauded for pursuing a randomized, double-blind controlled trial, seeking to determine whether low-level laser (LLL) therapy can effectively reduce oral mucositis in head-and-neck cancer patients undergoing concurrent chemoradiation therapy (
      • de Lima A.G.
      • Villar R.C.
      • de Castro G.
      • et al.
      Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study.
      ). This is certainly an important topic that affects many patients. To date, there have been limited gains in effective preventive treatments for oral mucositis (
      • Rubenstein E.B.
      • Peterson D.E.
      • Schubert M.
      • et al.
      Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis.
      ,
      • Raber-Durlacher J.E.
      • Elad S.
      • Barasch A.
      Oral mucositis.
      ). However, several limitations in the study methodology severely hinder the ability to assess whether the intervention is effective or not.
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      References

        • de Lima A.G.
        • Villar R.C.
        • de Castro G.
        • et al.
        Oral mucositis prevention by low-level laser therapy in head-and-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study.
        Int J Radiat Oncol Biol Phys. 2012; 82: 270-275
        • Rubenstein E.B.
        • Peterson D.E.
        • Schubert M.
        • et al.
        Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis.
        Cancer. 2004; 100: 2026-2046
        • Raber-Durlacher J.E.
        • Elad S.
        • Barasch A.
        Oral mucositis.
        Oral Oncol. 2010; 46: 452-456

      Linked Article

      • Oral Mucositis Prevention By Low-Level Laser Therapy in Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Phase III Randomized Study
        International Journal of Radiation Oncology • Biology • PhysicsVol. 82Issue 1
        • Preview
          Oral mucositis is a major complication of concurrent chemoradiotherapy (CRT) in head-and-neck cancer patients. Low-level laser (LLL) therapy is a promising preventive therapy. We aimed to evaluate the efficacy of LLL therapy to decrease severe oral mucositis and its effect on RT interruptions.
        • Full-Text
        • PDF
      • In Reply to Olson
        International Journal of Radiation Oncology • Biology • PhysicsVol. 85Issue 4
        • Preview
          To the Editor: We thank Dr Olson for the interest in our publication (1, 2). As mentioned, the effect of measures to prevent chemoradiation-induced oral mucositis (OM) is limited. When designing the study, we estimated a 30% decrease in the incidence of grade 3 to 4 OM (80% in the control arm vs 50% in the experimental arm), judged as clinically meaningful, considering that the real impact of low-level laser (LLL) therapy in this scenario was unknown.
        • Full-Text
        • PDF

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