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Patient-Level DNA Damage and Repair Pathway Profiles Are Prognostic After Prostatectomy for High-Risk Prostate Cancer

      A substantial number of patients diagnosed with high-risk prostate cancer are at risk for metastatic progression after radical prostatectomy. However, the risk is not uniform, even among patients with clinicopathological treatment indications for adjuvant radiotherapy. Better biomarkers are needed to identify patients at highest risk so that therapy can be intensified, while sparing lower-risk patients from the side-effects of unnecessary therapy. We hypothesized that DNA damage and repair pathways (damage checkpoint, DNA repair, DSB repair, HRR, NHEJ, BER, NER, and MMR) could serve as prognostic biomarkers in high-risk prostate cancer.
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