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Safety Results of a Multi-Institutional Phase 1 Clinical Trial of Afatinib in Combination with Docetaxel and Postoperative Radiation Therapy for High-Risk Squamous Cell Carcinoma of the Head and Neck

      Afatinib is an oral, irreversible EGFR/ErbB family receptor inhibitor with clinical activity in recurrent/metastatic SCCHN. Previously, EGFR-inhibition with cetuximab in combination with docetaxel and PORT was shown in RTOG 0234 to be well tolerated with higher rates of disease-free survival compared to historical results with cisplatin and PORT. We therefore aimed to assess the tolerability of afatinib in combination with docetaxel and PORT in a cohort of patients with high-risk pathologic features after definitive surgery.
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